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Squalene-2,3-oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol
1967
Willett, J.D.; Sharpless, K.B.; Lord, K.E.; van Tamelen, E.E.; Clayton, R.B.
J. Biol. Chem.
242
4182-4191
A soluble 2,3-oxidosqualene sterol cyclase
1967
Dean, P.D.G.; Ortiz de Montellano, P.R.; Bloch, K.; Corey, E.J.
J. Biol. Chem.
242
3014-3015
Some properties of the microsomal 2,3-oxidosqualene sterol cyclase
1969
Yamamoto, S.; Lin, K.; Bloch, K.
Proc. Natl. Acad. Sci. USA
63
110-117
Differential inhibition of fungal oxidosqualene cyclase by 6E and 6Z isomers of 2,3-epoxy-10-aza-10,11-dihydrosqualene
1993
Balliano, G.; Milla, P.; Ceruti, M.; Viola, F.; Carrano, L.; Cattel, L.
FEBS Lett.
320
203-206
Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae
1994
Shi, Z.; Buntel, C.J.; Griffin, J.H.
Proc. Natl. Acad. Sci. USA
91
7370-7374
The squalene epoxide-cyclase activity of human term placenta
1973
Tabacik, C.; Descomps, B.; Crastles de Paulet, A.
FEBS Lett.
34
238-242
Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase
1976
Saat, Y.A.; Bloch, K.E.
J. Biol. Chem.
251
5155-5160
Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10beta-trimethyl-trans-decal-3beta-ol
1979
Chang, T.Y.; Schiavoni, E.S.; McCrae, K.R.; Nelson, J.A.; Spencer, T.A.
J. Biol. Chem.
254
11258-11263
Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells
1984
Chen, H.W.; Leonard, D.A.
J. Biol. Chem.
259
8156-8162
N-[(1,5,9)-Trimethyl-decyl]-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol a novel potent inhibitor of 2,3-oxidosqualene cycloartenol and lanosterol cyclases
1986
Taton, M.; Benveniste, P.; Rahier, A.
Biochem. Biophys. Res. Commun.
138
764-770
Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase
1994
Corey, E.J.; Matsuda, S.P.T.; Bartel, B.
Proc. Natl. Acad. Sci. USA
91
2211-2215
Partial purification of 2,3-oxidosqualene-lanosterol cyclase from hog-liver. Evidence for functional thiol residue
1988
Duriatti, A.; Schuber, F.
Biochem. Biophys. Res. Commun.
151
1378-1385
Inhibition of sterol biosynthesis in Saccharomyces cerevisiae by N,N-diethylazasqualene and derivatives
1988
Balliano, G.; Viola, F.; Ceruti, M.; Cattel, L.
Biochim. Biophys. Acta
959
9-19
Non-specific lanosterol and hopanoid biosynthesis by a cell-free system from the bacterium Methylococcus capsulatus
1980
Rohmer, M.; Bouvier, P.; Ourisson, G.
Eur. J. Biochem.
112
557-560
-
Partial purification and characterization of oxidosqualene-lanosterol cyclase from baker's yeast
1991
Hoshino, T.; Williams, H.J.; Chung, Y.; Ian Scott, A.
Tetrahedron
47
5925-5932
-
Purification of the 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae
1991
Corey, E.J.; Matsuda, S.P.T.
J. Am. Chem. Soc.
113
8172-8174
Characterization and partial purification of squalene-2,3-oxide cyclase from Saccharomyces cerevisiae
1992
Balliano, G.; Viola, F.; Ceruti, M.; Cattel, L.
Arch. Biochem. Biophys.
293
122-129
Cloning and characterization of the 2,3-oxidosqualene cyclase-coding gene of Candida albicans
1990
Kelly, R.; Miller, S.M.; Lai, M.H.; Kirsch, D.R.
Gene
87
177-183
2,3,18,19-Dioxidosqualene stereoisomers: characterization and activity as inhibitors of purified pig liver 2,3-oxidosqualene-lanosterol cyclase
1996
Abad, J.L.; Guardiola, M.; Casas, J.; Sanchez-Baeza, F.; Messeguer, A.
J. Org. Chem.
61
7603-7607
2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors
1995
Cattel, L.; Ceruti, M.; Balliano, G.; Viola, F.; Grosa, G.; Rocco, F.; Brusa, P.
Lipids
30
235-246
Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives
1995
Viola, F.; Brusa, P.; Balliano, G.; Ceruti, M.; Boutaud, O.; Schuber, F.; Cattel, L.
Biochem. Pharmacol.
50
787-796
Inhibitors of 2,3-oxidosqualene lanosterol-cyclase as potential antifungal agents
1990
Jolidon, S.; Polak, A.M.; Guerry, P.; Hartman, P.G.
Biochem. Soc. Trans.
18
47-48
Purification and some properties of squalene 2,3-epoxide: lanosterol cyclase from rat liver
1991
Kusano, M.; Abe, I.; Sankawa, U.; Ebizuka, Y.
Chem. Pharm. Bull.
39
239-241
N-(1-Oxododecyl)-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase
1992
Wannamaker, M.W.; Waid, P.P.; van Sickle, W.A.; McCarthy, J.R.; Wilson, P.K.; Schatzman, G.L.; Moore, W.R.
J. Med. Chem.
35
3581-3583
Structural and stereoelectronic requirements for the inhibition of mammalian oxidosqualene cyclase by substituted isoquinoline derivatives
1996
Barth, M.M.; Binet, J.L.; Thomas, D.M.; de Fornel, D.C.; Samreth, S.; Schuber, F.J.; Renaut, P.P.
J. Med. Chem.
39
2302-2312
Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase
1997
Stach, D.; Zheng, Y.F.; Perez, A.L.; Oehlschlager, A.C.; Abe, I.; Prestwich, G.D.; Hartman, P.G.
J. Med. Chem.
40
201-209
9-Methylidine-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase
1998
Ceruti, M.; Rocco, F.; Viola, F.; Balliano, G.; Milla, P.; Arpicco, S.; Cattel, L.
J. Med. Chem.
41
540-554
Purification of 2,3-oxidosqualene cyclase from rat liver
1992
Moore, W.R.; Schatzman, G.L.
J. Biol. Chem.
267
22003-22006
Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase cDNA
1995
Abe, I.; Prestwich, G.D.
Proc. Natl. Acad. Sci. USA
92
9274-9278
2,3-Oxidosqualene cycloartenol cyclase from Ochromonas malhamensis
1969
Rees, H.H.; Goad, L.J.; Goodwin, T.W.
Biochim. Biophys. Acta
176
892-894
Properties of a 2,3-oxidosqualene-cycloartenol cyclase from Ochromonas malhamensis
1971
Beastall, G.H.; Rees, H.H.; Goodwin, T.W.
FEBS Lett.
18
175-178
2,3-Oxidosqualene cyclase and cycloartenol-S-adenosylmethionine methyltransferase activities in vivo the cotyledon and axis tissues of germinating pea seeds
1975
Fang, T.Y.; Baisted, D.J.
Biochem. J.
150
323-328
-
Cyclisation of 1-trans-1'-norsqualene-2,3-epoxide and 1-cis-1'-norsqualene-2,3-epoxide by a cell free system of corn embryos
1976
Cattel, L.; Anding, C.; Benveniste, P.
Phytochemistry
15
931-935
-
Inhibition of higher plant 2,3-oxidosqualene cyclase by 2-aza-2,3-dihydrosqualene and its derivatives
1983
Delprino, L.; Balliano, G.; Cattel, L.; Benveniste, P.; Bouvier, P.
J. Chem. Soc. Chem. Commun.
1983
381-382
Inhibition of 2,3-oxidosqualene cyclases
1992
Taton, M.; Benveniste, P.; Rahier, A.; Johnson, W.S.; Liu, H.; Sudhakar, A.R.
Biochemistry
31
7892-7898
Molecular cloning of pea cDNA encoding cycloartenol synthase and its functional expression in yeast
1997
Morita, M.; Shibuya, M.; Lee, M.S.; Sankawa, U.; Ebizuka, Y
Biol. Pharm. Bull.
20
770-775
-
Purification of 2,3-oxidosqualene:cycloartenol cyclase from pea seedlings
1988
Abe, I.; Ebizuka, Y.; Sankawa, U.
Chem. Pharm. Bull.
36
5031-5034
-
Purification and properties of squalene-2,3-epoxide cyclase from pea seedlings
1992
Abe, I.; Sankawa, U.; Ebizuka, Y.
Chem. Pharm. Bull.
