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1-lauroyl-2-(1'-pyrenebutyroyl)-sn-glycero-3-phosphocholine/in
1-lauroyl-2-(1'-pyrenebutyroyl)-sn-glycero-3-phosphocholine/out
-
i.e. pyrene-10-PC, development of a transbilayer lipid flip-flop assay in PLS3 proteoliposomes, overview
-
-
r
1D-myo-inositol 1-O-myristoyl-2-O-[6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino-hexanoyl]-sn-glycer-3-yl]-phosphate/in
1D-myo-inositol 1-O-myristoyl-2-O-[6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino-hexanoyl]-sn-glycer-3-yl]-phosphate/out
-
fluorescence-labeled substrate, proteoliposomes generated from flippase-enriched Triton X-100 extract of endoplasmic reticulum or native endoplasmic vesicles, overview
-
-
?
1D-myo-inositol 1-O-[1-[6'-([6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino]-hexanoyl]amino)hexanoyl]-2-O-stearoyl-sn-glycer-3-yl]-phosphate/in
1D-myo-inositol 1-O-[1-[6'-([6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino]-hexanoyl]amino)hexanoyl]-2-O-stearoyl-sn-glycer-3-yl]-phosphate/out
-
fluorescence-labeled substrate, proteoliposomes generated from flippase-enriched Triton X-100 extract of endoplasmic reticulum or native endoplasmic vesicles, overview
-
-
?
1D-myo-inositol 3-O-myristoyl-2-O-[6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino-hexanoyl]-sn-glycer-1-yl]-phosphate/in
1D-myo-inositol 3-O-myristoyl-2-O-[6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino-hexanoyl]-sn-glycer-1-yl]-phosphate/out
-
fluorescence-labeled substrate, proteoliposomes generated from flippase-enriched Triton X-100 extract of endoplasmic reticulum or native endoplasmic vesicles, overview
-
-
?
1D-myo-inositol 3-O-[1-[6'-([6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino]-hexanoyl]amino)hexanoyl]-2-O-stearoyl-sn-glycer-1-yl]-phosphate/in
1D-myo-inositol 3-O-[1-[6'-([6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino]-hexanoyl]amino)hexanoyl]-2-O-stearoyl-sn-glycer-1-yl]-phosphate/out
-
fluorescence-labeled substrate, proteoliposomes generated from flippase-enriched Triton X-100 extract of endoplasmic reticulum or native endoplasmic vesicles, overview
-
-
?
1L-myo-inositol 1-O-[1-[6'-([6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino]-hexanoyl]amino)hexanoyl]-2-O-stearoyl-sn-glycer-3-yl]-phosphate/in
1L-myo-inositol 1-O-[1-[6'-([6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino]-hexanoyl]amino)hexanoyl]-2-O-stearoyl-sn-glycer-3-yl]-phosphate/out
-
fluorescence-labeled substrate, proteoliposomes generated from flippase-enriched Triton X-100 extract of endoplasmic reticulum or native endoplasmic vesicles, overview
-
-
?
1L-myo-inositol 3-O-[1-[6'-([6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino]-hexanoyl]amino)hexanoyl]-2-O-stearoyl-sn-glycer-1-yl]-phosphate/in
1L-myo-inositol 3-O-[1-[6'-([6-[(7-nitro-2-oxa-1,3-diazolobenz-4-yl)amino]-hexanoyl]amino)hexanoyl]-2-O-stearoyl-sn-glycer-1-yl]-phosphate/out
-
fluorescence-labeled substrate, proteoliposomes generated from flippase-enriched Triton X-100 extract of endoplasmic reticulum or native endoplasmic vesicles, overview
-
-
?
acetyl phosphate + H2O
acetate + phosphate
-
translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts
-
-
?
ATP + H2O
ADP + phosphate
ATP + H2O + 1-oleoyl-2-[6-(7-nitrol-2-1,3-benzonadiol-4-yl)amino]-sn-glycerophosphocholine/out
ADP + phosphate + 1-oleoyl-2-[6-(7-nitrol-2-1,3-benzonadiol-4-yl)amino]-sn-glycerophosphocholine/in
-
-
-
-
?
ATP + H2O + 1-oleoyl-2-[6-(7-nitrol-2-1,3-benzonadiol-4-yl)amino]-sn-glycerophosphoethanolamine/out
ADP + phosphate + 1-oleoyl-2-[6-(7-nitrol-2-1,3-benzonadiol-4-yl)amino]-sn-glycerophosphoethanolamine/in
-
-
-
-
?
