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Ligand 5-methyltetrahydrofolate

Basic Ligand Information

Molecular Structure

Related pathways

Pathway Source

Pathways

BRENDA

reductive acetyl coenzyme A pathway, tetrahydrofolate metabolism

KEGG

Antifolate resistance, Carbon fixation pathways in prokaryotes, Carbon metabolism, Microbial metabolism in diverse environments, One carbon pool by folate

MetaCyc

dimethylsulfoniopropanoate degradation III (demethylation), folate transformations I, folate transformations II (plants), folate transformations III (E. coli), glycine betaine degradation IV, L-carnitine degradation IV, L-methionine biosynthesis I, L-methionine biosynthesis III, L-methionine salvage from L-homocysteine, methoxylated aromatic compound degradation I, methylthiopropanonate degradation II (demethylation), proline betaine degradation II, reductive acetyl coenzyme A pathway I (homoacetogenic bacteria), syringate degradation, vanillin and vanillate degradation I more

Show all BRENDA pathways known for 5-methyltetrahydrofolate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (13 results)

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Show Natural Substrate (13 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.20

5-methyltetrahydrofolate + NAD+ = 5,10-methylenetetrahydrofolate + NADH

654771

3FSU, 3D-view

1.5.1.20

5-methyltetrahydrofolate + NAD+ = 5,10-methylenetetrahydrofolate + NADH

654771

7XLF, 3D-view

1.5.1.20

5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH

657415

3FSU, 3D-view

1.5.1.20

5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH

657415

7XLF, 3D-view

1.5.1.20

4 entries

1.5.1.53

5-methyltetrahydrofolate + oxidized menadione = 5,10-methylenetetrahydrofolate + reduced menadione

760548, 392157

-

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

437712, 441173, 660282, 658413, 774007, 779091, 779181, 777122, 777258, 777927, 778408, 778596, 778708, 778733, 778732

1Q8J, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

657836

1Q8J, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

1U1J, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

1XPG, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

1XR2, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

4L64, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

4L65, 3D-view

2.1.1.13

2 entries

2.1.1.14

5 entries

2.1.1.258

a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate = a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate

776252

-

In Vivo Product in Enzyme-catalyzed Reactions (29 results)

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Show Natural Product (29 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.20

(6R)-5,10-methylenetetrahydrofolate + NAD(P)H + H+ = (6S)-5-methyltetrahydrofolate + NAD(P)+

-

3FSU, 3D-view

1.5.1.20

(6R)-5,10-methylenetetrahydrofolate + NAD(P)H + H+ = (6S)-5-methyltetrahydrofolate + NAD(P)+

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + FADH2 = 5-methyltetrahydrofolate + FAD

437714, -

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + FADH2 = 5-methyltetrahydrofolate + FAD

437714, -

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + ferredoxin = 5-methyltetrahydrofolate + reduced ferredoxin

-

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + ferredoxin = 5-methyltetrahydrofolate + reduced ferredoxin

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NAD(P)H + H+ = 5-methyltetrahydrofolate + NAD(P)+

-

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NAD(P)H + H+ = 5-methyltetrahydrofolate + NAD(P)+

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADH = 5-methyltetrahydrofolate + NAD+

437724, 437716, -

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADH = 5-methyltetrahydrofolate + NAD+

437724, 437716, -

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADPH + H+ = 5-methyltetrahydrofolate + NADP+

-

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADPH + H+ = 5-methyltetrahydrofolate + NADP+

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADPH = 5-methyltetrahydrofolate + NADP+

437725, 437727

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADPH = 5-methyltetrahydrofolate + NADP+

437725, 437727

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + reduced acceptor = 5-methyltetrahydrofolate + oxidized acceptor

437720, 437719, 437721, 437723

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + reduced acceptor = 5-methyltetrahydrofolate + oxidized acceptor

437720, 437719, 437721, 437723

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + reduced ferredoxin = 5-methyltetrahydrofolate + oxidized ferredoxin

437714, 437713

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + reduced ferredoxin = 5-methyltetrahydrofolate + oxidized ferredoxin

437714, 437713

7XLF, 3D-view

1.5.1.20

18 entries

1.5.1.53

5,10-methylenetetrahydrofolate + NADPH + H+ = 5-methyltetrahydrofolate + NADP+

-

-

1.5.1.54

5,10-methylenetetrahydrofolate + NADH + H+ = 5-methyltetrahydrofolate + NAD+

-

-

2.1.1.269

2-(dimethylsulfonio)propanoate + tetrahydrofolate = 2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate

