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The procaryotic nature of the fatty acid synthetase of developing Carthamus tinctorius L. (Safflower) seeds
1982
Shimakata, T.; Stumpf, P.K.
Arch. Biochem. Biophys.
217
144-154
Covalent reaction of cerulenin at the active site of acyl-CoA reductase of Photobacterium phosphoreum
1989
Wall, L.; Meighen, E.
Biochem. Cell Biol.
67
163-167
Early catalytic steps of Euglena gracilis chloroplast type II fatty acid synthase
1993
Worsham, L.M.S.; Williams, S.G.; Ernst-Fonberg, M.L.
Biochim. Biophys. Acta
1170
62-71
Acetoacyl-acyl carrier protein synthase from avocado: its purification, characterization and clear resolution from acetyl CoA: ACP transacylase
1994
Gulliver, B.S.; Slabas, A.R.
Plant Mol. Biol.
25
179-191
Purification and characterization of beta-ketoacyl-[acyl-carrier-protein] synthetase I from Spinacia oleracea leaves
1983
Shimakata, T.; Stumpf, P.L.
Arch. Biochem. Biophys.
220
39-45
-
A new assay procedure to study the induction of beta-ketoacyl-ACP synthase I and II, and the complete purification of beta-ketoacyl-ACP synthase I from developing seeds of oilseed rape (Brassica napus)
1989
MacKintosh, R.W.; Hardie, D.G.; Slabas, A.R.
Biochim. Biophys. Acta
1002
114-124
Isolation and function of spinach leaf beta-ketoacyl-[acyl-carrier-protein] synthases
1982
Shimakata, T.; Stumpf, P.L.
Proc. Natl. Acad. Sci. USA
79
5808-5812
Biochemical characterization of 3-ketoacyl-acyl carrier protein synthase II from leek epidermis
2000
Domergue, F.; Post-Beittenmiller, D.
Biochem. Soc. Trans.
28
610-613
Re-engineering ketoacyl synthase specificity
2000
Val, D.; Banu, G.; Seshadri, K.; Lindqvist, Y.; Dehesh, K.
Structure
8
565-566
Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)
2001
Khandekar, S.S.; Gentry, D.R.; Van Aller, G.S.; Warren, P.; Xiang, H.; Silverman, C.; Doyle, M.L.; Chambers, P.A.; Konstantinidis, A.K.; Brandt, M.; Daines, R.A.; Lonsdale, J.T.
J. Biol. Chem.
276
30024-30030
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism
2001
Price, A.C.; Choi, K.H.; Heath, R.J.; Li, Z.; White, S.W.; Rock, C.O.
J. Biol. Chem.
276
6551-6559
Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
2002
He, X.; Reynolds, K.A.
Antimicrob. Agents Chemother.
46
1310-1318
beta-Ketoacyl-acyl carrier protein synthase IV: a key enzyme for regulation of medium-chain fatty acid synthesis in Cuphea lanceolata seeds
2002
Schutt, B.S.; Abbadi, A.; Loddenkotter, B.; Brummel, M.; Spener, F.
Planta
215
847-854
An unusual seed-specific 3-ketoacyl-ACP synthase associated with the biosynthesis of petroselinic acid in coriander
2001
Mekhedov, S.; Cahoon, E.B.; Ohlrogge, J.
Plant Mol. Biol.
47
507-518
The role of cysteines in polyketide synthases. Site-directed mutagenesis of resveratrol and chalcone synthases, two key enzymes in different plant-specific pathways
1991
Lanz, T.; Tropf, S.; Marner, F.J.; Schröder, J.; Schröder, G.
J. Biol. Chem.
266
9971-9976
Chalcone synthase from cell suspension cultures of Daucus carota L
1985
Hinderer, W.; Seitz, H.U.
Arch. Biochem. Biophys.
240
265-272
-
Chalcone synthase from cell suspension cultures of phaseolus vulgaris L.
1983
Whitehead, I.M.; Dixon, R.A.
Biochim. Biophys. Acta
747
298-303
The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action
1983
Tsukamoto, Y.; Wong, H.; Mattick, J.S.; Wakil, S.J.
J. Biol. Chem.
258
15312-15322
Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site
2002
Jia, N.; Arthington-Skaggs, B.; Lee, W.; Pierson, C.A.; Lees, N.D.; Eckstein, J.; Barbuch, R.; Bard, M.
Antimicrob. Agents Chemother.
46
947-957
Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis
2004
Olsen, J.G.; Rasmussen, A.V.; von Wettstein-Knowles, P.; Henriksen, A.