40
1755-1760
Growth of Cucurbita maxima L. plants in the presence of the cycloartenol synthase inhibitor U18666A
1995
Fenner, G.P.; Raphiou, I.
Lipids
30
253-256
Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen
1993
Corey, E.J.; Matsuda, S.P.T.; Bartel, B.
Proc. Natl. Acad. Sci. USA
90
11628-11632
-
Purification of squalene-2,3-epoxide cyclase from cell suspension cultures of Rabdosia japonica Hara
1989
Abe, I.; Ebizuka, Y.; Seo, S.; Sankawa, U.
FEBS Lett.
249
100-104
-
Inhibition of sterol biosynthesis and accumulation of 2,3-oxidosqualene in bramble cell suspension cultures treated with 2-aza-2,3-dihydro-squalene and 2-aza-2,3-dihydrosqualene-N-oxide
1987
Schmitt, P.; Gonzales, R.; Benveniste, P.; Cerutti, M.; Cattel, L.
Phytochemistry
26
2709-2714
Solubilization and partial characterization of rat liver squalene epoxidase
1975
Ono, T.; Bloch, K.
J. Biol. Chem.
250
1571-1579
Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues
1977
Astruc, M.; Tabacik, C.; Descomps, B.; Crastes de Paulet, A.
Biochim. Biophys. Acta
487
204-211
-
Squalene oxidase: the elusive flavoenzyme of sterol biosynthesis
1991
Jordan, D.B.
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
-
865-868
Purification and partial characterization of squalene epoxidase from rat liver microsomes
1982
Ono, T.; Nakazono, K.; Kosaka, H.
Biochim. Biophys. Acta
709
84-90
Squalene epoxidase from rat liver microsomes
1985
Ono, T.; Imai, Y.
Methods Enzymol.
110
375-380
In vitro assay of squalene epoxidase of Saccharomyces cerevisiae
1987
M'Baya, B.; Karst, F.
Biochem. Biophys. Res. Commun.
147
556-564
Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes
1985
Ryder, N.S.; Dupont, M.C.
Biochem. J.
230
765-770
Properties of a particulate squalene epoxidase from Candida albicans
1984
Ryder, N.S.; Dupont, M.C.
Biochim. Biophys. Acta
794
466-471
Enzymic properties of squalene epoxidase from Saccharomyces cerevisiae
1993
Satoh, T.; Horie, M.; Watanabe, H.; Tsuchiya, Y.; Kamei, T.
Biol. Pharm. Bull.
16
349-352
Purification and characterization of recombinant squalene epoxidase
1995
Nagumo, A.; Kamei, T.; Sakakibara, J.; Ono, T.
J. Lipid Res.
36
1489-1497
Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase
2000
Laden, B.P.; Tang, Y.; Porter, T.D.
Arch. Biochem. Biophys.
374
381-388
Purification, tandem mass characterization, and inhibition studies of oxidosqualene-lanosterol cyclase enzyme from bovine liver
2004
Wu, T.K.; Huang, C.Y.; Ko, C.Y.; Chang, C.H.; Chen, Y.J.; Liao, H.K.
Arch. Biochem. Biophys.
421
42-53
The monotopic membrane protein human oxidosqualene cyclase is active as monomer
2004
Ruf, A.; Muller, F.; D'Arcy, B.; Stihle, M.; Kusznir, E.; Handschin, C.; Morand, O.H.; Thoma, R.
Biochem. Biophys. Res. Commun.
315
247-254
Cloning and characterization of the Dictyostelium discoideum cycloartenol synthase cDNA
2000
Godzina, S.M.; Lovato, M.A.; Meyer, M.M.; Foster, K.A.; Wilson, W.K.; Gu, W.; de Hostos, E.L.; Matsuda, S.P.
Lipids
35
249-255
Steric bulk at cycloartenol synthase position 481 influences cyclization and deprotonation
2000
Matsuda, S.P.; Darr, L.B.; Hart, E.A.; Herrera, J.B.; McCann, K.E.; Meyer, M.M.; Pang, J.; Schepmann, H.G.
Org. Lett.
2
2261-2263
Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis
2002
Segura, M.J.; Lodeiro, S.; Meyer, M.M.; Patel, A.J.; Matsuda, S.P.
Org. Lett.
4
4459-4462
Properties of liver microsomal cholesterol 5,6-oxide hydrolase
1985
Nashed, N.T.; Michaud, D.P.; Levin, W.; Jerina, D.M.
Arch. Biochem. Biophys.
241
149-162
Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra
2004
Hayashi, H.; Huang, P.; Takada, S.; Obinata, M.; Inoue, K.; Shibuya, M.; Ebizuka, Y.
Biol. Pharm. Bull.
27
1086-1092
Inhibition of human lanosterol synthase by the constituents of Colocasia esculenta (taro)
2005
Sakano, Y.; Mutsuga, M.; Tanaka, R.; Suganuma, H.; Inakuma, T.; Toyoda, M.; Goda, Y.; Shibuya, M.; Ebizuka, Y.
Biol. Pharm. Bull.
28
299-304
Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase
2005
Tanaka, R.; Sakano, Y.; Nagatsu, A.; Shibuya, M.; Ebizuka, Y.; Goda, Y.
Bioorg. Med. Chem. Lett.
15
159-162
-
Cloning and molecular analysis of cDNA encoding cycloartenol synthase from Centella asiatica (L.) urban
2005
Kim, O.T.; Kim, M.Y.; Hwang, S.J.; Ahn, J.C.; Hwang, B.
Biotechnol. Bioprocess Eng.
10
16-22
Oxidosqualene cyclase second-sphere residues profoundly influence the product profile
2004
Lodeiro, S.; Segura, M.J.R.; Stahl, M.; Schulz-Gasch, T.; Matsuda, S.P.T.
ChemBioChem
5
1581-1585
Enzymatic formation of multiple triterpenes by mutation of tyrosine 510 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae
2004
Wu, T.K.; Chang, C.H.
ChemBioChem
5
1712-1715
Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis approach
2005
Oliaro-Bosso, S.; Schulz-Gasch, T.; Balliano, G.; Viola, F.
ChemBioChem
6
2221-2228
Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase
2005
Lodeiro, S.; Schulz-Gasch, T.; Matsuda, S.P.T.
J. Am. Chem. Soc.
127
14132-14133
Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat
2006
Mori, M.; Li, G.; Abe, I.; Nakayama, J.; Guo, Z.; Sawashita, J.; Ugawa, T.; Nishizono, S.; Serikawa, T.; Higuchi, K.; Shumiya, S.
J. Clin. Invest.
116
395-404
Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, and Pneumocystis carinii
2004
Oliaro-Bosso, S.; Viola, F.; Matsuda, S.; Cravotto, G.; Tagliapietra, S.; Balliano, G.
Lipids
39
1007-1012
Synthesis and biological activity of new iodoacetamide derivatives on mutants of squalene-hopene cyclase
2005
Ceruti, M.; Balliano, G.; Rocco, F.; Lenhart, A.; Schulz, G.E.; Castelli, F.; Milla, P.
Lipids
40
729-735
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase
2004
Thoma, R.; Schulz-Gasch, T.; D'Arcy, B.; Benz, J.; Aebi, J.; Dehmlow, H.; Hennig, M.; Stihle, M.; Ruf, A.
Nature
432
118-122
A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants
2006
Lodeiro, S.; Wilson, W.K.; Shan, H.; Matsuda, S.P.
Org. Lett.
8
439-442
Epoxide hydrolases: their roles and interactions with lipid metabolism
2005
Newman, J.W.; Morisseau, C.; Hammock, B.D.
Prog. Lipid Res.
44
1-51
Lanosterol biosynthesis in plants
2006
Kolesnikova, M.D.; Xiong, Q.; Lodeiro, S.; Hua, L.; Matsuda, S.P.
Arch. Biochem. Biophys.
447
87-95
Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis
2006
Guhling, O.; Hobl, B.; Yeats, T.; Jetter, R.
Arch. Biochem. Biophys.
448
60-72
Cloning and functional expression of cycloartenol synthases from mangrove species Rhizophora stylosa Griff. and Kandelia candel (L.) Druce
2007
Basyuni, M.; Oku, H.; Tsujimoto, E.; Baba, S.
Biosci. Biotechnol. Biochem.
71
1788-1792
Sterol biosynthesis by a prokaryote: first in vitro identification of the genes encoding squalene epoxidase and lanosterol synthase from Methylococcus capsulatus
2007
Nakano, C.; Motegi, A.; Sato, T.; Onodera, M.; Hoshino, T.