ATP + H2O + 1-oleoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphoserine[side 1]
ADP + phosphate + 1-oleoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphoserine[side 2]
-
-
-
-
?
ATP + H2O + 1-palmitoyl-2-(6-(7-nitro-2-1,3-benzoxadiazole)-aminocaproyl)-phosphatidylcholine/out
ADP + phosphate + 1-palmitoyl-2-(6-(7-nitro-2-1,3-benzoxadiazole)-aminocaproyl)-phosphatidylcholine/in
-
internalization through the plasma membrane by the Dnf1p-Lem3p complex
-
-
?
ATP + H2O + 1-palmitoyl-2-(6-(7-nitro-2-1,3-benzoxadiazole)-aminocaproyl)-phosphatidylethanolamine/out
ADP + phosphate + 1-palmitoyl-2-(6-(7-nitro-2-1,3-benzoxadiazole)-aminocaproyl)-phosphatidylethanolamine/in
-
internalization through the plasma membrane by the Dnf1p-Lem3p complex
-
-
?
ATP + H2O + 1-palmitoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phospho-L-serine/in
ADP + phosphate + 1-palmitoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phospho-L-serine/out
-
-
-
?
ATP + H2O + 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine/in
ADP + phosphate + 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine/out
ATP + H2O + aminophospholipid[side 1]
ADP + phosphate + aminophospholipid[side 2]
-
-
-
-
?
ATP + H2O + asolectin/out
ADP + phosphate + asolectin/in
-
-
-
-
?
ATP + H2O + carboxyfluoresceinyl-phosphatidylserine/in
ADP + phosphate + carboxyfluoresceinyl-phosphatidylserine/out
ATP + H2O + cholera toxin/in
ADP + phosphate + cholera toxin/out
-
through ATP hydrolysis and an interaction with the cytoplasmic membrane protein EpsL, EpsE supports secretion of cholera toxin across the outer membrane
-
-
?
ATP + H2O + coumaryl-phosphatidylserine/in
ADP + phosphate + coumaryl-phosphatidylserine/out
ATP + H2O + galactocerebroside/out
ADP + phosphate + galactocerebroside/in
-
-
-
-
?
ATP + H2O + glycerophospholipid[side 1]
ADP + phosphate + glycerophospholipid[side 2]
-
-
-
-
?
ATP + H2O + H33342/out
ADP + phosphate + H33342/in
-
-
-
-
?
ATP + H2O + lactocerebroside/out
ADP + phosphate + lactocerebroside/in
-
-
-
-
?
ATP + H2O + Lipid A/in
ADP + phosphate + Lipid A/out
-
-
-
?
ATP + H2O + lysophosphatidylcholine/out
ADP + phosphate + lysophosphatidylcholine/in
-
lysophosphatidylcholine is a bona fide biological substrate transported by the yeast plasma membrane ATPases, Dnf1p and Dnf2p, in consort with a second protein Lem3p
-
-
?
ATP + H2O + lysophosphatidylethanolamine/out
ADP + phosphate + lysophosphatidylethanolamine/in
-
lysophosphatidylethanolamine is a bona fide biological substrate transported by the yeast plasma membrane ATPases, Dnf1p and Dnf2p, in consort with a second protein Lem3p
-
-
?
ATP + H2O + miltefosine/in
ADP + phosphate + miltefosine/out
ATP + H2O + miltefosine[side 1]
ADP + phosphate + miltefosine[side 2]
-
-
-
-
?
ATP + H2O + N-methyl-dilauroylphosphatidyl-DL-serine/out
ADP + phosphate + N-methyl-dilauroylphosphatidyl-DL-serine/in
-
rapid change of cell morphology from echinocyte to stomatocyte
-
-
?
ATP + H2O + phosphatidylcholine/in
ADP + phosphate + phosphatidylcholine/out
ATP + H2O + phosphatidylcholine/out
ADP + phosphate + phosphatidylcholine/in
-
-
-
-
?
ATP + H2O + phosphatidylcholine[side 1]
ADP + phosphate + phosphatidylcholine[side 2]
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
ATP + H2O + phosphatidylethanolamine[side 1]
ADP + phosphate + phosphatidylethanolamine[side 2]
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
ATP + H2O + phosphoethanolamine/in
ADP + phosphate + phosphoethanolamine/out
-
low activity
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
ATP + H2O + rhodamine 123/out
ADP + phosphate + rhodamine 123/in
-
-
-
-
?
