Ligand N-acetyl-L-aspartic acid

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Basic Ligand Information

Molecular Structure
Picture of N-acetyl-L-aspartic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H9NO5
N-acetyl-L-aspartic acid
OTCCIMWXFLJLIA-BYPYZUCNSA-N
Synonyms:
acetyl-Asp, acetyl-L-aspartate, N-acetyl-alpha-L-aspartate, N-acetyl-Asp, N-acetyl-aspartate, N-acetyl-L-Asp, N-acetyl-L-aspartate, N-acetylaspartate, N-acetylaspartic acid, N-alpha-acetyl-L-aspartate, Nalpha-acetyl-L-Asp
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl-L-aspartate + O2 = ? + H2O2
show the reaction diagram
-
ATP + N-acetyl-L-aspartate = ADP + N-acetyl-4-phospho-L-aspartate
show the reaction diagram
-
N-acetyl-L-aspartate = acetate + L-aspartate
show the reaction diagram
-
N-acetyl-L-aspartate + H2O = acetate + L-aspartate
show the reaction diagram
-
Nalpha-acetyl-L-Asp + H2O = methanol + CO2 + L-Asp
show the reaction diagram
-
N-acetyl-L-aspartate + H2O = acetate + L-aspartate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + L-aspartate = CoA + N-acetyl-L-aspartate
show the reaction diagram
-
N-acetyl-L-asparagine + H2O = N-acetyl-L-aspartate + NH3
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
N-acetylaspartate acts as activator at low concentrations, substrate at moderate concentrations, and inhibitor at high concentrations
-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2 mM, 25% inhibition
-
0.1 mM, 38% inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (12 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.1
-
E167R mutant protein, pH not specified in the publication, temperature not specified in the publication

KM Value (15 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
48
-
pH 8.0, 25C, aspartokinase III
5
-
pH 7.0, 30C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.56
-
-
9889

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.85
-
IC50: 0.85 mM

References & Links

Links to other databases for N-acetyl-L-aspartic acid

ChEBI
PubChem
ChEBI
PubChem