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BRENDA support

Ligand O-phospho-L-serine

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Basic Ligand Information

Molecular Structure
Picture of O-phospho-L-serine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H8NO6P
O-phospho-L-serine
BZQFBWGGLXLEPQ-REOHCLBHSA-N
Synonyms:
3-O-phospho-L-serine, 3-phospho-L-serine, 3-phosphoserine, L-2-amino-3-phosphonopropionic acid, L-3-phosphoserine, L-O-phospho-serine, L-O-Phosphoserine, L-phosphoserine, L-serine-O-phosphate, L-serine O-3-phosphate, L3-phosphoserine, O-phospho-(S)-Ser, O-phospho-L-Ser, O-phospho-serine, o-phosphoryl-L-serine, O-phosphoserine, O-phospohomoserine, O3-phospho-L-serine, phospho-L-Ser, phospho-L-serine, phosphorylserine, phosphoserine
Pathway Source
Pathways
BRENDA
coenzyme M biosynthesis, cysteine metabolism, dapdiamides biosynthesis, serine metabolism
KEGG
Aminoacyl-tRNA biosynthesis, Biosynthesis of amino acids, Biosynthesis of secondary metabolites, Biosynthesis of various antibiotics, Biosynthesis of various other secondary metabolites more
MetaCyc
coenzyme M biosynthesis II, dapdiamides biosynthesis, L-cysteine biosynthesis II (tRNA-dependent), L-cysteine biosynthesis IX (Trichomonas vaginalis), L-cysteine biosynthesis V (mycobacteria) more


Show all pahtways known for Show all BRENDA pathways known for O-phospho-L-serine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (34 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-phospho-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + phosphate
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O-phospho-L-serine + L-glutamate = N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate
show the reaction diagram
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3-phospho-L-serine + thiosulfate = S-sulfo-L-cysteine + phosphate
show the reaction diagram
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L-serine O-3-phosphate = ethanolamine-phosphate + CO2
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (7 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + L-serine = ADP + O-phospho-L-serine
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ADP + L-serine = AMP + O-phospho-L-serine
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diphosphate + L-serine = phosphate + O-phospho-L-serine
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Substrate in Enzyme-catalyzed Reactions (108 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-phospho-(S)-Ser + pyruvate + NADH + H+ = N-[1-(R)-(carboxy)ethyl]-(S)-O-phospho-Ser + NAD+
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O-phospho-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + phosphate
show the reaction diagram
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O-phospho-L-serine + L-glutamate = N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate
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O-phosphoserine + H2S = L-Cys + phosphate
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O-phospho-L-serine + L-cysteine = ?
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L-phosphoserine + sulfite = L-cysteate + phosphate
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L-phosphoserine + H2O = L-serine + phosphate
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O-phospho-L-serine + H2O = Ser + phosphate
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phospho-L-serine + H2O = L-serine + phosphate
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O-phospho-L-serine + H2O = L-serine + phosphate
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L-serine O-3-phosphate = ethanolamine-phosphate + CO2
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O-phospho-L-serine + indole = L-tryptophan + phosphate
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Product in Enzyme-catalyzed Reactions (14 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + L-serine = ADP + O-phospho-L-serine
show the reaction diagram
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ADP + L-serine = AMP + O-phospho-L-serine
show the reaction diagram
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diphosphate + L-serine = phosphate + O-phospho-L-serine
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2 mM, 1.5fold activation
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Inhibitor in Enzyme-catalyzed Reactions (19 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition
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competitive to L-serine
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inhibition of brain KAT II
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PdeA shows 59% relative activity and PdeB shows 73% relative activity in the hydrolysis of 3',5'-cAMP in the presence of 0.05 mM phosphoserine
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PdeA and PdeB show 59% and 73% residual activity, respectively, for 3',5'-cAMP hydrolysis at 5 mM phosphoserine
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competitive
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3D Structure of Enzyme-Ligand-Complex (PDB) (25767 results)

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EC NUMBER
ENZYME 3D STRUCTURE