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Ligand N-acetyl-L-glutamate 5-semialdehyde

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for N-acetyl-L-glutamate 5-semialdehyde

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.38

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH

390282, 390284, 390285, 390281, 390283, 390278, 390279, 390280

-

2.6.1.11

N-acetyl-L-glutamic gamma-semialdehyde + L-glutamate = N2-acetyl-L-ornithine + 2-oxoglutarate

644947, 644948, 644945

-

In Vivo Product in Enzyme-catalyzed Reactions (9 results)

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Show Natural Product (9 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.38

N-acetyl-L-glutamyl 5-phosphate + NADPH + H+ = N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate

0

-

2.3.1.271

acetyl-CoA + DELTA1-pyrroline-5-carboxylate + H2O = CoA + N-acetyl-glutamate-gamma-semialdehyde

0

-

2.3.1.271

acetyl-CoA + glutamate-gamma-semialdehyde = CoA + N-acetyl-glutamate-gamma-semialdehyde

0

-

2.3.1.271

acetyl-CoA + L-DELTA1-pyrroline 5-carboxylate + H2O = CoA + N-acetyl-glutamate-gamma-semialdehyde

0

-

2.3.1.271

acetyl-CoA + L-glutamate 5-semialdehyde = CoA + N-acetyl-L-glutamate 5-semialdehyde

0

-

2.3.1.271

acetyl-CoA + L-glutamate-5-semialdehyde = CoA + N-acetyl-L-glutamate 5-semialdehyde

0

-

2.6.1.11

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

0

-

2.6.1.11

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate-gamma-semialdehyde + L-glutamate

0

-

2.3.1.271

5 entries

2.6.1.11

2 entries

2.6.1.19

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

0

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.38

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH

390288, 390279, 390278, 390282, 390284, 390285, 390286, 390290, 1730, 390281, 390287, 390289, 390283, 390280

-

2.6.1.11

N-acetyl-L-glutamic gamma-semialdehyde + L-glutamate = N2-acetyl-L-ornithine + 2-oxoglutarate

671121, 644947, 644948, 644945

-

Product in Enzyme-catalyzed Reactions (15 results)

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Show Product (15 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.38

N-acetyl-5-glutamyl phosphate + NADPH + H+ = N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate

0

-

1.2.1.38

N-acetyl-L-glutamyl 5-phosphate + NADPH + H+ = N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate

0

-

2.3.1.271

acetyl-CoA + DELTA1-pyrroline-5-carboxylate + H2O = CoA + N-acetyl-glutamate-gamma-semialdehyde

0

-

2.3.1.271

acetyl-CoA + glutamate-gamma-semialdehyde = CoA + N-acetyl-glutamate-gamma-semialdehyde

0

-

2.3.1.271

acetyl-CoA + L-DELTA1-pyrroline 5-carboxylate + H2O = CoA + N-acetyl-glutamate-gamma-semialdehyde

0

-

2.3.1.271

acetyl-CoA + L-DELTA1-pyrroline-5-carboxylate + H2O = CoA + N-acetyl-glutamate-gamma-semialdehyde

0

-

2.3.1.271

acetyl-CoA + L-glutamate 5-semialdehyde = CoA + N-acetyl-L-glutamate 5-semialdehyde

0

-

2.3.1.271

acetyl-CoA + L-glutamate-5-semialdehyde = CoA + N-acetyl-L-glutamate 5-semialdehyde

0

-

2.6.1.11

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

0

-

2.6.1.11

N2-acetyl-L-ornithine + 2-oxohexanedioic acid = N-acetyl-L-glutamate 5-semialdehyde + 2-aminohexanedioic acid

0

-

2.6.1.11

Nalpha-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

644947, 0, 644946, 644950, 644945

-

2.6.1.11

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate-gamma-semialdehyde + L-glutamate

0

-

1.2.1.38

2 entries

2.3.1.271

6 entries

2.6.1.11

4 entries

2.6.1.13

N-acetylornithine + 2-oxoglutarate = glutamate + N-acetyl-glutamate-gammasemialdehyde

0

-

2.6.1.19

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

0

-

2.6.1.81

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

0

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.2.1.38

0.6

-

-

390280

References & Links

Literature References (20)

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Show Reference (20 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

1730

2420793

Simultaneous purification of three mitochondrial enzymes. Acetylglutamate kinase, acetylglutamyl-phosphate reductase and carbamoyl-phosphate synthetase from Neurospora crassa

1986

Wandinger-Ness, A.U.; Ness, S.A.; Weiss, R.L.

J. Biol. Chem.

261

4820-4827

390278

13863980

N-acetyl-gamma-glutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: Repressible enzymes of arginine synthesis in Escherichia coli

1962

Baich, A.; Vogel, H.J.