ATP + H2O + sn-1,2-dilauroylphosphatidyl-D-serine/out
ADP + phosphate + sn-1,2-dilauroylphosphatidyl-D-serine/in
-
rapid change of cell morphology from echinocyte to stomatocyte
-
-
?
ATP + H2O + sn-1,2-dilauroylphosphatidyl-L-serine/out
ADP + phosphate + sn-1,2-dilauroylphosphatidyl-L-serine/in
-
rapid change of cell morphology from echinocyte to stomatocyte
-
-
?
ATP + H2O + sn-2,3-dilauroylphosphatidyl-L-serine/out
ADP + phosphate + sn-2,3-dilauroylphosphatidyl-L-serine/in
-
low activity, slow change of cell morphology from echinocyte to stomatocyte
-
-
?
ATP + H2O + sphingomyelin/out
ADP + phosphate + sphingomyelin/in
-
-
-
-
?
ATP + H2O + sphingomyelin[side 1]
ADP + phosphate + sphingomyelin[side 2]
-
low activity
-
-
?
ATP + H2O + tetramethylrosamine/out
ADP + phosphate + tetramethylrosamine/in
-
-
-
-
?
ATP + H2O + verapamil/out
ADP + phosphate + verapamil/in
-
highest activity
-
-
?
ATP + phospholipid/out
ADP + phosphate + phospholipid/in
di-C4-phosphatidylcholine/out
di-C4-phosphatidylcholine/in
fluorescent labeled phosphatidylserine/outer leaflet + ATP + H2O
fluorescent labeled phosphatidylserine/inner leaflet + ADP + phosphate
-
enzyme specifically transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane
-
-
?
GTP + H2O
GDP + phosphate
-
at 2 mM, 40% of the activity with 2 mM ATP
-
-
?
long-chain phospholipid/out
long-chain phospholipid/in
Man5GlcNAc2-diphosphate-dolichol/out
Man5GlcNAc2-diphosphate-dolichol/in
O-[[(2R)-2-[(9-[5-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-1H-1,2,3-triazol-4-yl]nonanoyl)oxy]-3-(hexadecanoyloxy)propoxy](hydroxy)phosphoryl]-L-serine/outer leaflet + ?
O-[[(2R)-2-[(9-[5-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-1H-1,2,3-triazol-4-yl]nonanoyl)oxy]-3-(hexadecanoyloxy)propoxy](hydroxy)phosphoryl]-L-serine/cytoplasmic leaflet + ?
-
coumarin-derivative of phosphatidylserine
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts
-
-
?
peptidoglycan lipid II/out
peptidoglycan lipid II/in
-
-
-
-
?
phosphatidylcholine/in
phosphatidylcholine/out
-
proteoliposomes generated from aminophospholipid translocase-enriched Triton X-100 extract of endoplasmic reticulum
-
-
?
phosphatidylcholine/out
phosphatidylcholine/in
phosphatidylethanolamine/in
phosphatidylethanolemine/out
-
proteoliposomes generated from aminophospholipid translocase-enriched Triton X-100 extract of endoplasmic reticulum
-
-
?
phosphatidylethanolamine/out
phosphatidylethanolamine/in
phosphatidylserine/in
phosphatidylserine/out
phosphatidylserine/out
phosphatidylserine/in
phospholipid/in
phospholipid/out
additional information
?
-
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
-
?
ATP + H2O
ADP + phosphate
phosphatidylserine is essential for the dephosphorylation of the phosphoenzyme intermediate
-
?
ATP + H2O
ADP + phosphate
-
down-regulation of the aminophospholipid translocase activity is an early step in the programmed cell death in lymphocytes, a step that contributes to the appearance of phosphatidylserine on the cell surface as a recognition signal for phagocytosis
-
-
?
ATP + H2O
ADP + phosphate
the enzyme plays an important role in the maintenance of membrane phospholipid asymmetry, observed in plasma membrane and membranes of certain cellular organelles
-
-
?
ATP + H2O
ADP + phosphate
phosphatidylserine is essential for the dephosphorylation of the phosphoenzyme intermediate. Without phosphatidylserine, ATPase II accumulates as phosphoenzyme in the presence of ATP, resulting in the interruption of its catalytic cycle
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
the stoichiometry between lipid translocation and ATP consumption is 1.13 for phosphatidylserine and 1.11 for phosphatidylethanolamine
-
?
