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Ligand halothane Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C2 HBrClF3
halothane
BCQZXOMGPXTTIC-UHFFFAOYSA-N
Roles as Enzyme Ligand
Inhibitor in Enzyme-catalyzed Reactions (5 results)
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non-competitive inhibitor
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induces a transient decrease in leukotriene omega-oxidation both in vivo and in vitro, halothane metabolism-dependent trifluoracetylation of hepatic target proteins might play a role in the inactivation of the enzyme
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allosteric modulation of dynamics-function relationship without direct competition, halothane occupancy at the dimer interface disrupts intersubunit hydrogen bonding
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Enzyme Kinetic Parameters
References & Links Literature References (5)
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Effects of general anesthetics on the bacterial luciferase enzyme from Vibrio harveyi: an anesthetic target site with differential sensitivity
1990
Curry, S.; Lieb, W.R.; Franks, N.P.
Biochemistry
29
4641-4652
Thermodynamics of anesthetic /protein interactions
1993
Dickinson, R.; Franks, N.P.; Lieb, W.R.
Biophys. J.
64
1264-1271
Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro
1992
Huwyler, J.; Jedlitschky, G.; Keppler, D.; Gut, J.
Eur. J. Biochem.
206
869-897
Anesthetic interaction with ketosteroid isomerase: Insights from molecular dynamics simulations
2005
Yonkunas, M.J.; Xu, Y.; Tang, P.
Biophys. J.
89
2350-2356
Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions
2010
Inouye, S.
Cell. Mol. Life Sci.
67
387-404
Links to other databases for halothane
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