Ligand CDP

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Basic Ligand Information

Molecular Structure
Picture of CDP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H15N3O11P2
CDP
ZWIADYZPOWUWEW-XVFCMESISA-N
Synonyms:
5'-CDP, cytidine-5'-diphosphate, cytidine 5'-diphosphate, D-CDP


Show all pahtways known for Show all BRENDA pathways known for CDP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP + H2O = CMP + phosphate
show the reaction diagram
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CDP + H2O = CMP + phosphate
show the reaction diagram
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CDP + H2O = CMP + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP-abequose + mannosyl-rhamnosyl-galactose-1-diphospholipid = CDP + abequosyl-mannosyl-rhamnosyl-galactose-1-diphospholipid
show the reaction diagram
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CTP + dolichol = CDP + dolichyl phosphate
show the reaction diagram
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CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
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CTP + phytol = CDP + phytyl phosphate
show the reaction diagram
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ATP + CMP = ADP + CDP
show the reaction diagram
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ATP + CMP = ADP + CDP
show the reaction diagram
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CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-((2R)-1-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O + polypeptide = CDP + phosphate + unfolded polypeptide
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (138 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha,alpha-trehalose + CDP = CDP-alpha-D-glucose + D-glucose
show the reaction diagram
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dimethylallyl diphosphate + CDP = ?
show the reaction diagram
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dimethylallyl diphosphate + CDP = ?
show the reaction diagram
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CDP + D-glucose = CMP + D-glucose 6-phosphate
show the reaction diagram
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CDP + phosphoenolpyruvate = CTP + pyruvate
show the reaction diagram
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CDP + phosphoramide = CTP + NH3
show the reaction diagram
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CDP + phosphate = phosphate + CDP
show the reaction diagram
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poly(C) + CDP = poly(C)+1 + phosphate
show the reaction diagram
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CDP + H2O = CMP + phosphate
show the reaction diagram
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glucose + CDP = glucose 6-phosphate + CMP
show the reaction diagram
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CDP + H2O = CMP + phosphate
show the reaction diagram
-
CDP + H2O = CMP + phosphate
show the reaction diagram
-
CDP + H2O = ?
show the reaction diagram
-
CDP + H2O = CMP + phosphate
show the reaction diagram
-
adenosine 5'-phosphoimidazolide + CDP = imidazole + A(5')p3(5')C
show the reaction diagram
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CDP + H2O = CMP + phosphate
show the reaction diagram
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CDP + H2O = cytidine + diphosphate
show the reaction diagram
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CDP + H2O = ?
show the reaction diagram
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CDP + phosphate + acetyl-CoA = CTP + acetate + CoA
show the reaction diagram
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ATP + CDP = P1-(5'-adenosyl),P3-(5'-cytidyl)triphosphate + diphosphate
show the reaction diagram
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CDP + phosphate + Na+/out = CTP + H2O + Na+/in
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (245 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP-glucose + D-fructose = CDP + sucrose
show the reaction diagram
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CDP-glucose + D-glucose 6-phosphate = trehalose 6-phosphate + CDP
show the reaction diagram
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CDP-glucose + hydroquinone = CDP + hydroquinone-O-beta-D-glucopyranoside
show the reaction diagram
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CDP-glucose + (1,4-alpha-glucosyl)n = CDP + ?
show the reaction diagram
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CDP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + CDP
show the reaction diagram
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CDP-glucose + p-nitrophenol = CDP + p-nitrophenyl beta-D-glucoside
show the reaction diagram
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CDP-glucose + N-acylsphingosine = CDP + D-glucosyl-N-acylsphingosine
show the reaction diagram
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CTP + D-glucose = CDP + D-glucose 6-phosphate
show the reaction diagram
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CTP + 5-methylthioribose = CDP + 5-methylthioribose 1-phosphate
show the reaction diagram
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CTP + D-fructose 6-phosphate = CDP + beta-D-fructose 2,6-bisphosphate
show the reaction diagram
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CTP + D-fructose 6-phosphate = CDP + D-fructose 1,6-bisphosphate
show the reaction diagram
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CTP + D-gluconate = CDP + 6-phospho-D-gluconate
show the reaction diagram
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CTP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = CDP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
show the reaction diagram
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CTP + D-tagatose 6-phosphate = CDP + D-tagatose 1,6-bisphosphate
show the reaction diagram
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CTP + D-ribose = CDP + D-ribose 5-phosphate
show the reaction diagram
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CTP + L-seryl-tRNASec = CDP + O-phospho-L-seryl-tRNASec
show the reaction diagram
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3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CTP = 3-deoxy-4-O-phosphono-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CDP
show the reaction diagram
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CTP + pantoate = CDP + 4-phosphopantoate