-

-

2.1.1.269

S,S-dimethyl-beta-propiothetin + tetrahydrofolate = 3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate

-

-

2.1.1.341

3-O-methylgallate + tetrahydrofolate = gallate + 5-methyltetrahydrofolate

-

-

2.1.1.341

syringate + tetrahydrofolate = 3-O-methylgallate + 5-methyltetrahydrofolate

-

-

2.1.1.341

vanillate + tetrahydrofolate = 3,4-dihydroxybenzoate + 5-methyltetrahydrofolate

-

-

2.1.1.341

vanillate + tetrahydrofolate = protocatechuate + 5-methyltetrahydrofolate

-

-

2.1.1.389

a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + tetrahydrofolate = N5-methyltetrahydrofolate + a [Co(I) quaternary-amine-specific corrinoid protein]

-

-

2.1.1.389

[methyl-Co(III) quaternary-amine-specific corrinoid protein MtqC ] + tetrahydrofolate = N5-methyltetrahydrofolate + [Co(I) quaternary-amine-specific corrinoid protein MtqC]

-

-

2.1.1.389

[methyl-Co(III) quaternary-amine-specific corrinoid protein MtqC] + tetrahydrofolate = N5-methyltetrahydrofolate + [Co(I) quaternary-amine-specific corrinoid protein MtqC]

-

-

2.1.1.269

2 entries

2.1.1.341

4 entries

2.1.1.389

3 entries

Substrate in Enzyme-catalyzed Reactions (40 results)

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Show Substrate (40 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.20

5-methyltetrahydrofolate + NAD+ = 5,10-methylenetetrahydrofolate + NADH

654771, 674719

3FSU, 3D-view

1.5.1.20

5-methyltetrahydrofolate + NAD+ = 5,10-methylenetetrahydrofolate + NADH

654771, 674719

7XLF, 3D-view

1.5.1.20

5-methyltetrahydrofolate + NAD+ = 5,10-methylenetetrahydrofolate + NADH + H+

437717, 437714, 437713

3FSU, 3D-view

1.5.1.20

5-methyltetrahydrofolate + NAD+ = 5,10-methylenetetrahydrofolate + NADH + H+

437717, 437714, 437713

7XLF, 3D-view

1.5.1.20

5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH

657415, 654695, 674719

3FSU, 3D-view

1.5.1.20

5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH

657415, 654695, 674719

7XLF, 3D-view

1.5.1.20

5-methyltetrahydrofolate + oxidized menadione = 5,10-methylenetetrahydrofolate + reduced menadione

392157, 392149, 392153, 392155, 674719

3FSU, 3D-view

1.5.1.20

5-methyltetrahydrofolate + oxidized menadione = 5,10-methylenetetrahydrofolate + reduced menadione

392157, 392149, 392153, 392155, 674719

7XLF, 3D-view

1.5.1.20

8 entries

1.5.1.53

5-methyltetrahydrofolate + oxidized menadione = 5,10-methylenetetrahydrofolate + reduced menadione

760548, 392157, 392149, 760550

-

1.5.1.54

5-methyltetrahydrofolate + menadione = 5,10-methylenetetrahydrofolate + menadiol

437726, 761372, 437724

-

1.5.1.54

5-methyltetrahydrofolate + methylene blue = 5,10-methylenetetrahydrofolate + reduced methylene blue

761018

-

1.5.7.1

5-methyltetrahydrofolate + 2 benzyl viologen = 5,10-methylenetetrahydrofolate + 2 reduced benzyl viologen + 2 H+

742782

-

1.5.7.1

5-methyltetrahydrofolate + 2 oxidized ferredoxin = 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin + 2 H+

764936

-

1.5.7.1

5-methyltetrahydrofolate + benzyl viologen = 5,10-methylenetetrahydrofolate + reduced benzyl viologen

437714

-

1.5.7.1

5-methyltetrahydrofolate + FAD = 5,10-methylenetetrahydrofolate + FADH2

437714

-

1.5.7.1

5-methyltetrahydrofolate + menadione = 5,10-methylenetetrahydrofolate + reduced menadiol

437714

-

1.5.7.1

5-methyltetrahydrofolate + rubredoxin = 5,10-methylenetetrahydrofolate + reduced rubredoxin

