Ligand 3,4-dimethoxy-5-hydroxybenzoic acid
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Basic Ligand Information
C9H10O5
3,4-dimethoxy-5-hydroxybenzoic acid
WFIBQVFJXGQICQ-UHFFFAOYSA-N
3-hydroxy-4,5-dimethoxybenzoate, 3-hydroxy-4,5-dimethoxybenzoic acid
Roles as Enzyme Ligand
Product in Enzyme-catalyzed Reactions (3 results)
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3,4,5-trimethoxybenzoate + O2 + NADH + H+ = 3-hydroxy-4,5-dimethoxybenzoate + NAD+ + H2O + formaldehyde
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3,4-dimethoxy-5-hydroxybenzaldehyde + NAD+ + H2O = 3,4-dimethoxy-5-hydroxybenzoic acid + NADH + H+
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3,4-dimethoxy-5-hydroxybenzaldehyde + NAD+ + H2O = 3,4-dimethoxy-5-hydroxybenzoic acid + NADH + H+
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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Enzyme Kinetic Parameters
Ki Value (3 results)
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References & Links
Literature References (4)
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Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates
1986
Ames, M.M.; Selassie, C.D.; Woodson, L.C.; Van Loon, J.A.; Hansch, C.; Weinshilboum, R.M.
J. Med. Chem.
29
354-358
Thiopurine methyltransferase isozymes in human renal tissue
1990
Van Loon, J.A.; Weinshilboum, R.M.
Drug Metab. Dispos.
18
632-638
Purine substrates for human thiopurine methyltransferase
1994
Deininger, M.; Szumlanski, C.L.; Otterness, D.M.; Van Loon, J.; Ferber, W.; Weinshilboum, R.M.
Biochem. Pharmacol.
48
2135-2138
Substrate range and genetic analysis of Acinetobacter vanillate demethylase
2000
Morawski, B.; Segura, A.; Ornston, L.N.
J. Bacteriol.
182
1383-1389
Links to other databases for 3,4-dimethoxy-5-hydroxybenzoic acid