Biosci. Biotechnol. Biochem.
71
2543-2550
Site-saturated mutagenesis of histidine 234 of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions
2006
Wu, T.K.; Liu, Y.T.; Chang, C.H.; Yu, M.T.; Wang, H.J.
J. Am. Chem. Soc.
128
6414-6419
Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis
2007
Lamb, D.C.; Jackson, C.J.; Warrilow, A.G.; Manning, N.J.; Kelly, D.E.; Kelly, S.L.
Mol. Biol. Evol.
24
1714-1721
Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions
2006
Wu, T.K.; Yu, M.T.; Liu, Y.T.; Chang, C.H.; Wang, H.J.; Diau, E.W.
Org. Lett.
8
1319-1322
Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-Ring cyclization and deprotonation reactions
2006
Wu, T.K.; Liu, Y.T.; Chiu, F.H.; Chang, C.H.
Org. Lett.
8
4691-4694
Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes
2006
Sawai, S.; Akashi, T.; Sakurai, N.; Suzuki, H.; Shibata, D.; Ayabe, S.; Aoki, T.
Plant Cell Physiol.
47
673-677
-
Functional and structural analysis of genes encoding oxidosqualene cyclases of Lotus japonicus
2006
Sawai, S.; Shindo, T.; Sato, S.; Kaneko, T.; Tabata, S.; Ayabe, S.; Aoki, T.
Plant Sci.
170
247-257
In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes
1997
Kushiro, T.; Ohno, Y.; Shibuya, M.; Ebizuka, Y.
Biol. Pharm. Bull.
20
292-294
Cloning and characterization of a cDNA encoding beta-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice
2001
Hayashi, H.; Huang, P.; Kirakosyan, A.; Inoue, K.; Hiraoka, N.; Ikeshiro, Y.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.
Biol. Pharm. Bull.
24
912-916
Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants
2003
Zhang, H.; Shibuya, M.; Yokota, S.; Ebizuka, Y.
Biol. Pharm. Bull.
26
642-650
beta-Amyrin synthase - cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants
1998
Kushiro, T.; Shibuya, M.; Ebizuka, Y.
Eur. J. Biochem.
256
238-244
Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases
1999
Shibuya, M.; Zhang, H.; Endo, A.; Shishikura, K.; Kushiro, T.; Ebizuka, Y.
Eur. J. Biochem.
266
302-307
Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase
2000
Morita, M.; Shibuya, M.; Kushiro, T.; Masuda, K.; Ebizuka, Y.
Eur. J. Biochem.
267
3453-3460
Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae
2007
Basyuni, M.; Oku, H.; Tsujimoto, E.; Kinjo, K.; Baba, S.; Takara, K.
FEBS J.
274
5028-5042
Engineering triterpene production in Saccharomyces cerevisiae-beta-amyrin synthase from Artemisia annua
2008
Kirby, J.; Romanini, D.W.; Paradise, E.M.; Keasling, J.D.
FEBS J.
275
1852-1859
Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng
2006
Tansakul, P.; Shibuya, M.; Kushiro, T.; Ebizuka, Y.
FEBS Lett.
580
5143-5149
-
Mutational studies on triterpene synthases: engineering lupeol synthase into beta-amyrin synthase
2000
Kushiro, T.; Shibuya, M.; Masuda, K.; Ebizuka, Y.
J. Am. Chem. Soc.
122
6816-6824
Mechanism and stereochemistry of enzymatic cyclization of 24,30-bisnor-2,3-oxidosqualene by recombinant beta-amyrin synthase
2004
Abe, I.; Sakano, Y.; Sodeyama, M.; Tanaka, H.; Noguchi, H.; Shibuya, M.; Ebizuka, Y.
J. Am. Chem. Soc.
126
6880-6881
Origin of structural diversity in natural triterpenes: direct synthesis of seco-triterpene skeletons by oxidosqualene cyclase
2007
Shibuya, M.; Xiang, T.; Katsube, Y.; Otsuka, M.; Zhang, H.; Ebizuka, Y.
J. Am. Chem. Soc.
129
1450-1455
Structure and reactivity of the dammarenyl cation: configurational transmission in triterpene synthesis
2005
Xiong, Q.; Rocco, F.; Wilson, W.K.; Xu, R.; Ceruti, M.; Matsuda, S.P.
J. Org. Chem.
70
5362-5375
Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol
2000
Segura, M.J.; Meyer, M.M.; Matsuda, S.P.
Org. Lett.
2
2257-2259
Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization
2006
Kushiro, T.; Hoshino, M.; Tsutsumi, T.; Kawai, K.i.; Shiro, M.; Shibuya, M.; Ebizuka, Y.
Org. Lett.
8
5589-5592
-
Inhibition of higher plant 2,3-oxidosqualene cyclases by nitrogen-containing oxidosqualene analogs
1996
Taton, M.; Ceruti, M.; Cattel, L.; Rahier, A.
Phytochemistry
43
75-81
Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene
1998
Herrera, J.B.; Bartel, B.; Wilson, W.K.; Matsuda, S.P.
Phytochemistry
49
1905-1911
Cloning and characterization of a cDNA encoding beta-amyrin synthase from petroleum plant Euphorbia tirucalli L.
2005
Kajikawa, M.; Yamato, K.T.; Fukuzawa, H.; Sakai, Y.; Uchida, H.; Ohyama, K.
Phytochemistry
66
1759-1766
Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng
2006
Han, J.Y.; Kwon, Y.S.; Yang, D.C.; Jung, Y.R.; Choi, Y.E.
Plant Cell Physiol.
47
1653-1662
Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana
2001
Husselstein-Muller, T.; Schaller, H.; Benveniste, P.
Plant Mol. Biol.
45
75-92
Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus
2003
Iturbe-Ormaetxe, I.; Haralampidis, K.; Papadopoulou, K.; Osbourn, A.E.
Plant Mol. Biol.
51
731-743
Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase
2007
Meesapyodsuk, D.; Balsevich, J.; Reed, D.W.; Covello, P.S.
Plant Physiol.
143
959-969
-
Cryptic regiospecificity in deprotonation step of triterpene biosynthesis catalyzed by new members of lupeol synthase
1999
Kushiro, T.; Shibuya, M.; Ebizuka, Y.
Tetrahedron Lett.
40
5553-5556
-
A novel multifunctional triterpene synthase from Arabidopsis thaliana
2000
Kushiro, T.; Shibuya, M.; Masuda, K.; Ebizuka, Y.
Tetrahedron Lett.
41
7705-7710
Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase
2007
Abe, I.; Abe, T.; Lou, W.; Masuoka, T.; Noguchi, H.
Biochem. Biophys. Res. Commun.
352
259-263
Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae
2008
Teske, B.; Taramino, S.; Bhuiyan, M.S.; Kumaraswami, N.S.; Randall, S.K.; Barbuch, R.; Eckstein, J.; Balliano, G.; Bard, M.
Biochim. Biophys. Acta
1781
359-366
Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity
2008
Fouchet, M.H.; Donche, F.; Martin, C.; Bouillot, A.; Junot, C.; Boullay, A.B.; Potvain, F.; Magny, S.D.; Coste, H.; Walker, M.; Issandou, M.; Dodic, N.
Bioorg. Med. Chem.
16
6218-6232
Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the proteins structure-function-reaction mechanism relationships
2008
Wu, T.K.; Chang, C.H.; Liu, Y.T.; Wang, T.T.
Chem. Rec.
8
302-325
Squalene cyclase and oxidosqualene cyclase from a fern
2008
Shinozaki, J.; Shibuya, M.; Masuda, K.; Ebizuka, Y.
FEBS Lett.
582
310-318
Suppression of 2,3-oxidosqualene cyclase by high-fat diet contributes to liver X receptor-alpha -mediated improvement of hepatic lipid profile
2009
Dang, H.; Liu, Y.; Pang, W.; Wang, N.; Shyy, J.Y.; Zhu, Y.
J. Biol. Chem.
284
6218-6226
Protein plasticity: a single amino acid substitution in the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase generates protosta-13(17),24-dien-3beta-ol, a rearrangement product
2008
Wu, T.K.; Wen, H.Y.; Chang, C.H.; Liu, Y.T.
Org. Lett.
10
2529-2532
Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions
2008
Wu, T.K.; Wang, T.T.; Chang, C.H.; Liu, Y.T.; Shie, W.S.
Org. Lett.