437714

-

2.1.1.13

5-methyltetrahydrofolate + 2-mercaptoethanol = S-methylmercaptoethanol + tetrahydrofolate

441183

1Q8J, 3D-view

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

437712, 441173, 660282, 658413, 441188, 441183, 774007, 779091, 779181, 777122, 777258, 777927, 778408, 778596, 778708, 778733, 778732

1Q8J, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

441177, 441178, 441179, 441188, 441192, 437717, 441194, 441189, 657836

1Q8J, 3D-view

2.1.1.13

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441173, 441183, 441172, 441174, 437717, 437712, 441194, 676875, 673604, 673596, 672821, 684467, 702050, 703638, 704166, 700779, 706520, 706495, 706493, 441185

1Q8J, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

1U1J, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

1XPG, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

1XR2, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

4L64, 3D-view

2.1.1.14

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

779071

4L65, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

671122, 441322

1U1J, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

671122, 441322

1XPG, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

671122, 441322

1XR2, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

671122, 441322

4L64, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

671122, 441322

4L65, 3D-view

2.1.1.258

a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate = a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate

776252

-

2.1.1.258

cobalamin + 5-methyltetrahydrofolate = methylcobalamin + tetrahydrofolate

728242

-

2.1.1.258

hydroxocobalamin + 5-methyltetrahydrofolate = methylcobalamin + tetrahydrofolate

718823

-

2.1.1.258

hydroxycobalamin + 5-methyltetrahydrofolate = methylcobalamin + tetrahydrofolate

720970

-

2.1.1.258

[Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate = [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate

721068, 719685, 717236, 718823, 718824, 719846, 720305, 720970

-

1.5.1.54

2 entries

1.5.7.1

6 entries

2.1.1.13

4 entries

2.1.1.14

10 entries

2.1.1.258

5 entries

3.4.17.11

5-methyltetrahydrofolate + H2O = 5-methylpteroate + Glu

647248, 647246, 647247, 647244

-

6.3.2.17

ATP + (6S)-5-methyl-5,6,7,8-tetrahydropteroylglutamate + L-glutamate = ADP + phosphate + (6S)-5-methyl-5,6,7,8-tetrahydropteroyl-Glu2

650131

-

6.3.2.17

ATP + (6S)-5-methyl-5,6,7,8-tetrahydropteroylglutamate + L-glutamate = ADP + phosphate + (6S)-5-methyl-5,6,7,8-tetrahydropteroyldiglutamate

650131

-

6.3.2.17

2 entries

7.2.1.4

N5-methyltetrahydrofolate + 2-mercaptoethanesulfonate = ?

727407

-

Product in Enzyme-catalyzed Reactions (54 results)

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Show Product (54 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.20

(6R)-5,10-methylenetetrahydrofolate + NAD(P)H + H+ = (6S)-5-methyltetrahydrofolate + NAD(P)+

-

3FSU, 3D-view

1.5.1.20

(6R)-5,10-methylenetetrahydrofolate + NAD(P)H + H+ = (6S)-5-methyltetrahydrofolate + NAD(P)+

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + acceptor = 5-methyltetrahydrofolate + reduced acceptor

-

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + acceptor = 5-methyltetrahydrofolate + reduced acceptor

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + FADH2 = 5-methyltetrahydrofolate + FAD

437714, -

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + FADH2 = 5-methyltetrahydrofolate + FAD

437714, -

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + ferredoxin = 5-methyltetrahydrofolate + reduced ferredoxin

-

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + ferredoxin = 5-methyltetrahydrofolate + reduced ferredoxin

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NAD(P)H + H+ = 5-methyltetrahydrofolate + NAD(P)+

-

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NAD(P)H + H+ = 5-methyltetrahydrofolate + NAD(P)+

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NAD(P)H = 5-methyltetrahydrofolate + NAD(P)+

-

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NAD(P)H = 5-methyltetrahydrofolate + NAD(P)+

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADH + H+ = 5-methyltetrahydrofolate + NAD+

-

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADH + H+ = 5-methyltetrahydrofolate + NAD+

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADH = 5-methyltetrahydrofolate + NAD+

437724, 437716, -

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADH = 5-methyltetrahydrofolate + NAD+

437724, 437716, -

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADPH + H+ = 5-methyltetrahydrofolate + NADP+

-

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADPH + H+ = 5-methyltetrahydrofolate + NADP+

-

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADPH = 5-methyltetrahydrofolate + NADP+

