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Ligand 5-phospho-alpha-D-ribose 1-diphosphate

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Basic Ligand Information

Molecular Structure
Picture of 5-phospho-alpha-D-ribose 1-diphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C5H13O14P3
5-phospho-alpha-D-ribose 1-diphosphate
PQGCEDQWHSBAJP-TXICZTDVSA-N
Synonyms:
1-O-[hydroxy(phosphonooxy)phosphoryl]-5-O-phosphono-alpha-D-ribofuranose, 5-alpha-D-phosphorylribose 1-diphosphate, 5-phospho-alpha-D-ribose-1-diphosphate, 5-phospho-alpha-D-ribosyl-1-diphosphate, 5-phospho-alpha-D-ribosyl 1-diphosphate, 5-phospho-D-ribose diphosphate, 5-phospho-D-ribosyl 1-diphosphate, 5-phosphoribose 1-diphosphate, 5-phosphoribose 1-pyrophosphate, 5-phosphoribosyl diphosphate, alpha-D-5-phosphoribose 1-diphosphate, alpha-D-5-phosphoribosyl-1-diphosphate, alpha-D-5-phosphoribosyl 1-diphosphate, D-5-phosphoribosyl-1-diphosphate, D-ribose 1-diphosphate 5-phosphate, phosphoribose diphosphate, phosphoribosyl-5-phosphate, phosphoribosyl diphosphate, phosphoribosyldiphosphate, pyrophosphorylribose 5-phosphate

Related pathways

Pathway Source
Pathways
MetaCyc
(aminomethyl)phosphonate degradation, 5-aminoimidazole ribonucleotide biosynthesis I, 5-aminoimidazole ribonucleotide biosynthesis II, adenine and adenosine salvage I, adenine and adenosine salvage II more


Show all pahtways known for Show all BRENDA pathways known for 5-phospho-alpha-D-ribose 1-diphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (215 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate = trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
show the reaction diagram
neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate
show the reaction diagram
-
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
show the reaction diagram
-
ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (125 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (974 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate = trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
show the reaction diagram
neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate
show the reaction diagram
-
phosphoribosyl diphosphate + H2O = ?
show the reaction diagram
-
5-phospho-alpha-D-ribose 1-diphosphate + H2O = 5-phospho-alpha-D-ribose 1-phosphate + phosphate
show the reaction diagram
-
NH3 + phosphoribosyl diphosphate = phosphoribosyl amine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (217 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
show the reaction diagram
-
-
ATP + ribose 1,5-bisphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ADP
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
3-4fold activation of glutaminase activity in the presence of phosphate or diphosphate
-
5fold increase in Vmax at 20 mM
-
activation, kinetics, much more effective than fructose 1,6-diphosphate or glucose 1,6-diphosphate
-

Inhibitor in Enzyme-catalyzed Reactions (95 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
PRPP, inorganic polyphosphates, affinity of 5-phosphoribose 1-pyrophosphate for the enzyme is dependent on the activator concentration , inhibition mechanism with 5-phosphoribose 1-pyrophosphate is competitive with GTP
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1639 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (166 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.23
-
pH 4.8, 70°C
0.1
-
in the presence of 10 mM Mg2+, at pH 9.0 and 26°C

KM Value (349 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.13
-
in the presence of 10 mM Mg2+, at pH 9.0 and 26°C
0.0034
-
-

Ki Value (23 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.021
-
-

References & Links

Links to other databases for 5-phospho-alpha-D-ribose 1-diphosphate

EXTERNAL LINKS