10
4959-4962
Enhanced triterpene saponin biosynthesis and root nodulation in transgenic barrel medic (Medicago truncatula Gaertn.) expressing a novel beta-amyrin synthase (AsOXA1) gene
2009
Confalonieri, M.; Cammareri, M.; Biazzi, E.; Pecchia, P.; Fevereiro, M.P.; Balestrazzi, A.; Tava, A.; Conicella, C.
Plant Biotechnol. J.
7
172-182
Identification of a product specific beta-amyrin synthase from Arabidopsis thaliana
2009
Shibuya, M.; Katsube, Y.; Otsuka, M.; Zhang, H.; Tansakul, P.; Xiang, T.; Ebizuka, Y.
Plant Physiol. Biochem.
47
26-30
-
Molecular characterization of beta-amyrin synthase from Aster sedifolius L. and triterpenoid saponin analysis
2008
Cammareri, M.; Consiglio, M.F.; Pecchia, P.; Corea, G.; Lanzotti, V.; Ibeas, J.I.; Tava, A.; Conicella, C.
Plant Sci.
175
255-261
Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis
2008
Babiychuk, E.; Bouvier-Nave, P.; Compagnon, V.; Suzuki, M.; Muranaka, T.; Van Montagu, M.; Kushnir, S.; Schaller, H.
Proc. Natl. Acad. Sci. USA
105
3163-3168
Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis
2009
Ohyama, K.; Suzuki, M.; Kikuchi, J.; Saito, K.; Muranaka, T.
Proc. Natl. Acad. Sci. USA
106
725-730
-
Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of Panax notoginseng treated with chemically synthesized 2-hydroxyethyl jasmonate
2008
Hu, F.; Zhong, J.
Process Biochem.
43
113-118
Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia
2009
Seiki, S.; Frishman, W.H.
Cardiol. Rev.
17
70-76
Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical
2008
Morisseau, C.; Hammock, B.D.
Pest Manag. Sci.
64
594-609
Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast
2010
Taramino, S.; Valachovic, M.; Oliaro-Bosso, S.; Viola, F.; Teske, B.; Bard, M.; Balliano, G.
Biochim. Biophys. Acta
1801
156-162
Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition
2009
Duniec-Dmuchowski, Z.; Fang, H.L.; Strom, S.C.; Ellis, E.; Runge-Morris, M.; Kocarek, T.A.
Drug Metab. Dispos.
37
900-908
Functional characterization and localization of Pneumocystis carinii lanosterol synthase
2010
Joffrion, T.M.; Collins, M.S.; Sesterhenn, T.; Cushion, M.T.
Eukaryot. Cell
9
107-115
Alteration of the substrates prefolded conformation and cyclization stereochemistry of oxidosqualene-lanosterol cyclase of Saccharomyces cerevisiae by substitution at phenylalanine 699
2010
Wu, T.K.; Chang, C.H.; Wen, H.Y.; Liu, Y.T.; Li, W.H.; Wang, T.T.; Shie, W.S.
Org. Lett.
12
500-503
-
Upregulation of ginsenoside and gene expression related to triterpene biosynthesis in ginseng hairy root cultures elicited by methyl jasmonate
2009
Kim, O.; Bang, K.; Kim, Y.; Hyun, D.; Kim, M.; Cha, S.
Plant Cell Tissue Organ Cult.
98
25-33
-
Antisense suppression of cycloartenol synthase results in elevated ginsenoside levels in Panax ginseng hairy roots
2009
Liang, Y.; Zhao, S.; Zhang, X.
Plant Mol. Biol. Rep.
27
298-304
Characterization of a dammarenediol synthase in Centella asiatica (L.) Urban
2009
Kim, O.T.; Lee, J.W.; Bang, K.H.; Kim, Y.C.; Hyun, D.Y.; Cha, S.W.; Choi, Y.E.; Jin, M.L.; Hwang, B.
Plant Physiol. Biochem.
47
998-1002
Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts
2010
Taramino, S.; Teske, B.; Oliaro-Bosso, S.; Bard, M.; Balliano, G.
Biochim. Biophys. Acta
1801
1232-1237
An unusual plant triterpene synthase with predominant alpha-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica
2011
Brendolise, C.; Yauk, Y.K.; Eberhard, E.D.; Wang, M.; Chagne, D.; Andre, C.; Greenwood, D.R.; Beuning, L.L.
FEBS J.
278
2485-2499
Arabidopsis camelliol C synthase evolved from enzymes that make pentacycles
2007
Kolesnikova, M.D.; Wilson, W.K.; Lynch, D.A.; Obermeyer, A.C.; Matsuda, S.P.
Org. Lett.
9
5223-5226
-
Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol
2000
Khenkin, A.; Neumann, R.
Angew. Chem.
39
4090-4092
An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by grob fragmentation
2006
Xiong, Q.; Wilson, W.; Matsuda, S.
Angew. Chem.
45
1285-1288
Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase
2010
Kimura, M.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.; Abe, I.
Biochem. Biophys. Res. Commun.
391
899-902
Molecular cloning, characterization, and differential expression of a lanosterol synthase gene from Ganoderma lucidum
2010
Shang, C.H.; Shi, L.; Ren, A.; Qin, L.; Zhao, M.W.
Biosci. Biotechnol. Biochem.
74
974-978
Histidine residue at position 234 of oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae simultaneously influences cyclization, rearrangement, and deprotonation reactions
2005
Wu, T.; Liu, Y.; Chang, C.
ChemBioChem
6
1177-1181
Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid
2001
Hayashi, H.; Huang, P.; Inoue, K.; Hiraoka, N.; Ikeshiro, Y.; Yazaki, K.; Tanaka, S.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.
Eur. J. Biochem.
268
6311-6317
Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus
2011
Sawai, S.; Uchiyama, H.; Mizuno, S.; Aoki, T.; Akashi, T.; Ayabe, S.; Takahashi, T.
FEBS Lett.
585
1031-1036
-
Directed evolution to investigate steric control of enzymatic oxidosqualene cyclization. An isoleucine-to-valine mutation in cycloartenol synthase allows lanosterol and parkeol biosynthesis
1999
Hart, E.; Hua, L.; Darr, L.; Wilson, W.; Pang, J.; Matsuda, S.
J. Am. Chem. Soc.
121
9887-9888
Genome mining to identify new plant triterpenoids
2004
Fazio, G.C.; Xu, R.; Matsuda, S.P.
J. Am. Chem. Soc.
126
5678-5679
Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids
2010
Wang, Z.; Yeats, T.; Han, H.; Jetter, R.
J. Biol. Chem.
285
29703-29712
Production of plant bioactive triterpenoid saponins: elicitation strategies and target genes to improve yields
2010
Yendo, A.C.; de Costa, F.; Gosmann, G.; Fett-Neto, A.G.
Mol. Biotechnol.
46
94-104
Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterols C/D-ring cyclization and 17alpha/beta-exocyclic side chain stereochemistry
2011
Wu, T.K.; Chang, Y.C.; Liu, Y.T.; Chang, C.H.; Wen, H.Y.; Li, W.H.; Shie, W.S.
Org. Biomol. Chem.
9
1092-1097
Biosynthesis of baccharis oxide, a triterpene with a 3, 10-oxide bridge in the A-ring
2008
Shibuya, M.; Sagara, A.; Saitoh, A.; Kushiro, T.; Ebizuka, Y.
Org. Lett.
10
5071-5074
Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus
2009
Lodeiro, S.; Xiong, Q.; Wilson, W.; Ivanova, Y.; Smith, M.; May, G.; Matsuda, S.
Org. Lett.
11
1241-1244
Product profile of PEN3: the last unexamined oxidosqualene cyclase in Arabidopsis thaliana
2009
Morlacchi, P.; Wilson, W.K.; Xiong, Q.; Bhaduri, A.; Sttivend, D.; Kolesnikova, M.D.; Matsuda, S.P.
Org. Lett.
11
2627-2630
Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases
2011
Ito, R.; Mori, K.; Hashimoto, I.; Nakano, C.; Sato, T.; Hoshino, T.
Org. Lett.
13
2678-2681
A new triterpene synthase from Arabidopsis thaliana produces a tricyclic triterpene with two hydroxyl groups
2006
Xiang, T.; Shibuya, M.; Katsube, Y.; Tsutsumi, T.; Otsuka, M.; Zhang, H.; Masuda, K.; Ebizuka, Y.
Org. Lett.
8
2835-2838
Manipulation of saponin biosynthesis by RNA interference-mediated silencing of beta-amyrin synthase gene expression in soybean
2011
Takagi, K.; Nishizawa, K.; Hirose, A.; Kita, A.; Ishimoto, M.
