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Ligand (S)-2-hydroxyacid

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.99

L-2-hydroxy fatty acid + NAD+ = 2-keto fatty acid + NADH + H+

287559

-

1.1.3.15

an (S)-2-hydroxy carboxylate + O2 = a 2-oxo carboxylate + H2O2

745481, 745609, 745815, 745737

-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

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Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.337

a 2-oxocarboxylate + NADH + H+ = (2S)-2-hydroxycarboxylate + NAD+

0

-

3.8.1.10

(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide

0

-

3.8.1.11

(S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide

0

-

3.8.1.2

DL-2-haloalkanoic acid + H2O = L-2-hydroxyalkanoic acid + D-2-hydroxyalkanoic acid + halide

0

-

3.8.1.9

(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide

0

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.99

L-2-hydroxy fatty acid + NAD+ = 2-keto fatty acid + NADH + H+

287559

-

1.1.3.15

an (S)-2-hydroxy carboxylate + O2 = a 2-oxo carboxylate + H2O2

745481, 745609, 745815, 745737

-

Product in Enzyme-catalyzed Reactions (5 results)

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Show Product (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.337

a 2-oxocarboxylate + NADH + H+ = (2S)-2-hydroxycarboxylate + NAD+

0

-

3.8.1.10

(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide

0

-

3.8.1.11

(S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide

0

-

3.8.1.2

DL-2-haloalkanoic acid + H2O = L-2-hydroxyalkanoic acid + D-2-hydroxyalkanoic acid + halide

0

-

3.8.1.9

(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide

0

-

Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

287559

5443694

2-Hydroxy fatty acid oxidases of rat kidney

1970

Levis, G.M.

Biochem. Biophys. Res. Commun.

38

470-477

745481

26658681

The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival

2016

Mattu, S.; Fornari, F.; Quagliata, L.; Perra, A.; Angioni, M.M.; Petrelli, A.; Menegon, S.; Morandi, A.; Chiarugi, P.; Ledda-Columbano, G.M.; Gramantieri, L.; Terracciano, L.; Giordano, S.; Columbano, A.

J. Hepatol.

64

891-898

745609

24801764

MD and QM/MM studies on long-chain L-alpha-hydroxy acid oxidase substrate binding features and oxidation mechanism

2014

Cao, Y.; Han, S.; Yu, L.; Qian, H.; Chen, J.Z.

J. Phys. Chem. B

118

5406-5417

745737

24408912

Plant and animal glycolate oxidases have a common eukaryotic ancestor and convergently duplicated to evolve long-chain 2-hydroxy acid oxidases

2014

Esser, C.; Kuhn, A.; Groth, G.; Lercher, M.J.; Maurino, V.G.

Mol. Biol. Evol.

31

1089-1101

745815

26758691

Inhibition of glycolate oxidase with dicer-substrate siRNA reduces calcium oxalate deposition in a mouse model of primary hyperoxaluria type 1

2016

Dutta, C.; Avitahl-Curtis, N.; Pursell, N.; Larsson Cohen, M.; Holmes, B.; Diwanji, R.; Zhou, W.; Apponi, L.; Koser, M.; Ying, B.; Chen, D.; Shui, X.; Saxena, U.; Cyr, W.A.; Shah, A.; Nazef, N.; Wang, W.; Abrams, M.; Dudek, H.; Salido, E.; Brown, B.D.; Lai, C.

Mol. Ther.

24

770-778

Links to other databases for (S)-2-hydroxyacid

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Show Links (1 entry)