show the reaction diagram
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CTP + 1-deoxy-D-xylulose = CDP + 1-deoxy-D-xylulose 5-phosphate
show the reaction diagram
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CTP + phytol = CDP + phytyl phosphate
show the reaction diagram
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CTP + D-glucose = CDP + D-glucose 6-phosphate
show the reaction diagram
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CTP + adenosine = CDP + AMP
show the reaction diagram
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cytidine + CTP = CMP + CDP
show the reaction diagram
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CTP + (2E,6E)-farnesol = CDP + (2E,6E)-farnesyl phosphate
show the reaction diagram
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CTP + adenosine 5-phosphosulfate = CDP + 3'-phosphoadenosine 5'-phosphosulfate
show the reaction diagram
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CTP + dihydroxyacetone = CDP + dihydroxyacetone phosphate
show the reaction diagram
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CTP + glycerol = CDP + glycerol 3-phosphate
show the reaction diagram
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CTP + choline = CDP + choline phosphate
show the reaction diagram
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CTP + D-fructose = CDP + D-fructose 6-phosphate
show the reaction diagram
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CTP + 2-dehydro-3-deoxy-D-gluconate = CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
show the reaction diagram
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CTP + 5-hydroxy-2-methylpyrimidine = CDP + 2-methyl-5-phosphopyrimidine
show the reaction diagram
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CTP + 4-methyl-5-(2-hydroxyethyl)thiazole = CDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
show the reaction diagram
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CTP + 6-deoxy-L-galactose = CDP + 6-deoxy-L-galactose 1-phosphate
show the reaction diagram
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CTP + D-arabinose = CDP + D-arabinose 5-phosphate
show the reaction diagram
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CTP + D-fructose 1-phosphate = CDP + D-fructose 1,6-bisphosphate
show the reaction diagram
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CTP + N-acetyl-D-glucosamine = CDP + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
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CTP + D-galactose = CDP + alpha-D-galactose 1-phosphate
show the reaction diagram
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CTP + myo-inositol = CDP + myo-inositol 1-phosphate
show the reaction diagram
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CTP + 1-phosphatidyl-1D-myo-inositol = CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
show the reaction diagram
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CTP + inosine = CDP + IMP
show the reaction diagram
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CTP + cellobiose = CDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
show the reaction diagram
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CTP + NADH = CDP + NADPH
show the reaction diagram
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CTP + geranylgeraniol = CDP + geranylgeranyl phosphate
show the reaction diagram
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CTP + inosine = CDP + inosine 5'-phosphate
show the reaction diagram
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CTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = CDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
show the reaction diagram
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CTP + acetate = CDP + acetyl phosphate
show the reaction diagram
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CTP + isobutanoate = CDP + isobutanoyl phosphate
show the reaction diagram
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CTP + propanoate = CDP + propanoyl phosphate
show the reaction diagram
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CTP + formate = CDP + formyl phosphate
show the reaction diagram
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CTP + AMP = CDP + ADP
show the reaction diagram
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CTP + thiamine diphosphate = CDP + thiamine triphosphate
show the reaction diagram
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GMP + trans-farnesyl diphosphate = CDP + trans-farnesyl triphosphate
show the reaction diagram
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CTP + (R,S)-5-phosphomevalonate = CDP + (R,S)-5-diphosphomevalonate
show the reaction diagram
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CTP + (2E,6E)-farnesyl phosphate = CDP + (2E,6E)-farnesyl diphosphate
show the reaction diagram
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CTP + dTMP = CDP + dTDP
show the reaction diagram
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CTP + UMP = CDP + UDP
show the reaction diagram
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CMP + [phosphate]n = CDP + [phosphate]n-1
show the reaction diagram
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CDP + phosphate = phosphate + CDP
show the reaction diagram
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P1(5'-adenosyl)-P4(5'-cytosyl) tetraphosphate + phosphate = CDP + ATP
show the reaction diagram
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CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-((2R)-1-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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5'-CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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glucose + CTP = glucose 6-phosphate + CDP
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
-
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CTP + H2O = CDP + phosphate
show the reaction diagram
-
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
-
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + 5-diphosphomevalonate = CDP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
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CTP + oxaloacetate = CDP + phosphoenolpyruvate + CO2
show the reaction diagram
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CTP + H2O + a dynein associated with a microtubule at position n = CDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