FEBS Lett.
577
170-174
Identification and molecular characterization of the beta-ketoacyl-[acyl carrier protein] synthase component of the Arabidopsis mitochondrial fatty acid synthase
2004
Yasuno, R.; von Wettstein-Knowles, P.; Wada, H.
J. Biol. Chem.
279
8242-8251
Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain
2005
Zhang, L.; Joshi, A.K.; Hofmann, J.; Schweizer, E.; Smith, S.
J. Biol. Chem.
280
12422-12429
Inhibition of fatty acid synthase prevents preadipocyte differentiation
2005
Schmid, B.; Rippmann, J.F.; Tadayyon, M.; Hamilton, B.S.
Biochem. Biophys. Res. Commun.
328
1073-1082
Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates
2005
Rendina, A.R.; Cheng, D.
Biochem. J.
388
895-903
Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells
2004
Agostini, M.; Silva, S.D.; Zecchin, K.G.; Coletta, R.D.; Jorge, J.; Loda, M.; Graner, E.
Oral Oncol.
40
728-735
-
Bovine leukemia virus retropepsin
2004
Menard, A.; Guillemain, B.
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
169-171
Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs
2007
Ngo, S.C.; Zimhony, O.; Chung, W.J.; Sayahi, H.; Jacobs, W.R.; Welch, J.T.
Antimicrob. Agents Chemother.
51
2430-2435
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma
2006
Na, M.; Jang, J.; Min, B.S.; Lee, S.J.; Lee, M.S.; Kim, B.Y.; Oh, W.K.; Ahn, J.S.
Bioorg. Med. Chem. Lett.
16
4738-4742
Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
2006
Lupu, R.; Menendez, J.A.
Curr. Pharm. Biotechnol.
7
483-494
Recombinant expression and biochemical characterization of the unique elongating beta-ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of Plasmodium falciparum using natural and artificial substrates
2006
Lack, G.; Homberger-Zizzari, E.; Folkers, G.; Scapozza, L.; Perozzo, R.
J. Biol. Chem.
281
9538-9546
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
2006
Wang, J.; Soisson, S.M.; Young, K.; Shoop, W.; Kodali, S.; Galgoci, A.; Painter, R.; Parthasarathy, G.; Tang, Y.S.; Cummings, R.; Ha, S.; Dorso, K.; Motyl, M.; Jayasuriya, H.; Ondeyka, J.; Herath, K.; Zhang, C.; Hernandez, L.; Allocco, J.; Basilio, A.; Tormo, J.R.; Genilloud, O.; Vicente, F.; Pelaez, F.
Nature
441
358-361
Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase
2007
Christensen, C.E.; Kragelund, B.B.; von Wettstein-Knowles, P.; Henriksen, A.
Protein Sci.
16
261-272
Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI)
2009
Sampson, P.B.; Picard, C.; Handerson, S.; McGrath, T.E.; Domagala, M.; Leeson, A.; Romanov, V.; Awrey, D.E.; Thambipillai, D.; Bardouniotis, E.; Kaplan, N.; Berman, J.M.; Pauls, H.W.
Bioorg. Med. Chem. Lett.
19
5355-5358
Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection
2009
Nguyen, L.N.; Trofa, D.; Nosanchuk, J.D.
PLoS ONE
4
e8421
Endogenous H2O2 produced by Streptococcus pneumoniae controls FabF activity
2010
Benisty, R.; Cohen, A.Y.; Feldman, A.; Cohen, Z.; Porat, N.
Biochim. Biophys. Acta
1801
1098-1104
Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener
2010
Du, Y.; Gisselberg, J.E.; Johnson, J.D.; Lee, P.J.; Prigge, S.T.; Bachmann, B.O.
Appl. Environ. Microbiol.
76
3959-3966
-
In silico screening of a novel inhibitor of beta-ketoacyl acyl carrier protein synthase i
2011
Lee, J.; Jeong, K.; Lee, J.; Kang, D.; Kim, Y.
Bull. Korean Chem. Soc.
32
1645-1649
Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity
2013
Oh, J.; Hwang, I.H.; Hong, C.E.; Lyu, S.Y.; Na, M.
J. Enzyme Inhib. Med. Chem.
28
565-568
Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents
2013
Wang, Y.; Ma, S.
ChemMedChem
8
1589-1608
Thiolactomycin-based beta-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy
2013
Kapilashrami, K.; Bommineni, G.R.; Machutta, C.A.; Kim, P.; Lai, C.T.; Simmerling, C.; Picart, F.; Tonge, P.J.