ATP + H2O
ADP + phosphate
-
translocation of the aminophospholipids, phosphatidylserine and phosphatidylethanolamine, from the outer leaflet to the inner leaflet of the lipid bilayer, enzyme is involved in ATP-dependent erythrocyte shape change
-
?
ATP + H2O
ADP + phosphate
-
transport of ethanolamine at a rate 10fold slower than phosphatidylserine
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
?
ATP + H2O
ADP + phosphate
-
transport of phosphatidylserine
-
?
ATP + H2O
ADP + phosphate
-
transport of phosphatidylserine
-
?
ATP + H2O
ADP + phosphate
-
transport of phosphatidylserine
-
?
ATP + H2O
ADP + phosphate
-
the protein serves primarily to prevent the accumulation of phosphatidylserine on the outer surface of the cell
-
?
ATP + H2O
ADP + phosphate
-
transport of a spin-labeled phosphatidylserine analogue from the inner to the outer membrane leaflet provided Mg2+-ATP is present. The ATP-dependent transport of the phosphatidylethanolamine analogue requires the presence of an anionic phospholipid, e.g. phosphatidylinositol in the outer leaflet
-
?
ATP + H2O
ADP + phosphate
-
translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts
-
?
ATP + H2O
ADP + phosphate
-
activity is stimulated twofold by addition of 2 mM ATP
-
?
ATP + H2O
ADP + phosphate
-
ATPase activity is stimulated by phosphatidylserine but not by phosphatidylcholine
-
?
ATP + H2O
ADP + phosphate
-
transport of N-methylphosphatidylserine
-
?
ATP + H2O
ADP + phosphate
-
transport of phosphatidylethanolamine
-
?
ATP + H2O
ADP + phosphate
-
a decrease in the size of the pool of flippase transportable phosphatidylethanolamine molecules causes a corresponding decrease in Mg2+-ATPase activity
-
?
ATP + H2O
ADP + phosphate
-
the initial maintenance of phospholipid asymmetry in diamide-treated erythrocytes can be solely ascribed to the action of the ATP-dependent aminophospholipid translocase
-
-
?
ATP + H2O
ADP + phosphate
-
role in aminophospholipid transport
-
-
?
ATP + H2O
ADP + phosphate
-
role of the enzyme in the control of erythrocyte shape, possibly through association with the ATP-dependent translocation of phosphatidylserine and phosphatidylethanolamine from the outer to the inner leaflet of the bilayer
-
-
?
ATP + H2O
ADP + phosphate
-
the enzyme is responsible for the inward transport of phosphatidylserine and phosphatidylethanolamine within the erythrocyte membrane
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
-
?
ATP + H2O + 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine/in
ADP + phosphate + 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine/out
-
-
-
-
?
ATP + H2O + 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine/in
ADP + phosphate + 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine/out
-
-
-
-
?
ATP + H2O + carboxyfluoresceinyl-phosphatidylserine/in
ADP + phosphate + carboxyfluoresceinyl-phosphatidylserine/out
-
-
-
-
?
ATP + H2O + carboxyfluoresceinyl-phosphatidylserine/in
ADP + phosphate + carboxyfluoresceinyl-phosphatidylserine/out
-
-
-
-
?
ATP + H2O + coumaryl-phosphatidylserine/in
ADP + phosphate + coumaryl-phosphatidylserine/out
-
-
-
-
?
ATP + H2O + coumaryl-phosphatidylserine/in
ADP + phosphate + coumaryl-phosphatidylserine/out
-
-
-
-
?
ATP + H2O + miltefosine/in
ADP + phosphate + miltefosine/out
-
-
-
-
?
ATP + H2O + miltefosine/in
ADP + phosphate + miltefosine/out
-
LdMT and LdRos3 form part of the same translocation machinery that determines flippase activity and miltefosine sensitivity in Leishmania
-
-
?
ATP + H2O + phosphatidylcholine/in
ADP + phosphate + phosphatidylcholine/out
-
-
-
?
ATP + H2O + phosphatidylcholine/in
ADP + phosphate + phosphatidylcholine/out
-
-
-
?
ATP + H2O + phosphatidylcholine/in
ADP + phosphate + phosphatidylcholine/out
preferred substrate
-
-
?
ATP + H2O + phosphatidylcholine/in
ADP + phosphate + phosphatidylcholine/out
-
-
-
?
ATP + H2O + phosphatidylcholine/in
ADP + phosphate + phosphatidylcholine/out
-
palmitoyl-(NBD-hexanoyl)-PC , selective ATP-dependent transport/flip of phosphatidylethanolamine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylcholine/in
ADP + phosphate + phosphatidylcholine/out
preferred substrate of Dnf1
-
-
?
