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Inhibitors of the NAD(+)-dependent protein desuccinylase and demalonylase Sirt5
2012
Maurer, B.; Rumpf, T.; Scharfe, M.; Stolfa, D.A.; Schmitt, M.L.; He, W.; Verdin, E.; Sippl, W.; Jung, M.
ACS Med. Chem. Lett.
3
1050-1053
Studying SIRT6 regulation using H3K56 based substrate and small molecules
2014
Kokkonen, P.; Rahnasto-Rilla, M.; Mellini, P.; Jarho, E.; Lahtela-Kakkonen, M.; Kokkola, T.
Eur. J. Pharm. Sci.
63
71-76
The 2.5 A crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition
2013
Zhao, X.; Allison, D.; Condon, B.; Zhang, F.; Gheyi, T.; Zhang, A.; Ashok, S.; Russell, M.; MacEwan, I.; Qian, Y.; Jamison, J.A.; Luz, J.G.
J. Med. Chem.
56
963-969
Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-cell chronic lymphocytic leukemia (CLL)
2016
Bhalla, S.; Gordon, L.I.
Cancer Biol. Ther.
17
300-309
Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells
2015
Fang, M.; Guo, W.R.; Park, Y.; Kang, H.G.; Zarbl, H.
Oncotarget
6
42879-42891
-
Amberlyst-15 catalyzed Povarov reaction of N-arylidene-1H-indazol-6-amines and indoles: a greener approach to the synthesis of exo-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinolines as potential sirtuin inhibitors
2015
Pasha, J.; Kandagatla, B.; Sen, S.; Seerapu, G.; Bujji, S.; Haldar, D.; Nanduri, S.; Oruganti, S.
Tetrahedron Lett.
56
2289-2292
Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening
2017
Morreale, F.E.; Bortoluzzi, A.; Chaugule, V.K.; Arkinson, C.; Walden, H.; Ciulli, A.
J. Med. Chem.
60
4093-4098
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