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BRENDA support

Ligand 1,6-diaminohexane

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Basic Ligand Information

Molecular Structure
Picture of 1,6-diaminohexane (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C6H16N2
1,6-diaminohexane
NAQMVNRVTILPCV-UHFFFAOYSA-N
Synonyms:
1,6 diaminohexane, 1,6-hexamethylenediamine, 1,6-hexane diamine, 1,6-hexanediamine, diaminohexane, hexamethylenediamine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,6-diaminohexane + pyruvate = 1-aminohexane + alanine
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,6-diaminohexane + H2O + O2 = 6-aminohexanal + NH3 + H2O2
show the reaction diagram
-
1,6-diaminohexane + acceptor + H2O = ?
show the reaction diagram
-
1,6-diaminohexane + H2O + 2,6-dichlorophenol indophenol = ? + NH3 + reduced 2,6-dichlorophenol indophenol
show the reaction diagram
-
carbamoyl phosphate + 1,6-diaminohexane = phosphate + N1-carbamoyl-1,6-diaminohexane
show the reaction diagram
-
caffeoyl-CoA + diaminohexane = CoA + N-caffeoyl-1,6-diaminohexane
show the reaction diagram
-
acetyl-CoA + 1,6-hexanediamine = ?
show the reaction diagram
-
acetyl-CoA + 1,6-diaminohexane = CoA + N1-acetyl-1,6-diaminohexane
show the reaction diagram
-
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,6-diaminohexane = ?
show the reaction diagram
-
1,6-diaminohexane + pyruvate = 1-aminohexane + alanine
show the reaction diagram
-
1,6-hexamethylenediamine + propionaldehyde = ? + 1-aminopropane
show the reaction diagram
-
1,6-diaminohexane + 2-oxoglutarate = 6-aminohexanal + L-glutamate
show the reaction diagram
-
1,6-diaminohexane + pyruvate = ? + L-alanine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-carbamoyldiaminohexane + H2O = CO2 + NH3 + diaminohexane
show the reaction diagram
-
1-amino-6-guanidinohexane + H2O = 1,6-diaminohexane + urea
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
58% of activation by putrescine
-

Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
97% of initial activity at 2 mM
-
43% inhibition
-
weaker inhibitor
-
30% inhibition
-
23% inhibition
-
23.9% inhibition at 10 mM
-
Ki: 1.5 mM
-
inhibition arises from the displacement of the metal-bridging water

3D Structure of Enzyme-Ligand-Complex (PDB) (52 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.37
-
wild type enzyme, in 50 mM Tris-HCl buffer, pH 8.0, at 25°C
17580
-
pH 7.2, 37°C

KM Value (10 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.17
-
wild type enzyme, in 50 mM Tris-HCl buffer, pH 8.0, at 25°C
6.6
-
-
0.4
-
-

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.023
-
-
0.003
-
pH 6.0, 25°C
1.5
-
-
0.0024
-
-

References & Links

Links to other databases for 1,6-diaminohexane

EXTERNAL LINKS