J. Biol. Chem.
288
6045-6052
Docking studies of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli
2015
Sabbagh, G.; Berakdar, N.
J. Mol. Graph. Model.
61
214-223
Structural characterisation of the beta-ketoacyl-acyl carrier protein synthases, FabF and FabH, of Yersinia pestis
2015
Nanson, J.D.; Himiari, Z.; Swarbrick, C.M.; Forwood, J.K.
Sci. Rep.
5
14797
Crystal structures of Xanthomonas campestris OleA reveal features that promote head-to-head condensation of two long-chain fatty acids
2012
Goblirsch, B.; Frias, J.; Wackett, L.; Wilmot, C.
Biochemistry
51
4138-4146
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB
2001
Schaeffer, M.L.; Agnihotri, G.; Volker, C.; Kallender, H.; Brennan, P.J.; Lonsdale, J.T.
J. Biol. Chem.
276
47029-47037
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB
2001
Schaeffer, M.L.; Agnihotri, G.; Volker, C.; Kallender, H.; Brennan, P.J.; Lonsdale, J.T.
J. Biol. Chem.
276
47029-47037
N-acylated derivatives of sulfamethoxazole block chlamydia fatty acid synthesis and interact with FabF
2017
Mojica, S.A.; Salin, O.; Bastidas, R.J.; Sunduru, N.; Hedenstroem, M.; Andersson, C.D.; Nunez-Otero, C.; Engstroem, P.; Valdivia, R.H.; Elofsson, M.; Gylfe, A.
Antimicrob. Agents Chemother.
61
e00716-17
N-acylated derivatives of sulfamethoxazole block chlamydia fatty acid synthesis and interact with FabF
2017
Mojica, S.A.; Salin, O.; Bastidas, R.J.; Sunduru, N.; Hedenstroem, M.; Andersson, C.D.; Nunez-Otero, C.; Engstroem, P.; Valdivia, R.H.; Elofsson, M.; Gylfe, A.
Antimicrob. Agents Chemother.
61
e00716-17
Roles of multiple KASIII homologues of Shewanella oneidensis in initiation of fatty acid synthesis and in cerulenin resistance
2018
Meng, Q.; Liang, H.; Gao, H.
Biochim. Biophys. Acta
1863
1153-1163
Roles of multiple KASIII homologues of Shewanella oneidensis in initiation of fatty acid synthesis and in cerulenin resistance
2018
Meng, Q.; Liang, H.; Gao, H.
Biochim. Biophys. Acta
1863
1153-1163
The Staphylococcus aureus FASII bypass escape route from FASII inhibitors
2017
Morvan, C.; Halpern, D.; Kenanian, G.; Pathania, A.; Anba-Mondoloni, J.; Lamberet, G.; Gruss, A.; Gloux, K.
Biochimie
141
40-46
The Staphylococcus aureus FASII bypass escape route from FASII inhibitors
2017
Morvan, C.; Halpern, D.; Kenanian, G.; Pathania, A.; Anba-Mondoloni, J.; Lamberet, G.; Gruss, A.; Gloux, K.
Biochimie
141
40-46
Improved pinocembrin production in Escherichia coli by engineering fatty acid synthesis
2016
Cao, W.; Ma, W.; Zhang, B.; Wang, X.; Chen, K.; Li, Y.; Ouyang, P.
J. Ind. Microbiol. Biotechnol.
43
557-566
Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites
2020
Patterson, E.I.; Nanson, J.D.; Abendroth, J.; Bryan, C.; Sankaran, B.; Myler, P.J.; Forwood, J.K.
Proteins
88
47-56
Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites
2020
Patterson, E.I.; Nanson, J.D.; Abendroth, J.; Bryan, C.; Sankaran, B.; Myler, P.J.; Forwood, J.K.
Proteins
88
47-56
Evaluation of mechanical features and antibacterial potential of fluoroquinolone against beta-ketoacyl-ACP synthases (FabB, FabF & FabH) via computational approaches
2023
Ejaz, S.A.; Aziz, M.; Wani, T.A.; Al-Kahtani, H.M.
Arch. Biochem. Biophys.
744
109674
Diversity in fatty acid elongation enzymes The FabB long-chain beta-ketoacyl-ACP synthase I initiates fatty acid synthesis in Pseudomonas putida F1
2024
Guo, Q.; Zhong, C.; Dong, H.; Cronan, J.E.; Wang, H.
J. Biol. Chem.
300
105600
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