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BRENDA support

Ligand 2-dehydropantolactone

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Basic Ligand Information

Molecular Structure
Picture of 2-dehydropantolactone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H8O3
2-dehydropantolactone
HRTOQFBQOFIFEE-UHFFFAOYSA-N
Synonyms:
2-Dehydropantonolactone, 2-Dehydropantoyl lactone, dehydropantolactone, dihydro-4,4-dimethyl-2,3-furandione, ketopantoyl lactone, oxopantoyl lactone
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-dehydropantolactone + NADPH + H+ = (R)-pantolactone + NADP+
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydro-4,4-dimethyl-2,3-furandione + NADH + H+ = ?
show the reaction diagram
-
2-dehydropantolactone + NADPH + H+ = (R)-pantolactone + NADP+
show the reaction diagram
-
ketopantoyl lactone + NADPH + H+ = pantoyl lactone + NADP+
show the reaction diagram
-
ketopantoyl lactone + NADPH = NADP+ + ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pantolactone + oxidized acceptor = dehydropantolactone + reduced acceptor
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive versus isatin
-
20 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (11 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (21 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10
-
-
0.71
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.19
-
pH 7.0, 30°C, substrate: isatin

References & Links

Links to other databases for 2-dehydropantolactone

ChEBI
PubChem
ChEBI
PubChem