Ligand pantetheine

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Basic Ligand Information

Molecular Structure
Picture of pantetheine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C11H22N2O4S
pantetheine
ZNXZGRMVNNHPCA-VIFPVBQESA-N
Synonyms:
(R)-pantetheine, pantotheine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + pantetheine = ADP + pantetheine 4'-phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-[(R)-pantothenoyl]-L-cysteine = pantetheine + CO2
show the reaction diagram
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D-pantothenoylcysteine = pantotheine + CO2
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pantetheine + O2 = pantothenate + cysteamine
show the reaction diagram
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acetyl-CoA + pantetheine = CoA + acetyl-S-pantetheine
show the reaction diagram
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malonyl-CoA + pantetheine = malonyl-pantetheine + CoA
show the reaction diagram
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pantetheine + ATP = D-4'-phosphopantetheine + ADP
show the reaction diagram
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ATP + pantetheine = ADP + pantetheine 4'-phosphate
show the reaction diagram
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ATP + fatty acid + pantetheine = AMP + diphosphate + acyl-pantetheine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pantetheine-glutathione + GSH = pantetheine + GSSG
show the reaction diagram
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malonyl-pantetheine + acyl-carrier protein = pantetheine + malonyl-[acyl-carrier protein]
show the reaction diagram
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acetylpantetheine + acetoacetyl-CoA + H2O = 3-hydroxy-3-methylglutaryl-CoA + pantetheine
show the reaction diagram
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formylpantetheine + H2O = pantetheine + formate
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oleoyl pantetheine + H2O = oleate + pantetheine
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oleoyl pantetheine + H2O = oleate + pantetheine
show the reaction diagram
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N-[(R)-pantothenoyl]-L-cysteine = pantetheine + CO2
show the reaction diagram
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D-pantothenoylcysteine = pantotheine + CO2
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulating
-
mevaldehyde reduction
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak, competitive
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potent inhibitor

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
11
-
-
0.00134
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Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.2
-
-

References & Links

Links to other databases for pantetheine

ChEBI
PubChem
ChEBI
PubChem