Biochem. Biophys. Res. Commun.

7

491-496

390279

5325238

Coordination of enzyme synthesis in the arginine pathway of Escherichia coli K-12

1965

Glansdorff, N.; Sand, G.

Biochim. Biophys. Acta

108

308-311

390280

-

N-Acetylglutamic gamma-semialdehyde dehydrogenase (Escherichia coli)

1970

Vogel, H.J.; McLellan, W.L.

Methods Enzymol.

17A

255-260

390281

166979

Organization and control in the arginine biosynthetic pathway of Neurospora

1975

Cybis, J.; Davis, R.H.

J. Bacteriol.

123

196-202

390282

-

Compartmentation of arginine biosynthesis in Saccharomyces cerivisiae

1977

Wipf, B.; Leisinger, T.

FEMS Microbiol. Lett.

2

239-242

390283

408599

The genetic organization of arginine biosynthesis in Pseudomonas aeruginosa

1977

Haas, D.; Holloway, B.W.

Mol. Gen. Genet.

154

7-22

390284

205532

Arginine metabolism in Saccharomyces cerevisiae: subcellular localization of the enzymes

1978

Jauniaux, J.C.; Urrestarazu, L.A.; Wiame, J.M.

J. Bacteriol.

133

1096-1107

390285

220508

Organization and expression of a two-gene cluster in the arginine biosynthesis of Saccharomyces cerevisiae

1979

Minet, M.; Jauniaux, J.C.; Thuriaux, P.; Grenson, M.; Wiame, J.M.

Mol. Gen. Genet.

168

299-308

390286

6251229

A cis-dominant regulatory mutation linked to the argB-argC gene cluster in Saccharomyces cerevisiae

1980

Jacobs, P.; Jauniaux, J.C.

J. Mol. Biol.

139

691-704

390287

2987210

Acetylglutamate kinase-acetylglutamyl-phosphate reductase complex of Neurospora crassa. Evidence for two polypeptides

1985

Wandinger-Ness, A.U.; Wolf, E.C.; Weiss, R.L.; Davis, R.H.

J. Biol. Chem.

260

5974-5978

390288

9493385

Genes and enzymes of the acetyl cycle of arginine biosynthesis in the extreme thermophilic bacterium Thermus thermophilus HB27

1998

Baetens, M.; Legrain, C.; Boyen, A.; Glansdorff, N.

Microbiology

144

479-492

390289

9525895

Processing and function of a polyprotein of two mitochondrial proteins in Neurospora crassa

1998

Parra-Gessert, L.; Koo, K.; Fajardo, J.; Weiss, R.L.

J. Biol. Chem.

273

7972-7980

390290

11553611

A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis. Acetylglutamate synthase activity requires complex formation with acetylglutamate kinase

2001

Abadjieva, A.; Pauwels, K.; Hilven, P.; Crabeel, M.

J. Biol. Chem.

276

42869-42880

644945

238949

Dual role for N-2-acetylornithine 5-aminotransferase from Pseudomonas aeruginosa in arginine biosynthesis and arginine catabolism

1975

Voellmy, R.; Leisinger, T.

J. Bacteriol.

122

799-809

644946

14213368

Acetylornithine delta-transaminase. Partial purification and repression behavior

1964

Albrecht, A.M.; Vogel, H.J.

J. Biol. Chem.

239

1872-1876

644947

8431

Ornithine delta-transaminase activity in Escherichia coli: its identity with acetylornithine delta-transaminase

1976

Billheimer, J.T.; Carnevale, H.N.; Leisinger, T.; Eckardt, T.; Jones, E.E.

J. Bacteriol.

127

1315-1323

644948

4599318

Inducible and repressible acetylornithine delta-transaminase in Escherichia coli: different proteins

1974

Billheimer, J.T.; Jones, E.E.

Arch. Biochem. Biophys.

161

647-651

644950

112925

Isolation and characterization of acetylornithine delta-transaminase of wild-type Escherichia coli W. Comparison with arginine-inducible acetylornithine delta-transaminase

1979

Billheimer, J.T.; Shen, M.Y.; Carnevale, H.N.; Horton, H.R.; Jones, E.E.

Arch. Biochem. Biophys.

195

401-413

671121

17012789

Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of the biosynthetic N-acetylornithine aminotransferases from Salmonella typhimurium and Escherichia coli

2006

Rajaram, V.; Prasad, K.; Ratna Prasuna, P.; Ramachandra, N.; Bharath, S.R.; Savithri, H.S.; Murthy, M.R.

Acta Crystallogr. Sect. F

62

980-983

Links to other databases for N-acetyl-L-glutamate 5-semialdehyde

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PubChem