- , 437725, 437727

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + NADPH = 5-methyltetrahydrofolate + NADP+

- , 437725, 437727

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + reduced acceptor = 5-methyltetrahydrofolate + oxidized acceptor

437719, 437722, 437723, 437715, 437712, 437720, 437711, 437713, 437714, 437717, 437727, 437724, 437726, 437721, 437716, 437725, -

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + reduced acceptor = 5-methyltetrahydrofolate + oxidized acceptor

437719, 437722, 437723, 437715, 437712, 437720, 437711, 437713, 437714, 437717, 437727, 437724, 437726, 437721, 437716, 437725, -

7XLF, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + reduced ferredoxin = 5-methyltetrahydrofolate + oxidized ferredoxin

437714, 437713

3FSU, 3D-view

1.5.1.20

5,10-methylenetetrahydrofolate + reduced ferredoxin = 5-methyltetrahydrofolate + oxidized ferredoxin

437714, 437713

7XLF, 3D-view

1.5.1.53

5,10-methylenetetrahydrofolate + NADH + H+ = 5-methyltetrahydrofolate + NAD+

-

-

1.5.1.53

5,10-methylenetetrahydrofolate + NADPH + H+ = 5-methyltetrahydrofolate + NADP+

-

-

1.5.1.53

5,10-methylenetetrahydrofolate + NADPH = 5-methyltetrahydrofolate + NADP+

-

-

1.5.1.54

5,10-methylenetetrahydrofolate + menadiol = 5-methyltetrahydrofolate + menadione

-

-

1.5.1.54

5,10-methylenetetrahydrofolate + NADH + H+ = 5-methyltetrahydrofolate + NAD+

-

-

1.5.1.54

5,10-methylenetetrahydrofolate + NADPH + H+ = 5-methyltetrahydrofolate + NADP+

-

-

1.5.1.54

5,10-methylenetetrahydrofolate + reduced methylene blue = 5-methyltetrahydrofolate + methylene blue

-

-

1.5.1.20

24 entries

1.5.1.53

3 entries

1.5.1.54

4 entries

1.5.7.1

5,10-methylenetetrahydrofolate + reduced ferredoxin = 5-methyltetrahydrofolate + ferredoxin

-

-

2.1.1.13

S-adenosyl-L-methionine + tetrahydrofolate = 5-methyltetrahydrofolate + S-adenosyl-L-homocysteine

441183

1Q8J, 3D-view

2.1.1.19

trimethylsulfonium + tetrahydrofolate = dimethylsulfide + 5-methyltetrahydrofolate

485198

-

2.1.1.258

methylcobalamin + tetrahydrofolate = hydroxocobalamin + 5-methyltetrahydrofolate

-

-

2.1.1.258

[methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate = [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate

-

-

2.1.1.269

2-(dimethylsulfonio)propanoate + tetrahydrofolate = 2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate

-

-

2.1.1.269

2-(dimethylsulfonio)propanoate + tetrahydrofolate = 2-(methylthio)propanoate + 5-methyltetrahydrofolate

-

-

2.1.1.269

3-(S,S-dimethylsulfonio)propanoate + tetrahydrofolate = 3-(methylthio)propanoate + 5-methyltetrahydrofolate

-

-

2.1.1.269

S,S-dimethyl-beta-propiothetin + tetrahydrofolate = 3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate

-

-

2.1.1.341

syringate + 2 tetrahydrofolate = protocatechuate + 2 5-methyltetrahydrofolate

-

-

2.1.1.341

3-O-methylgallate + tetrahydrofolate = gallate + 5-methyltetrahydrofolate

-

-

2.1.1.341

syringate + tetrahydrofolate = 3-O-methylgallate + 5-methyltetrahydrofolate

-

-

2.1.1.341

vanillate + tetrahydrofolate = 3,4-dihydroxybenzoate + 5-methyltetrahydrofolate

-

-

2.1.1.341

vanillate + tetrahydrofolate = protocatechuate + 5-methyltetrahydrofolate

-

-

2.1.1.258

2 entries

2.1.1.269

4 entries

2.1.1.341

5 entries

2.1.1.378

methyl-cob(III)alamin + tetrahydrofolate = cob(II)alamin + 5-methyltetrahydrofolate

-

-

2.1.1.385

[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein MtvC] + tetrahydrofolate = N5-methyltetrahydrofolate + [Co(I) methoxylated-aromatic-compound-specific corrinoid protein MtvC]