ATP + H2O + phosphatidylcholine[side 1]
ADP + phosphate + phosphatidylcholine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylcholine[side 1]
ADP + phosphate + phosphatidylcholine[side 2]
-
-
-
?
ATP + H2O + phosphatidylcholine[side 1]
ADP + phosphate + phosphatidylcholine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylcholine[side 1]
ADP + phosphate + phosphatidylcholine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylcholine[side 1]
ADP + phosphate + phosphatidylcholine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
the enzyme is specific for ATP and shows no activity with GTP, AMP-PNP, GDP, or ADP
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
selective ATP-dependent transport/flip of phosphatidylethanolamine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
palmitoyl-(NBD-hexanoyl)-PE , selective ATP-dependent transport/flip of phosphatidylethanolamine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
selective ATP-dependent transport/flip of phosphatidylethanolamine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
palmitoyl-(NBD-hexanoyl)-PE , selective ATP-dependent transport/flip of phosphatidylethanolamine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
low activity, transport from the outer to the inner leaflet of the plasma membrane, the activity is regulated by Fas-, caspase 8-, and caspase 3-dependent signaling in erythrocytes with differences in old and young red blood cells, overview
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
low activity, transport from the outer to the inner leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
-
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the luminal leaflet of the membrane to the cytosolic leaflet
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the luminal leaflet of the membrane to the cytosolic leaflet
-
-
?
ATP + H2O + phosphatidylethanolamine[side 1]
ADP + phosphate + phosphatidylethanolamine[side 2]
-
-
-
?
ATP + H2O + phosphatidylethanolamine[side 1]
ADP + phosphate + phosphatidylethanolamine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylethanolamine[side 1]
ADP + phosphate + phosphatidylethanolamine[side 2]
-
-
-
?
ATP + H2O + phosphatidylethanolamine[side 1]
ADP + phosphate + phosphatidylethanolamine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylethanolamine[side 1]
ADP + phosphate + phosphatidylethanolamine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
the enzyme is specific for ATP and shows no activity with GTP, AMP-PNP, GDP, or ADP
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
ABCB4 mediates the efflux of phospholipids into the canalicular lumen in the presence of bile salts, and plays a crucial role in bile formation and lipid homeostasis
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the membrane
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the plasma membrane of erythrocytes to maintainthe lipid asymmetry, overview
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the plasma membrane, proteins are pivotal factors in the trafficking of ATP8B1 to the plasma membrane and thus may be essential determinants of ATP8B1-related disease
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
ABCB4 is required for ATP-dependent phosphatidylcholine secretion into the bile and to translocate phosphatidylcholine across the plasma membrane, overview
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry in the plasma membrane and secretory vesicles
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane, exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
leading to reversible exposure on in the outer plasma membrane leaflet on the cell surface of cardiomyocytes by a flip-flop mechanism
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport/flip of phosphatidylserine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
palmitoyl-(NBD-hexanoyl)-PS , selective ATP-dependent transport/flip of phosphatidylserine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
preferred substrate of Drs2
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport/flip of phosphatidylserine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane, and from the lumenal side of granules to the external side
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
flippase activity: transport from the outer to the inner leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the external leaflet of the membrane to the inner leaflet, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the scramblase activity, overview
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the outer to the inner leaflet of the plasma membrane, the activity is regulated by Fas-, caspase 8-, and caspase 3-dependent signaling in erythrocytes with differences in old and young red blood cells, overview
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the external leaflet of the membrane to the inner leaflet
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the outer to the inner leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
-
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the luminal leaflet of the membrane to the cytosolic leaflet
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the luminal leaflet of the membrane to the cytosolic leaflet
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
very low activity
