Ligand 3-hydroxy-2-methylpyridine-4,5-dicarboxylate

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Basic Ligand Information

Molecular Structure
Picture of 3-hydroxy-2-methylpyridine-4,5-dicarboxylate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H7NO5
3-hydroxy-2-methylpyridine-4,5-dicarboxylate
LVJJEIJOKPHQOU-UHFFFAOYSA-N
Pathway Source
Pathways
KEGG
Microbial metabolism in diverse environments, Vitamin B6 metabolism
MetaCyc
vitamin B6 degradation

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-Hydroxy-2-methylpyridine-4,5-dicarboxylate = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD+ + H2O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (2 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD+ + H2O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+
show the reaction diagram
-
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

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EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.6
-
in 100 mM Tris-HCl at pH 8.0 containing 100 mM NaCl and 2 mM dithiothreitol

KM Value (2 results)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

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Links to other databases for 3-hydroxy-2-methylpyridine-4,5-dicarboxylate

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ChEBI
PubChem
ChEBI
PubChem