-

-

2.1.1.385

[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein] + tetrahydrofolate = N5-methyltetrahydrofolate + [Co(I) methoxylated-aromatic-compound-specific corrinoid protein]

-

-

2.1.1.389

a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + tetrahydrofolate = N5-methyltetrahydrofolate + a [Co(I) quaternary-amine-specific corrinoid protein]

-

-

2.1.1.389

[methyl-Co(III) quaternary-amine-specific corrinoid protein MtqC ] + tetrahydrofolate = N5-methyltetrahydrofolate + [Co(I) quaternary-amine-specific corrinoid protein MtqC]

-

-

2.1.1.389

[methyl-Co(III) quaternary-amine-specific corrinoid protein MtqC] + tetrahydrofolate = N5-methyltetrahydrofolate + [Co(I) quaternary-amine-specific corrinoid protein MtqC]

-

-

3.4.19.9

5-methyltetrahydrofolate glutamate + H2O = 5-methyltetrahydrofolate + L-glutamate

-

-

3.4.19.9

5-methyltetrahydrofolate heptaglutamate + 7 H2O = 5-methyltetrahydrofolate + 7 L-glutamate

-

-

3.4.19.9

5-methyltetrahydrofolate hexaglutamate + 6 H2O = 5-methyltetrahydrofolate + 6 L-glutamate

-

-

2.1.1.385

2 entries

2.1.1.389

3 entries

3.4.19.9

3 entries

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.136

1 mM, activation to 119% of control

657589

-

Inhibitor in Enzyme-catalyzed Reactions (21 results)

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Show Inhibitors (21 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.3

-

392254

-

1.5.1.53

-

392157

-

2.1.1.14

-

441323

1U1J, 3D-view

2.1.1.14

-

441323

1XPG, 3D-view

2.1.1.14

-

441323

1XR2, 3D-view

2.1.1.14

-

441323

4L64, 3D-view

2.1.1.14

-

441323

4L65, 3D-view

2.1.1.20

-

706903

2IDK, 3D-view

2.1.1.20

-

706903

3THR, 3D-view

2.1.1.20

-

674879

2IDK, 3D-view

2.1.1.20

-

674879

3THR, 3D-view

2.1.1.20

-

485216

2IDK, 3D-view

2.1.1.20

-

485216

3THR, 3D-view

2.1.1.14

5 entries

2.1.1.20

6 entries

2.1.1.341

competitive with respect to tetrahydrofolate, noncompetitive with respect to vanillate

741347

-

2.1.2.1

-

441407

7X5O, 3D-view

2.1.2.13

-

757485

-

2.1.2.9

most effective, non-competitive inhibitor

485801

-

2.3.1.48

ZINC34633488

756646

-

2.7.7.B24

-

741002

-

6.3.3.2

-

1321

-

6.3.3.2

competitive with respect to 5-formyltetrahydrofolate

1329

-

6.3.3.2

2 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (251 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (251 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

3FSU, 3D-view

1.5.1.20

7XLF, 3D-view

1.5.1.20

26 entries

1.7.99.5

1ZP4, 3D-view

2.1.1.13

1Q8J, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.14

1U1J, 3D-view

2.1.1.14

1XPG, 3D-view

2.1.1.14

1XR2, 3D-view

2.1.1.14

4L64, 3D-view

2.1.1.14

4L65, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.20

2IDK, 3D-view

2.1.1.20

3THR, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.45

1B02, 3D-view

2.1.1.45

1TLS, 3D-view

2.1.1.45

1TSN, 3D-view

2.1.1.45

4FOG, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.86

6SJN, 3D-view

2.1.1.86

6SJO, 3D-view

2.1.1.86

6SJR, 3D-view

2.1.1.86

6SJS, 3D-view

2.1.1.14

65 entries

2.1.1.20

26 entries

2.1.1.45

52 entries

2.1.1.86

52 entries

2.1.2.1

7X5O, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

1WSV, 3D-view

2.1.2.10

3A8I, 3D-view

2.1.2.10

26 entries

2.1.2.2

3DCJ, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (3 results)

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Show Turnover Number (3 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.1.1.13

8.33

13

-

441183

2.1.1.258

1.5

-

using hydroxocobalamin as cosubstrate, in 1 mM Tris-HCl (pH 7.6), at 25°C

718823

2.1.1.258

14.7

-

in 50 mM MES, pH 5.1, at 25°C

717236

2.1.1.258

2 entries

K_M Value (30 results)