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
LdMT Is required but not sufficient for the inward-directed translocation activity of phospholipids and miltefosine across the plasma membrane, LdRos3 is additionally required
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
-
ir
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
Dnf1p and Dnf2p are necessary for the internalization phospholipids across the plasma membrane of Saccharomyces cerevisiae, overview. ATP hydrolysis is not sufficient for phospholipid flip in the absence of the proton electrochemical gradient across the plasma membrane, the proton electrochemical gradient is required for phospholipid flip across the plasma membrane of yeast
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
P4-ATPases Drs2p and Dnf1p cycle between the exocytic and endocytic pathways, and maintain a steady-state localization to internal organelles requiring endocytosis signals, Drs2p is an essential endocytic cargo in cells compromised for Ub-dependent endocytosis
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
phospholipid translocases are involved in the generation of phospholipid asymmetry in membrane bilayers
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
the enzyme is involved in protein trafficking, Drs2p acts in complex with the allelic CDC50 protein in ATP-dependent phosphatidylserine translocation playing a role in restricting the substrate to the cytosolic leaflet of the Golgi and the plasma membrane, overview
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
transbilayer movement of phospholipids in an unidirectional fashion in biological membranes is mediated by energy-dependent and energy-independent flippases
-
-
ir
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
ATP-dependent transport of phospholipids from outer to the inner monolayer of the cell membrane to maintain lipid asymmetry, the C-terminal and N-terminal NPFXD motifs ar functionally required by Drs2p and Drf1p, respectively, overview
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
ATP-dependent transport of phospholipids from outer to the inner monolayer of the cell membrane to maintain lipid asymmetry, usage of fluorescent labeled 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled, NBD-labeled, phospholipid substrate. ATP hydrolysis is not sufficient for phospholipid flip in the absence of the proton electrochemical gradient across the plasma membrane, the proton electrochemical gradient is required for phospholipid flip across the plasma membrane of yeast
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
the enzyme is involved in protein trafficking, Drs2p acts in complex with the allelic CDC50 protein in ATP-dependent phosphatidylserine translocation playing a role in restricting the substrate to the cytosolic leaflet of the Golgi and the plasma membrane, overview
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
Dnf1p and Dnf2p are necessary for the internalization phospholipids across the plasma membrane of Saccharomyces cerevisiae, overview. ATP hydrolysis is not sufficient for phospholipid flip in the absence of the proton electrochemical gradient across the plasma membrane, the proton electrochemical gradient is required for phospholipid flip across the plasma membrane of yeast
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
ATP-dependent transport of phospholipids from outer to the inner monolayer of the cell membrane to maintain lipid asymmetry, usage of fluorescent labeled 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled, NBD-labeled, phospholipid substrate. ATP hydrolysis is not sufficient for phospholipid flip in the absence of the proton electrochemical gradient across the plasma membrane, the proton electrochemical gradient is required for phospholipid flip across the plasma membrane of yeast
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
-
ir
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
transbilayer movement of phospholipids in an unidirectional fashion in biological membranes is mediated by energy-dependent and energy-independent flippases
-
-
ir
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
-
?
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
-
?
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
?
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
-
?
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
-
?
ATP + phospholipid/out
ADP + phosphate + phospholipid/in
-
-
-
-
?
ATP + phospholipid/out
ADP + phosphate + phospholipid/in
-
-
-
-
?
ATP + phospholipid/out
ADP + phosphate + phospholipid/in
-
-
-
-
?
ATP + phospholipid/out
ADP + phosphate + phospholipid/in
-
the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane
-
-
?
dATP + H2O
dADP + H2O
-
-
-
-
?
dATP + H2O
dADP + H2O
-
at 2 mM nearly as active as ATP
-
-
?
di-C4-phosphatidylcholine/out
di-C4-phosphatidylcholine/in
-
labeled model substrate
-
-
?
di-C4-phosphatidylcholine/out
di-C4-phosphatidylcholine/in
-
labeled model substrate
-
-
?
long-chain phospholipid/out
long-chain phospholipid/in
-
-
-
-
?
long-chain phospholipid/out
long-chain phospholipid/in
-
-
-
-
?
long-chain phospholipid/out
long-chain phospholipid/in
-
-
-
-
?
Man5GlcNAc2-diphosphate-dolichol/out
Man5GlcNAc2-diphosphate-dolichol/in
-
ATP-independent flipping
-
-
?
Man5GlcNAc2-diphosphate-dolichol/out
Man5GlcNAc2-diphosphate-dolichol/in
-
-
-
-
?