Plant Cell Rep.
30
1835-1846
Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids
2011
Wang, Z.; Guhling, O.; Yao, R.; Li, F.; Yeats, T.H.; Rose, J.K.; Jetter, R.
Plant Physiol.
155
540-552
-
Assessment of squalene synthase and beta-amyrin synthase gene expression in licorice roots treated with methyl jasmonate and salicylic acid using real-time qPCR
2010
Shabani, L.; Ehsanpour, A.; Esmaeili, A.
Russ. J. Plant Physiol.
57
480-484
-
Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol biosynthesis
2004
Shibuya, M.; Adachi, S.; Ebizuka, Y.
Tetrahedron
60
6995-7003
An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis
2007
Lodeiro, S.; Xiong, Q.; Wilson, W.K.; Kolesnikova, M.D.; Onak, C.S.; Matsuda, S.P.
J. Am. Chem. Soc.
129
11213-11222
The cysteine 703 to isoleucine or histidine mutation of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae generates an iridal-type triterpenoid
2012
Chang, C.H.; Chen, Y.C.; Tseng, S.W.; Liu, Y.T.; Wen, H.Y.; Li, W.H.; Huang, C.Y.; Ko, C.Y.; Wang, T.T.; Wu, T.K.
Biochimie
94
2376-2381
Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring
2012
Hoshino, T.; Chiba, A.; Abe, N.
Chemistry
18
13108-13116
Catalytic mechanism and product specificity of oxidosqualene-lanosterol cyclase: a QM/MM study
2012
Tian, B.X.; Eriksson, L.A.
J. Phys. Chem. B
116
13857-13862
Protein engineering of oxidosqualene-lanosterol cyclase into triterpene monocyclase
2013
Chang, C.H.; Wen, H.Y.; Shie, W.S.; Lu, C.T.; Li, M.E.; Liu, Y.T.; Li, W.H.; Wu, T.K.
Org. Biomol. Chem.
11
4214-4219
Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase
2012
Liu, Y.T.; Hu, T.C.; Chang, C.H.; Shie, W.S.; Wu, T.K.
Org. Lett.
14
5222-5225
Molecular cloning, expression, purification, and functional characterization of dammarenediol synthase from Panax ginseng
2013
Hu, W.; Liu, N.; Tian, Y.; Zhang, L.
BioMed Res. Int.
2013
285740
Effect of cation-pi interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of beta-amyrin synthase from Euphorbia tirucalli L
2013
Ito, R.; Hashimoto, I.; Masukawa, Y.; Hoshino, T.
Chemistry
19
17150-17158
Purification, kinetics, inhibitors and CD for recombinant beta-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases
2013
Ito, R.; Masukawa, Y.; Hoshino, T.
FEBS J.
280
1267-1280
The isolation and characterization of dammarenediol synthase gene from Panax quinquefolius and its heterologous co-expression with cytochrome P450 gene PqD12H in yeast
2014
Wang, L.; Zhao, S.J.; Cao, H.J.; Sun, Y.
Funct. Integr. Genomics
14
545-557
Heterologous expression of dammarenediol synthase gene in an engineered Saccharomyces cerevisiae
2012
Liang, Y.; Zhao, S.; Xu, L.; Zhang, X.
Lett. Appl. Microbiol.
55
323-329
Dammarenediol-II production confers TMV tolerance in transgenic tobacco expressing Panax ginseng dammarenediol-II synthase
2012
Lee, M.H.; Han, J.Y.; Kim, H.J.; Kim, Y.S.; Huh, G.H.; Choi, Y.E.
Plant Cell Physiol.
53
173-182
Production of dammarenediol-II triterpene in a cell suspension culture of transgenic tobacco
2014
Han, J.Y.; Wang, H.Y.; Choi, Y.E.
Plant Cell Rep.
33
225-233
beta-Amyrin synthase (EsBAS) and beta-amyrin 28-oxidase (CYP716A244) in oleanane-type triterpene saponin biosynthesis in Eleutherococcus senticosus
2017
Jo, H.J.; Han, J.Y.; Hwang, H.S.; Choi, Y.E.
Phytochemistry
135
53-63
beta-Amyrin synthase (EsBAS) and beta-amyrin 28-oxidase (CYP716A244) in oleanane-type triterpene saponin biosynthesis in Eleutherococcus senticosus
2017
Jo, H.J.; Han, J.Y.; Hwang, H.S.; Choi, Y.E.
Phytochemistry
135
53-63
Functional characterization of cucurbitadienol synthase and triterpene glycosyltransferase involved in biosynthesis of mogrosides from Siraitia grosvenorii
2015
Dai, L.; Liu, C.; Zhu, Y.; Zhang, J.; Men, Y.; Zeng, Y.; Sun, Y.
Plant Cell Physiol.
56
1172-1182
Functional characterization of cucurbitadienol synthase and triterpene glycosyltransferase involved in biosynthesis of mogrosides from Siraitia grosvenorii
2015
Dai, L.; Liu, C.; Zhu, Y.; Zhang, J.; Men, Y.; Zeng, Y.; Sun, Y.
Plant Cell Physiol.
56
1172-1182
Oxidation of cucurbitadienol catalyzed by CYP87D18 in the biosynthesis of mogrosides from Siraitia grosvenorii
2016
Zhang, J.; Dai, L.; Yang, J.; Liu, C.; Men, Y.; Zeng, Y.; Cai, Y.; Zhu, Y.; Sun, Y.
Plant Cell Physiol.
57
1000-1007
Oxidation of cucurbitadienol catalyzed by CYP87D18 in the biosynthesis of mogrosides from Siraitia grosvenorii
2016
Zhang, J.; Dai, L.; Yang, J.; Liu, C.; Men, Y.; Zeng, Y.; Cai, Y.; Zhu, Y.; Sun, Y.
Plant Cell Physiol.
57
1000-1007
Cloning and characterization of squalene synthase and cycloartenol synthase from Siraitia grosvenorii
2017
Zhao, H.; Tang, Q.; Mo, C.; Bai, L.; Tu, D.; Ma, X.
Acta Pharm. Sin. B
7
215-222
Cloning and characterization of squalene synthase and cycloartenol synthase from Siraitia grosvenorii
2017
Zhao, H.; Tang, Q.; Mo, C.; Bai, L.; Tu, D.; Ma, X.
Acta Pharm. Sin. B
7
215-222
Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli
2016
Li, D.; Zhang, Q.; Zhou, Z.; Zhao, F.; Lu, W.
Biotechnol. Lett.
38
603-609
Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli
2016
Li, D.; Zhang, Q.; Zhou, Z.; Zhao, F.; Lu, W.
Biotechnol. Lett.
38
603-609
Euphorbia tirucalli beta-amyrin synthase critical roles of steric sizes at Val483 and Met729 and the CH-Pi interaction between Val483 and Trp534 for catalytic action
2017
Hoshino, T.; Nakagawa, K.; Aiba, Y.; Itoh, D.; Nakada, C.; Masukawa, Y.
ChemBioChem
18
2145-2155
Alicyclobacillus acidocaldarius squalene-hopene cyclase the critical role of steric bulk at Ala306 and the first enzymatic synthesis of epoxydammarane from 2,3-oxidosqualene
2018
Ideno, N.; Umeyama, S.; Watanabe, T.; Nakajima, M.; Sato, T.; Hoshino, T.
ChemBioChem
19
1873-1886
Alicyclobacillus acidocaldarius squalene-hopene cyclase the critical role of steric bulk at Ala306 and the first enzymatic synthesis of epoxydammarane from 2,3-oxidosqualene
2018
Ideno, N.; Umeyama, S.; Watanabe, T.; Nakajima, M.; Sato, T.; Hoshino, T.
ChemBioChem
19
1873-1886
-
Cloning, prokaryotic expression, and functional identification of beta-amyrin synthase cDNA of Psammosilene tunicoides
2014
Liu, J.; Xie, H.; Chen, H.; Qian, Z.
Chin. Tradit. Herbal Drugs
45
1456-1460
beta-Amyrin synthase from Conyza blinii expressed in Saccharomyces cerevisiae
2017
Sun, R.; Liu, S.; Tang, Z.Z.; Zheng, T.R.; Wang, T.; Chen, H.; Li, C.L.; Wu, Q.
FEBS open bio
7
1575-1585
-
Functional characterization of the beta-amyrin synthase gene involved in platycoside biosynthesis in Platycodon grandiflorum
2017
Um, Y.; Jin, M.; Lee, D.; Kim, C.; Hong, C.; Lee, Y.; Kim, O.
