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Ligand D-ascorbate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C6 H8 O6
D-ascorbate
CIWBSHSKHKDKBQ-DULSJSCMSA-N
D-erythro-ascorbic acid, D-xyloascorbic acid
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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2 D-ascorbate + H2O2 + 2 H+ = D-ascorbate + D-dehydroascorbate + 2 H2O
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dopamine + D-xyloascorbic acid + O2 = ?
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1-aminocyclopropane-1-carboxylate + D-ascorbate + O2 = ethylene + cyanide + D-dehydroascorbate + CO2 + H2O
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Product in Enzyme-catalyzed Reactions (4 results)
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2 D-ascorbate + H2O2 + 2 H+ = D-ascorbate + D-dehydroascorbate + 2 H2O
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2 L-ascorbate + H2O2 + 2 H+ = D-ascorbate + L-dehydroascorbate + 2 H2O
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L-gulono-gamma-lactone + ferricytochrome = D-ascorbate + ferricytochrome c
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L-mannono-gamma-lactone + ferricytochrome c = D-ascorbate + ferricytochrome c
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Activator in Enzyme-catalyzed Reactions (1 result)
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99% activity with D-ascorbate as compared to L-ascorbate
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Enzyme Kinetic Parameters
KM Value (2 results)
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1.7
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recombinant enzyme, in presence of 5 mM L-ascorbate and 10 mM HCO3-, pH 7.2, 28°C
References & Links Literature References (5)
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Activities of D- and L-xyloascorbic acid and D- and L-araboascorbic acid as a cofactor for dopamine b-hydroxylase reaction
1997
Suzuki, E.; Kurata, T.; Shiabata, M.; Mori, M.; Arakawa, N.
J. Nutr. Sci. Vitaminol.
43
491-496
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Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli
1995
Zhang, Z.; Schofield, C.J.; Baldwin, J.E.; Thomas, P.; John, P.
Biochem. J.
307
77-85
Phycobilin biosynthesis: Reductant requirements and product identification for heme oxygenase from Cyanidium caldarium
1995
Rhie, G.; Beale, S.
Arch. Biochem. Biophys.
320
182-194
Candida albicans erythroascorbate peroxidase regulates intracellular methylglyoxal and reactive oxygen species independently of D-erythroascorbic acid
2015
Kwak, M.K.; Song, S.H.; Ku, M.; Kang, S.O.
FEBS Lett.
589
1863-1871
Cytochrome c peroxidase regulates intracellular reactive oxygen species and methylglyoxal via enzyme activities of erythroascorbate peroxidase and glutathione-related enzymes in Candida albicans
2017
Shin, Y.; Lee, S.; Ku, M.; Kwak, M.K.; Kang, S.O.
Int. J. Biochem. Cell Biol.
92
183-201
Links to other databases for D-ascorbate
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