Man5GlcNAc2-diphosphate-dolichol/out
Man5GlcNAc2-diphosphate-dolichol/in
-
-
-
-
?
phosphatidylcholine/out
phosphatidylcholine/in
-
spin-labeled substrate, inward and outward movements, flip and flop, proceed in thermodynamic equilibrium in disc membrane vesicles between inner and out leaflets
-
-
r
phosphatidylcholine/out
phosphatidylcholine/in
-
-
-
-
?
phosphatidylcholine/out
phosphatidylcholine/in
-
L-alpha-1-palmitoyl-2-linoleoyl-labeled substrate
-
-
?
phosphatidylethanolamine/out
phosphatidylethanolamine/in
-
spin-labeled substrate, inward and outward movements, flip and flop, proceed in thermodynamic equilibrium in disc membrane vesicles between inner and out leaflets
-
-
r
phosphatidylethanolamine/out
phosphatidylethanolamine/in
-
-
-
-
?
phosphatidylserine/in
phosphatidylserine/out
-
-
-
-
?
phosphatidylserine/in
phosphatidylserine/out
-
proteoliposomes generated from aminophospholipid translocase-enriched Triton X-100 extract of endoplasmic reticulum
-
-
?
phosphatidylserine/out
phosphatidylserine/in
-
spin-labeled substrate, inward and outward movements, flip and flop, proceed in thermodynamic equilibrium in disc membrane vesicles between inner and out leaflets
-
-
r
phosphatidylserine/out
phosphatidylserine/in
-
bidirectional transport, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the aminophospholipid translocase activity, overview
-
-
r
phosphatidylserine/out
phosphatidylserine/in
-
7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, bidirectional transport
-
-
r
phospholipid/in
phospholipid/out
-
unspecific bidirectional transmembrane transport of phospholipids
-
-
r
phospholipid/in
phospholipid/out
-
-
-
-
?
phospholipid/in
phospholipid/out
-
unspecific bidirectional transmembrane transport of phospholipids
-
-
r
phospholipid/in
phospholipid/out
-
-
-
-
ir
phospholipid/in
phospholipid/out
-
transbilayer movement of phospholipids in an unidirectional fashion in biological membranes is mediated by energy-dependent and energy-independent flippases
-
-
ir
phospholipid/in
phospholipid/out
-
-
-
-
ir
phospholipid/in
phospholipid/out
-
transbilayer movement of phospholipids in an unidirectional fashion in biological membranes is mediated by energy-dependent and energy-independent flippases
-
-
ir
additional information
?
-
-
phospholipids are synthesized on the inner leaflet of the cytoplasmic membrane in bacteria and must translocate to the outer leaflet to propagate a bilayer, transbilayer movement of phospholipids has been shown to be fast and independent of metabolic energy, and it is facilitated by membrane flippases, transport across protein-free membranes is negligible
-
-
?
additional information
?
-
-
the enzyme does not require energy supply for activity
-
-
?
additional information
?
-
-
phospholipids are synthesized on the inner leaflet of the cytoplasmic membrane in bacteria and must translocate to the outer leaflet to propagate a bilayer, transbilayer movement of phospholipids has been shown to be fast and independent of metabolic energy, and it is facilitated by membrane flippases, transport across protein-free membranes is negligible
-
-
?
additional information
?
-
-
the enzyme does not require energy supply for activity
-
-
?
additional information
?
-
-
the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane
-
-
?
additional information
?
-
-
the enzyme depends on ATP
-
-
?
additional information
?
-
Atp8a2 flipps fluorescent-labeled phosphatidylserine from the inner leaflet of liposomes, equivalent to the exocytoplasmic leaflet of cell membranes, to the outer leaflet, equivalent to cytoplasmic leaflet, in an ATP-dependent manner
-
-
?
additional information
?
-
dithionite NBD-lipid assay for detection of flippase activity
-
-
?
additional information
?
-
during the transport across the membrane, the phosphatidylserine head group passes near residue I364. I364 is critical to the release of the transported lipid into the cytosolic leaflet. Transmembrane segment M4 residue N359 is involved in recognition of the lipid substrate on the exoplasmic side. Residue I364 and adjacent hydrophobic residues function as a hydrophobic gate that separates the entry and exit sites of the lipid and directs sequential formation and annihilation of water-filled cavities, thereby enabling transport of the hydrophilic phospholipid head group in a groove outlined by the transmembrane segments M1, M2, M4, and M6, with the hydrocarbon chains following passively, still in the membrane lipid phase
-
-
?
additional information
?
-
-
no transport activity with phosphatidylinositol
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface across the plasma membrane bilayer, which is a conserved event in apoptosis and plays an important role in promoting the clearance of apoptotic cells by phagocytosis, overview
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface of apoptotic germ cells, a conserved event in worms, after activation by WAH-1, a mitochondrially released apoptotic factor, overview
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, scramblase catalyzes the externalization of phosphatidylserine to the cell surface, although PLSCR1 is neither sufficient nor necessary for the phosphatidylserine externalization
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface across the plasma membrane bilayer, overview
-
-
?
additional information
?