show the reaction diagram
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CTP + H2O + polypeptide = CDP + phosphate + unfolded polypeptide
show the reaction diagram
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CTP + H2O + closed Cl- channel = CDP + phosphate + open Cl- channel
show the reaction diagram
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CTP + acetate + CoA = CDP + phosphate + acetyl-CoA
show the reaction diagram
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CTP + diphthine + ammonia = CDP + phosphate + diphthamide
show the reaction diagram
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CTP + D-Ala + membrane-acceptor = CDP + phosphate + D-alanyl-membrane acceptor
show the reaction diagram
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CTP + 5,6,7,8-tetrahydropteroyl-Glu + Glu = CDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2
show the reaction diagram
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CTP + gamma-Glu-L-Cys + Gly = CDP + phosphate + glutathione
show the reaction diagram
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CTP + (R)-4'-phosphopantothenate + L-Cys = (R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
show the reaction diagram
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CTP + 5-formyltetrahydrofolate = CDP + phosphate + 5,10-methylenetetrahydrofolate
show the reaction diagram
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CTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate = CDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate
show the reaction diagram
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CTP + hydrogenobyrinic acid a,c-diamide + Co2+ = CDP + phosphate + cob(II)yrinic acid a,c-diamide + H+
show the reaction diagram
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CTP + H2O + H+/in = CDP + phosphate + H+/out
show the reaction diagram
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CTP + H2O + Ca2+[side 1] = CDP + phosphate + Ca2+[side 2]
show the reaction diagram
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CTP + H2O + H+/in + K+/out = CDP + phosphate + H+/out + K+/in
show the reaction diagram
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CTP + H2O + phosphate/out = CDP + phosphate + phosphate/in
show the reaction diagram
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CTP + H2O + His/out = CDP + phosphate + His/in
show the reaction diagram
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CTP + H2O + peptide/out = CDP + phosphate + peptide/in
show the reaction diagram
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spermidine/out + CTP + H2O = spermidine/in + CDP + phosphate
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
enhances activity
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
allosteric activator
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activation
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stimulates
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low activation, allosteric activator
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Inhibitor in Enzyme-catalyzed Reactions (101 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor with respect to CDP-3,6-dideoxy-D-glycero-D-glycero-4-hexulose and either an uncompetitive or a mixed type inhibitor with respect to NADPH
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renal enzyme, 90% inhibition at 0.025 mM
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slight inhibition at 3-5 mM
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1 mM, 10% inhibition
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23% residual activity at 10 mg/ml
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less effective than CTP
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less effective than CTP
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only partially relieved by excess Mg2+
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1 mM, 33% inhibition
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with ATP as substrate
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4.9 mM, 16% inhibition in presence of ATP
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strong
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50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+
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preincubation of acetate kinase with MgCl2, AlCl3, NaF, acetate, and either IDP, UDP, or CDP in place of ADP results in almost complete inhibition of activity
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weak
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inhibits uridylyl removing activity
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strong inhibition
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50% inhibition at 400 mM; inhibition is completely reversed by Mg2+
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64% inhibition at 0.86 mM
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50% inhibition at 0.1 mM
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competitive inhibition, Ki: 0.0085 mM
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0.2 mM, 29% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (44 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.167
-
pH 7.2, 37°C
58
-
-
4.83
-
+/- 0.39
4.83
-
+/- 0.39
51.3
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at pH 9.5 and 95°C
1.67
-
substrate concentration between 0.01 and 4.0 mM, 37°C
89
-
pH 4.5, 37°C

KM Value (43 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.11
-
presence of effector dATP
2.1
-
pH 9.0, 37°C, reaction with N-acetylneuraminate
1
-
pH 9.5, 37°C, approx. value
0.606
-
-
0.093
-
-
0.53
-
+/- 0.09
0.53
-
+/- 0.09
3.12
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at pH 9.5 and 95°C
0.777
-
pH 7.5, 37°C, presence of Mg2+
1.9
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pH 4.5, 37°C

Ki Value (16 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
-999
-
Ki value is above 9 mM, UDP-galactose 0.1-16 mM, 0-10 mM CDP
3.1
-
-
0.06
-
pH 7.5, 25°C
0.121
-
pH 7.2, 37°C
2.9
-
pH 7.8, 28°C
0.24
-
pH 7.2, 37°C
4
-
pH 9.0, 37°C
0.0085
-
competitive inhibition

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
-999
-
1 mM, 37°C, pH 8.5, 15 min, 14% inhibition
2.6
-
-

References & Links

Links to other databases for CDP

ChEBI
PubChem
ChEBI
PubChem