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Show KM Value (30 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.5.1.20

0.019

-

-

437721

1.5.1.20

0.023

-

-

437717

1.5.1.20

0.038

-

5,10-methylenetetrahydrofolate-oxidoreductase reaction

392157

1.5.1.20

0.06

0.08

fresh extract

437716

1.5.1.20

0.085

-

wild-type enzyme

437726

1.5.1.20

0.12

-

-

437713, 437714

1.5.1.20

0.16

-

D120N mutant enzyme

437726

1.5.1.20

7 entries

1.5.1.53

0.038

-

pH not specified in the publication, temperature not specified in the publication

392157

1.5.1.54

0.075

-

pH 7.2, 15°C

761372

1.5.1.54

0.085

-

wild-type, cosubstrate menadione, pH 7.2, 25°C

437726

1.5.1.54

0.106

-

mutant D120N, cosubstrate menadione, pH 7.2, 25°C

437726

1.5.7.1

0.01

-

-

437714

1.5.7.1

1.8

-

pH 7.5, 45°C, recombinant enzyme, with benzyl viologen

742782

2.1.1.13

0.013

-

-

437717

2.1.1.13

0.025

-

in 50 mM phosphate buffer, pH 7.4, at 37°C

673596

2.1.1.13

0.03

-

-

441183

2.1.1.13

0.035

-

-

441178

2.1.1.13

0.06

-

-

441188

2.1.1.13

0.0731

-

-

441194

2.1.1.13

0.089

-

-

441210

2.1.1.13

0.165

-

in 50 mM potassium phosphate (pH 7.2), 50 mM Tris-HCl (pH 7.2), 0.1 mM MgSO4, and 10 mM dithiothreitol, at 37°C

702050

2.1.1.13

2.4

-

-

441185

1.5.1.54

3 entries

1.5.7.1

2 entries

2.1.1.13

9 entries

2.1.1.14

0.000026

-

-

441322

2.1.1.258

0.002

-

in 50 mM MES, pH 5.1, at 25°C

717236

2.1.1.258

0.01

-

using hydroxocobalamin as cosubstrate, in 1 mM Tris-HCl (pH 7.6), at 25°C

718823

2.1.1.258

0.01

-

using [Co(I) corrinoid Fe-S protein] as cosubstrate, in 1 mM Tris-HCl (pH 7.6), at 25°C

718823

3.4.17.11

0.0129

-

-

647244

3.4.17.11

0.034

-

-

647247

6.3.2.17

0.054

-

pH 8.9, 37ºC, L1210 isoform

650131

6.3.2.17

0.064

-

pH 8.9, 37ºC, liver isoform

650131

2.1.1.258

3 entries

3.4.17.11

2 entries

6.3.2.17

2 entries

K_i Value (5 results)

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Show KI Value (5 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.5.1.3

0.15

-

-

392254

2.1.1.341

0.1

-

substrate vanillate, pH 8.0, 30°C

741347

2.1.1.341

0.17

-

substrate tetrahydrofolate, pH 8.0, 30°C

741347

2.1.1.341

2 entries

2.1.2.1

1.8

-

-

441407

2.1.2.9

0.003

-

-

485801

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.7.7.B24

0.0339

-

25°C, pH not specified in the publication

741002

References & Links

Literature References (110)

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Show Reference (110 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

1321

6609158

5,10-Methenyltetrahydrofolate synthetase. Purification and properties of the enzyme from rabbit liver

1984

Hopkins, S.; Schirch, V.

J. Biol. Chem.

259

5618-5622

1329

9250980

Human 5,10-methenyltetrahydrofolate synthetase

1997

Jolivet, J.

Methods Enzymol.

281

162-170

392149

4399897

Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine

1971

Kutzbach, C.; Stokstad, E.L.R.

Biochim. Biophys. Acta

250

459-477

392153

6352699

Methylenetetrahydrofolate reductase. Steady state and rapid reaction studies on the NADPH-methylenetetrahydrofolate, NADPH-menadione, and methyltetrahydrofolate-menadione oxidoreductase activities of the enzyme

1983

Vanoni, M.A.; Ballou, D.P.; Matthews, R.G.

J. Biol. Chem.

258

11510-11514

392155

3702701

Methylenetetrahydrofolate reductase from pig liver

1986

Matthews, R.G.

Methods Enzymol.

122

372-381

392157

2383427

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