Hortic. Environ. Biotechnol.
58
613-619
Two cycloartenol synthases for phytosterol biosynthesis in Polygala tenuifolia willd
2017
Jin, M.; Lee, W.; Kim, O.
Int. J. Mol. Sci.
18
2426-2437
Two cycloartenol synthases for phytosterol biosynthesis in Polygala tenuifolia willd
2017
Jin, M.; Lee, W.; Kim, O.
Int. J. Mol. Sci.
18
2426-2437
-
Molecular simulation and catalytic active sites identification of dammarenediol-II synthase
2017
Liu, T.; Zhang, X.; Zhao, F.; Lu, W.
J. Beijing Inst. Technol.
26
563-570
Metabolic engineering of Pichia pastoris for the production of dammarenediol-II
2015
Liu, X.B.; Liu, M.; Tao, X.Y.; Zhang, Z.X.; Wang, F.Q.; Wei, D.Z.
J. Biotechnol.
216
47-55
Metabolic engineering of Pichia pastoris for the production of dammarenediol-II
2015
Liu, X.B.; Liu, M.; Tao, X.Y.; Zhang, Z.X.; Wang, F.Q.; Wei, D.Z.
J. Biotechnol.
216
47-55
Inhibition of cycloartenol synthase (CAS) function in tobacco BY-2 cell suspensions a proteomic analysis
2015
Gas-Pascual, E.; Simonovik, B.; Heintz, D.; Bergdoll, M.; Schaller, H.; Bach, T.J.
Lipids
50
773-784
Inhibition of cycloartenol synthase (CAS) function in tobacco BY-2 cell suspensions a proteomic analysis
2015
Gas-Pascual, E.; Simonovik, B.; Heintz, D.; Bergdoll, M.; Schaller, H.; Bach, T.J.
Lipids
50
773-784
Strengthening triterpene saponins biosynthesis by over-expression of farnesyl pyrophosphate synthase gene and RNA interference of cycloartenol synthase gene in Panax notoginseng cells
2017
Yang, Y.; Ge, F.; Sun, Y.; Liu, D.; Chen, C.
Molecules
22
581-592
Strengthening triterpene saponins biosynthesis by over-expression of farnesyl pyrophosphate synthase gene and RNA interference of cycloartenol synthase gene in Panax notoginseng cells
2017
Yang, Y.; Ge, F.; Sun, Y.; Liu, D.; Chen, C.
Molecules
22
581-592
Friedelin in Maytenus ilicifolia is produced by friedelin synthase isoforms
2018
Alves, T.B.; Souza-Moreira, T.M.; Valentini, S.R.; Zanelli, C.F.; Furlan, M.
Molecules
23
700-711
Friedelin in Maytenus ilicifolia is produced by friedelin synthase isoforms
2018
Alves, T.B.; Souza-Moreira, T.M.; Valentini, S.R.; Zanelli, C.F.; Furlan, M.
Molecules
23
700-711
Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids
2016
Andre, C.; Legay, S.; Deleruelle, A.; Nieuwenhuizen, N.; Punter, M.; Brendolise, C.; Cooney, J.; Lateur, M.; Hausman, J.; Larondelle, Y.; Laing, W.
New Phytol.
211
1279-1294
Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids
2016
Andre, C.; Legay, S.; Deleruelle, A.; Nieuwenhuizen, N.; Punter, M.; Brendolise, C.; Cooney, J.; Lateur, M.; Hausman, J.; Larondelle, Y.; Laing, W.
New Phytol.
211
1279-1294
Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species
2018
Xue, Z.; Tan, Z.; Huang, A.; Zhou, Y.; Sun, J.; Wang, X.; Thimmappa, R.B.; Stephenson, M.J.; Osbourn, A.; Qi, X.
New Phytol.
218
1076-1088
Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species
2018
Xue, Z.; Tan, Z.; Huang, A.; Zhou, Y.; Sun, J.; Wang, X.; Thimmappa, R.B.; Stephenson, M.J.; Osbourn, A.; Qi, X.
New Phytol.
218
1076-1088
beta-Amyrin synthase from Euphorbia tirucalli. Steric bulk, not the Pi-electrons of Phe, at position 474 has a key role in affording the correct folding of the substrate to complete the normal polycyclization cascade
2014
Ito, R.; Masukawa, Y.; Nakada, C.; Amari, K.; Nakano, C.; Hoshino, T.
Org. Biomol. Chem.
12
3836-3846
beta-Amyrin synthase from Euphorbia tirucalli. Steric bulk, not the Pi-electrons of Phe, at position 474 has a key role in affording the correct folding of the substrate to complete the normal polycyclization cascade
2014
Ito, R.; Masukawa, Y.; Nakada, C.; Amari, K.; Nakano, C.; Hoshino, T.
Org. Biomol. Chem.
12
3836-3846
beta-Amyrin synthase from Euphorbia tirucalli L. functional analyses of the highly conserved aromatic residues Phe413, Tyr259 and Trp257 disclose the importance of the appropriate steric bulk, and cation-Pi and CH-Pi interactions for the efficient catalytic
2017
Ito, R.; Nakada, C.; Hoshino, T.
Org. Biomol. Chem.
15
177-188
Astertarone A synthase from chinese cabbage does not produce the C4-epimer mechanistic insights
2018
Jin, J.; Moore, M.K.; Wilson, W.K.; Matsuda, S.P.T.
Org. Lett.
20
1802-1805
Astertarone A synthase from chinese cabbage does not produce the C4-epimer mechanistic insights
2018
Jin, J.; Moore, M.K.; Wilson, W.K.; Matsuda, S.P.T.
Org. Lett.
20
1802-1805
-
beta-Amyrin synthase, one of the most important key enzymes for triterpene skeleton formation in higher plants
2018
Ma, Y.; Yang, R.; Zhou, S.; Yin, Y.; Zhang, X.; Liu, Y.
Pak. J. Bot.
50
231-243
-
SNPs of dammarenediol synthase gene were associated with the accumulation of ginsenosides in DAMAYA ginseng, a cultivar of Panax ginseng C. A. Mey
2016
Cheng, C.; Wu, W.; Huang, B.; Liu, L.; Luo, P.; Zhou, H.
Phytochem. Lett.
17
194-200
Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi
2017
Zhang, D.H.; Li, N.; Yu, X.; Zhao, P.; Li, T.; Xu, J.W.
Phytochemistry
134
46-53
Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi
2017
Zhang, D.H.; Li, N.; Yu, X.; Zhao, P.; Li, T.; Xu, J.W.
Phytochemistry
134
46-53
Production of dammarane-type sapogenins in rice by expressing the dammarenediol-II synthase gene from Panax ginseng C.A. Mey
2015
Huang, Z.; Lin, J.; Cheng, Z.; Xu, M.; Huang, X.; Yang, Z.; Zheng, J.
Plant Sci.
239
106-114
Production of dammarane-type sapogenins in rice by expressing the dammarenediol-II synthase gene from Panax ginseng C.A. Mey
2015
Huang, Z.; Lin, J.; Cheng, Z.; Xu, M.; Huang, X.; Yang, Z.; Zheng, J.
Plant Sci.
239
106-114
Lanosterol synthase-like is involved with differential accumulation of steroidal glycoalkaloids in potato
2017
Kumar, A.; Fogelman, E.; Weissberg, M.; Tanami, Z.; Veilleux, R.E.; Ginzberg, I.
Planta
246
1189-1202
Lanosterol synthase-like is involved with differential accumulation of steroidal glycoalkaloids in potato
2017
Kumar, A.; Fogelman, E.; Weissberg, M.; Tanami, Z.; Veilleux, R.E.; Ginzberg, I.
Planta
246
1189-1202
RNAi and homologous overexpression based functional approaches reveal triterpenoid synthase gene-cycloartenol synthase is involved in downstream withanolide biosynthesis in Withania somnifera
2016
Mishra, S.; Bansal, S.; Mishra, B.; Sangwan, R.S.; Asha, R.S.; Jadaun, J.S.; Sangwan, N.S.
PLoS ONE
11
e0149691
RNAi and homologous overexpression based functional approaches reveal triterpenoid synthase gene-cycloartenol synthase is involved in downstream withanolide biosynthesis in Withania somnifera
2016
Mishra, S.; Bansal, S.; Mishra, B.; Sangwan, R.S.; Asha, R.S.; Jadaun, J.S.; Sangwan, N.S.
