Ligand myo-inositol 1,3,4,5,6-pentakisphosphate

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Basic Ligand Information

Molecular Structure
Picture of myo-inositol 1,3,4,5,6-pentakisphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H17O21P5
myo-inositol 1,3,4,5,6-pentakisphosphate
CTPQAXVNYGZUAJ-KXXVROSKSA-N
Synonyms:
1,3,4,5,6-inositol pentakisphosphate, 1D-myo-inositol-1,3,4,5,6-pentakisphosphate, 1D-myo-inositol 1,3,4,5,6-pentakisphosphate, D-myo-inositol-1,3,4,5,6-pentakisphosphate, D-myo-inositol 1,3,4,5,6-pentakisphosphate, inositol (1,3,4,5,6)-pentakisphosphate, inositol-1,3,4,5,6-pentakisphosphate, Inositol 1,3,4,5,6-pentakisphosphate, Inositol pentakisphosphate, myo-inositol-1,3,4,5,6 pentakisphosphate, myo-inositol-1,3,4,5,6-pentakisphosphate, myo-inositol 1,3,4,5,6 pentakis(dihydrogen phosphate), myo-inositol pentakisphosphate (mixed isomers), myo-inositol polyphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphosphoinositol tetrakisphosphate
show the reaction diagram
-
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP = 1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP
show the reaction diagram
-
inositol 1,3,4,5,6-pentakisphosphate + H2O = inositol 1,4,5,6-tetrakisphosphate + phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
show the reaction diagram
-
ATP + myo-inositol 1,3,4,6-tetrakisphosphate = ADP + myo-inositol 1,3,4,5,6-pentakisphosphate
show the reaction diagram
-
inositol hexakisphosphate + H2O = inositol pentakisphosphate + phosphate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP = 1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP
show the reaction diagram
-
ATP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate
show the reaction diagram
-
inositol 1,3,4,5,6-pentakisphosphate + H2O = inositol 1,4,5,6-tetrakisphosphate + phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (43 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
show the reaction diagram
-
myo-inositol hexakisphosphate + H2O = L-myo-inositol 1,2,3,4,5-pentakisphosphate + myo-inositol 1,2,3,4,6-pentakisphosphate + myo-inositol 1,3,4,5,6-pentakisphosphate + myo-inositol 2-phosphate + D-myo-inositol 1,2-bisphosphate + L-myo-inositol 1,2-bis phosphate + L-myo-inositol 1,2,3,4-tetrakisphosphate + phosphate
show the reaction diagram
-
inositol hexakisphosphate + H2O = inositol pentakisphosphate + phosphate
show the reaction diagram
-
diphosphoinositol pentakisphosphate + H2O = inositol pentakisphosphate + phosphate
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition
-
IC50 for inositol hexakisphosphate kinase activity is 0.022 mM, IC50 for ATP synthase activity is 0.0128 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (6 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (11 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (21 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0055
-
pH 7.0, 37C
0.00004
-
pH 7.4, 37C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.015
-
pH 7.2, 37C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0128
-
IC50 for inositol hexakisphosphate kinase activity is 0.022 mM, IC50 for ATP synthase activity is 0.0128 mM

References & Links

Links to other databases for myo-inositol 1,3,4,5,6-pentakisphosphate

ChEBI
PubChem
ChEBI
PubChem