PLoS ONE
11
e0149691
Cloning and functional characterization of cycloartenol synthase from the red seaweed Laurencia dendroidea
2016
Calegario, G.; Pollier, J.; Arendt, P.; de Oliveira, L.S.; Thompson, C.; Soares, A.R.; Pereira, R.C.; Goossens, A.; Thompson, F.L.
PLoS ONE
11
e0165954
Cloning and functional characterization of cycloartenol synthase from the red seaweed Laurencia dendroidea
2016
Calegario, G.; Pollier, J.; Arendt, P.; de Oliveira, L.S.; Thompson, C.; Soares, A.R.; Pereira, R.C.; Goossens, A.; Thompson, F.L.
PLoS ONE
11
e0165954
The photosynthetic bacteria Rhodobacter capsulatus and Synechocystis sp. PCC 6803 as new hosts for cyclic plant triterpene biosynthesis
2017
Loeschcke, A.; Dienst, D.; Wewer, V.; Hage-Huelsmann, J.; Dietsch, M.; Kranz-Finger, S.; Hueren, V.; Metzger, S.; Urlacher, V.B.; Gigolashvili, T.; Kopriva, S.; Axmann, I.M.; Drepper, T.; Jaeger, K.E.
PLoS ONE
12
e0189816
The photosynthetic bacteria Rhodobacter capsulatus and Synechocystis sp. PCC 6803 as new hosts for cyclic plant triterpene biosynthesis
2017
Loeschcke, A.; Dienst, D.; Wewer, V.; Hage-Huelsmann, J.; Dietsch, M.; Kranz-Finger, S.; Hueren, V.; Metzger, S.; Urlacher, V.B.; Gigolashvili, T.; Kopriva, S.; Axmann, I.M.; Drepper, T.; Jaeger, K.E.
PLoS ONE
12
e0189816
Plant oxidosqualene metabolism cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana
2014
Gas-Pascual, E.; Berna, A.; Bach, T.J.; Schaller, H.
PLoS ONE
9
e109156-64
Plant oxidosqualene metabolism cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana
2014
Gas-Pascual, E.; Berna, A.; Bach, T.J.; Schaller, H.
PLoS ONE
9
e109156-64
An intronless beta-amyrin synthase gene is more efficient in oleanolic acid accumulation than its paralog in Gentiana straminea
2016
Liu, Y.; Zhao, Z.; Xue, Z.; Wang, L.; Cai, Y.; Wang, P.; Wei, T.; Gong, J.; Liu, Z.; Li, J.; Li, S.; Xiang, F.
Sci. Rep.
6
33364
An intronless beta-amyrin synthase gene is more efficient in oleanolic acid accumulation than its paralog in Gentiana straminea
2016
Liu, Y.; Zhao, Z.; Xue, Z.; Wang, L.; Cai, Y.; Wang, P.; Wei, T.; Gong, J.; Liu, Z.; Li, J.; Li, S.; Xiang, F.
Sci. Rep.
6
33364
Friedelin synthase from Maytenus ilicifolia leucine 482 plays an essential role in the production of the most rearranged pentacyclic triterpene
2016
Souza-Moreira, T.M.; Alves, T.B.; Pinheiro, K.A.; Felippe, L.G.; De Lima, G.M.; Watanabe, T.F.; Barbosa, C.C.; Santos, V.A.; Lopes, N.P.; Valentini, S.R.; Guido, R.V.; Furlan, M.; Zanelli, C.F.
Sci. Rep.
6
36858
Friedelin synthase from Maytenus ilicifolia leucine 482 plays an essential role in the production of the most rearranged pentacyclic triterpene
2016
Souza-Moreira, T.M.; Alves, T.B.; Pinheiro, K.A.; Felippe, L.G.; De Lima, G.M.; Watanabe, T.F.; Barbosa, C.C.; Santos, V.A.; Lopes, N.P.; Valentini, S.R.; Guido, R.V.; Furlan, M.; Zanelli, C.F.
Sci. Rep.
6
36858
Recombinant yeast as a functional tool for understanding bitterness and cucurbitacin biosynthesis in watermelon (Citrullus spp.)
2015
Davidovich-Rikanati, R.; Shalev, L.; Baranes, N.; Meir, A.; Itkin, M.; Cohen, S.; Zimbler, K.; Portnoy, V.; Ebizuka, Y.; Shibuya, M.; Burger, Y.; Katzir, N.; Schaffer, A.A.; Lewinsohn, E.; Tadmor, Y.
Yeast
32
103-114
Recombinant yeast as a functional tool for understanding bitterness and cucurbitacin biosynthesis in watermelon (Citrullus spp.)
2015
Davidovich-Rikanati, R.; Shalev, L.; Baranes, N.; Meir, A.; Itkin, M.; Cohen, S.; Zimbler, K.; Portnoy, V.; Ebizuka, Y.; Shibuya, M.; Burger, Y.; Katzir, N.; Schaffer, A.A.; Lewinsohn, E.; Tadmor, Y.
Yeast
32
103-114
Analysis of the mechanisms regulating the expression of isoprenoid biosynthesis genes in hydroponically-grown Nicotiana benthamiana plants using virus-induced gene silencing
2018
Atsumi, G.; Kagaya, U.; Tabayashi, N.; Matsumura, T.
Sci. Rep.
8
14804
Identification and functional characterization of squalene epoxidases and oxidosqualene cyclases from Tripterygium wilfordii
2020
Liu, Y.; Zhou, J.; Hu, T.; Lu, Y.; Gao, L.; Tu, L.; Gao, J.; Huang, L.; Gao, W.
Plant Cell Rep.
39
409-418
An unexpected oxidosqualene cyclase acctive site architecture in the Iris tectorum multifunctional alpha-amyrin synthase
2020
Wu, S.; Zhang, F.; Xiong, W.; Molnar, I.; Liang, J.; Ji, A.; Wang, C.; Wang, S.; Liu, Z.; Wu, R.; Duan, L.
ACS Catal.
10
9515-9520
Engineering critical amino acid residues of lanosterol synthase to improve the production of triterpenoids in Saccharomyces cerevisiae
2022
Guo, H.; Wang, H.; Chen, T.; Guo, L.; Blank, L.M.; Ebert, B.E.; Huo, Y.X.
ACS Synth. Biol.
11
2685-2696
Productive amyrin synthases for efficient alpha-amyrin synthesis in engineered Saccharomyces cerevisiae
2018
Yu, Y.; Chang, P.; Yu, H.; Ren, H.; Hong, D.; Li, Z.; Wang, Y.; Song, H.; Huo, Y.; Li, C.
ACS Synth. Biol.
7
2391-2402
Functional characterization of a cycloartenol synthase and four glycosyltransferases in the biosynthesis of cycloastragenol-type astragalosides from Astragalus membranaceus
2022
Duan, Y.; Du, W.; Song, Z.; Chen, R.; Xie, K.; Liu, J.; Chen, D.; Dai, J.
Acta Pharm. Sin. B
13
271-283
-
Cloning and functional characterization of the beta-amyrin synthase gene from Bupleurum chinense
2020
Li, J.; Wang, C.; Qi, W.; Liu, C.
Biol. Plant.
64
314-319
Identification of triterpene biosynthetic genes from Momordica charantia using RNA-seq analysis
2019
Takase, S.; Kera, K.; Hirao, Y.; Hosouchi, T.; Kotake, Y.; Nagashima, Y.; Mannen, K.; Suzuki, H.; Kushiro, T.
Biosci. Biotechnol. Biochem.
83
251-261
Oryza sativa parkeol cyclase changes in the substrate-folding conformation and the deprotonation sites on mutation at Tyr257 importance of the hydroxy group and steric bulk
2019
Suzuki, A.; Aikawa, Y.; Ito, R.; Hoshino, T.
ChemBioChem
20
2862-2875
Molecular docking and molecular dynamics studies on selective synthesis of alpha-amyrin and beta-amyrin by oxidosqualene cyclases from Ilex asprella
2019
Wu, Z.; Xu, H.; Wang, M.; Zhan, R.; Chen, W.; Zhang, R.; Kuang, Z.; Zhang, F.; Wang, K.; Gu, J.
Int. J. Mol. Sci.
20
3469
Engineering Saccharomyces cerevisiae for hyperproduction of beta-amyrin by mitigating the inhibition effect of squalene on beta-amyrin synthase
2022
Du, M.M.; Zhu, Z.T.; Zhang, G.G.; Zhao, Y.Q.; Gao, B.; Tao, X.Y.; Liu, M.; Ren, Y.H.; Wang, F.Q.; Wei, D.Z.
J. Agric. Food Chem.
70
229-237
Oxidosqualene cyclases involved in the biosynthesis of diverse triterpenes in Camellia sasanqua
2022
Huang, L.; Hu, Y.; Huang, R.; Chen, J.; Zhang, X.; Yue, J.; Feng, L.; She, Y.; Ji, A.; Zheng, Y.; Liu, Z.; Zhang, R.; Duan, L.
J. Agric. Food Chem.
70
8075-8084
Characterization of a group of 2,3-oxidosqualene cyclase genes involved in the biosynthesis of diverse triterpenoids of Perilla frutescens
2023
Huang, R.; Wu, D.; Ji, Z.; Fan, B.; She, Y.; Zhang, X.; Duan, L.; Shen, Q.
J. Agric. Food Chem.
71
2523-2531
-
Molecular docking studies of Chenopodium album linn with lanosterol synthase enzyme
2021
Madhuri, J.; Goteti, L.
J. Appl. Nat. Sci.
13
491-495
A cycloartenol synthase from the steroidal saponin biosynthesis pathway of Paris polyphylla
2021
Guo, S.Y.; Yin, Y.; Lei, T.; Shi, Y.H.; Gao, W.; Zhang, X.N.; Li, J.
J. Asian Nat. Prod. Res.
23
353-362
Biosynthesis of cycloartenol by expression of plant and bacterial oxidosqualene cyclases in engineered Rhodobacter capsulatus
2019
Hage-Hülsmann, J.; Metzger, S.; Wewer, V.; Buechel, F.; Troost, K.; Thies, S.; Loeschcke, A.; Jaeger, K.; Drepper, T.
J. Biotechnol.
S4
100014
Modification of isoprene synthesis to enable production of curcurbitadienol synthesis in Saccharomyces cerevisiae
2019
Qiao, J.; Luo, Z.; Cui, S.; Zhao, H.; Tang, Q.; Mo, C.; Ma, X.; Ding, Z.
J. Ind. Microbiol. Biotechnol.
46
147-157
Molecular cloning, functional characterization and expression of the beta-amyrin synthase gene involved in saikosaponin biosynthesis in Bupleurum chinense DC
2022
Mao, Y.; Chen, H.; Zhao, J.; Li, Y.; Feng, L.; Yang, Y.; Zhang, Y.; Wei, P.; Hou, D.
J. Plant Biochem. Biotechnol.
16
1-12
Enhanced production of amyrin in Yarrowia lipolytica using a combinatorial protein and metabolic engineering approach
2022
Kong, J.; Miao, L.; Lu, Z.; Wang, S.; Zhao, B.; Zhang, C.; Xiao, D.; Teo, D.; Leong, S.S.J.; Wong, A.; Yu, A.
Microb. Cell Fact.
21
186
Identification of a novel specific cucurbitadienol synthase allele in Siraitia grosvenorii correlates with high catalytic efficiency
2019
Qiao, J.; Luo, Z.; Gu, Z.; Zhang, Y.; Zhang, X.; Ma, X.
Molecules
24
627
Friedelane-type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast
2019
Zhou, J.; Hu, T.; Gao, L.; Su, P.; Zhang, Y.; Zhao, Y.; Chen, S.; Tu, L.; Song, Y.; Wang, X.; Huang, L.; Gao, W.
New Phytol.
223
722-735
Identification of oxidosqualene cyclases from the medicinal legume tree Bauhinia forficata a step toward discovering preponderant alpha-amyrin-producing activity
2019
Srisawat, P.; Fukushima, E.O.; Yasumoto, S.; Robertlee, J.; Suzuki, H.; Seki, H.; Muranaka, T.
New Phytol.
224
352-366
Modulation of Arabidopsis root growth by specialized triterpenes
2021
Bai, Y.; Fernandez-Calvo, P.; Ritter, A.; Huang, A.C.; Morales-Herrera, S.; Bicalho, K.U.; Karady, M.; Pauwels, L.; Buyst, D.; Njo, M.; Ljung, K.; Martins, J.C.; Vanneste, S.; Beeckman, T.; Osbourn, A.; Goossens, A.; Pollier, J.
New Phytol.
230
228-243
Mutated variants of squalene-hopene cyclase enzymatic syntheses of triterpenes bearing oxygen-bridged monocycles and a new 6,6,6,6,6-fusded pentacyclic scaffold, named neogammacerane, from 2,3-oxidosqualene
2018
Fukuda, Y.; Watanabe, T.; Hoshino, T.
Org. Biomol. Chem.
16
8365-8378
Cloning and characterization of oxidosqualene cyclases involved in taraxasterol, taraxerol and bauerenol triterpene biosynthesis in Taraxacum coreanum
2019
Han, J.Y.; Jo, H.J.; Kwon, E.K.; Choi, Y.E.
Plant Cell Physiol.
60
1595-1603
CYP712K4 catalyzes the C-29 oxidation of friedelin in the Maytenus ilicifolia quinone methide triterpenoid biosynthesis pathway
2019
Bicalho, K.U.; Santoni, M.M.; Arendt, P.; Zanelli, C.F.; Furlan, M.; Goossens, A.; Pollier, J.
Plant Cell Physiol.
60
2510-2522
De novo transcriptome analysis and identification of candidate genes associated with triterpenoid biosynthesis in Trichosanthes cucumerina L
2021
Lertphadungkit, P.; Qiao, X.; Sirikantaramas, S.; Satitpatipan, V.; Ye, M.; Bunsupa, S.
Plant Cell Rep.
40
1845-1858
Reciprocal mutations of two multifunctional beta-amyrin synthases from Barbarea vulgaris shift alpha/beta-amyrin ratios
2022
Guenther, J.; Erthmann, P.?.; Khakimov, B.; Bak, S.
Plant Physiol.
188
1483-1495
Transcriptome analysis and functional characterization of oxidosqualene cyclases of the arjuna triterpene saponin pathway
2020
Srivastava, G.; Sandeep, G.; Garg, A.; Misra, R.C.; Chanotiya, C.S.; Ghosh, S.
Plant Sci.
292
110382
Expression characteristics and function of CAS and a new beta-amyrin synthase in triterpenoid synthesis in birch (Betula platyphylla Suk.)
2020
Yin, J.; Yang, J.; Ma, H.; Liang, T.; Li, Y.; Xiao, J.; Tian, H.; Xu, Z.; Zhan, Y.
Plant Sci.
294
110433
Functional characterization of an oxidosqualene cyclase (PdFRS) encoding a monofunctional friedelin synthase in Populus davidiana
2019
Han, J.Y.; Ahn, C.H.; Adhikari, P.B.; Kondeti, S.; Choi, Y.E.
Planta
249
95-111
Characterization of oxidosqualene cyclases from Trichosanthes cucumerina L. reveals key amino acids responsible for substrate specificity of isomultiflorenol synthase
2022
Lertphadungkit, P.; Qiao, X.; Ye, M.; Bunsupa, S.
Planta
256
58
Genome mining and gene expression reveal maytansine biosynthetic genes from endophytic communities living inside Gymnosporia heterophylla (Eckl. and Zeyh.) Loes. and the relationship with the plant biosynthetic gene, friedelin synthase
2022
Pitakbut, T.; Spiteller, M.; Kayser, O.
Plants (Basel)
11
321
Target identification reveals lanosterol synthase as a vulnerability in glioma
2019
Phillips, R.E.; Yang, Y.; Smith, R.C.; Thompson, B.M.; Yamasaki, T.; Soto-Feliciano, Y.M.; Funato, K.; Liang, Y.; Garcia-Bermudez, J.; Wang, X.; Garcia, B.A.; Yamasaki, K.; McDonald, J.G.; Birsoy, K.; Tabar, V.; Allis, C.D.
Proc. Natl. Acad. Sci. USA
116
7957-7962
Activity and function studies of the promoter cis-acting elements of the key enzymes in saponins biosynthesis of DS from Panax notoginseng
2022
Zheng, Y.; Shao, R.; Xia, P.; Liang, Z.; Yan, K.
Protoplasma
259
163-171
Oxidosqualene cyclases involved in the biosynthesis of triterpenoids in Quercus suber cork
2020
Busta, L.; Serra, O.; Kim, O.T.; Molinas, M.; Pere-Fossoul, I.; Figueras, M.; Jetter, R.
Sci. Rep.
10
8011
Improving lupeol production in yeast by recruiting pathway genes from different organisms
2019
Qiao, W.; Zhou, Z.; Liang, Q.; Mosongo, I.; Li, C.; Zhang, Y.
Sci. Rep.
9
2992
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