-
Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans
-
-
?
additional information
?
-
-
Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans
-
-
?
additional information
?
-
-
the enzyme does not translocalize 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylcholine or coumaryl-phosphatidylcholine
-
-
?
additional information
?
-
-
phosphatidylserine derivatives, with either a neutral 7-nitrobenz-2-oxa-1,3-diazol-4-yl or a coumarin fluorophore appended to the 2-acyl chain, are translocated by aminophospholipid flippase. A phosphatidylserine conjugate containing a charged and polar carboxyfluorescein is not translocated and remains in the cell plasma membrane
-
-
?
additional information
?
-
-
MurJ is required for peptidoglycan biogenesis in Eschrichia coli
-
-
?
additional information
?
-
-
flippase recognizes multiple structural elements in its preferred lipid substrate. The lipid structural elements include a primary amine group, limited headgroup size and and sn-1,2-glycerol backbone. The presence of carboxyl group accelerates transport, but is not required for activity
-
-
?
additional information
?
-
-
the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane
-
-
?
additional information
?
-
-
the enzyme depends on ATP
-
-
?
additional information
?
-
-
the enzyme depends on ATP
-
-
?
additional information
?
-
-
the enzyme does not require energy supply by ATP hydrolysis
-
-
?
additional information
?
-
-
the enzyme is independent of ATP
-
-
?
additional information
?
-
-
the enzyme is independent of ATP or energy supply
-
-
?
additional information
?
-
-
glycoprotein IIb/IIIa blockade inhibits platelet aminophospholipid exposure by potentiating translocase and attenuating scramblase activity, regulation and physiological effects, overview
-
-
?
additional information
?
-
-
phospholipid scramblase 3 is involved in the regulation of tumor necrosis factor-alpha-induced apoptosis, overexpression of PLS3 enhances, whereas downregulation of PLS3 delays, TNF-R-induced apoptosis and targeting of tBid to mitochondria, as well as overexpression increases and downregulation decreases the percentage of cardiolipin on the mitochondrial surface and tBid binding capacity, overview. PLS3 is an important downstream effector of Bcl-2 and tBid in apoptosis,PLS3 regulation, overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
-
PLSCR1 is involved in phosphatidylserine externalization across the plasma membrane, the recombinant PLSCR1 stimulates the decatenation activity of DNA topoisomerase II isozyme alpha, overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells. It plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview. PLSCR3 is involved in regulation of de novo biosynthesis and resynthesis of cardiolipin in mitochondria transporting the lipid from the inner membrane to the outer mitochondrial membrane, phosphorylated PLSCR3 facilitates mitochondrial targeting of t-Bid that is an essential requirement in caspase-8 mediated apoptosis
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells. It plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview. PLSCR3 is involved in regulation of de novo biosynthesis and resynthesis of cardiolipin in mitochondria transporting the lipid from the inner membrane to the outer mitochondrial membrane, phosphorylated PLSCR3 facilitates mitochondrial targeting of t-Bid that is an essential requirement in caspase-8 mediated apoptosis
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells. It plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview. PLSCR3 is involved in regulation of de novo biosynthesis and resynthesis of cardiolipin in mitochondria transporting the lipid from the inner membrane to the outer mitochondrial membrane, phosphorylated PLSCR3 facilitates mitochondrial targeting of t-Bid that is an essential requirement in caspase-8 mediated apoptosis
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells. It plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview. PLSCR3 is involved in regulation of de novo biosynthesis and resynthesis of cardiolipin in mitochondria transporting the lipid from the inner membrane to the outer mitochondrial membrane, phosphorylated PLSCR3 facilitates mitochondrial targeting of t-Bid that is an essential requirement in caspase-8 mediated apoptosis
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface from the inner leaflet of the plasma membrane, nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment, involved in inflammation, reversible by DTT, overview, macrophages can directly participate in apoptotic cell clearance by S-nitrosylation/oxidation and inhibition of APLT causing PS externalization, reversible by DTT
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface. Activated platelets express a procoagulant surface when the asymmetric distribution of membrane phospholipids is scrambled, leading to phosphatidylserine exposure. Phosphatidylserine expression, associated with apoptosis in nucleated cells, is reversed by APLT activity. Persistence of procoagulant surface expression is due to reduced APLT activity, regulation, overview
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, PLSCR1 is neither sufficient nor necessary for the phosphatidylserine externalization, a 1000fold increase in cytosolic Ca2+ level in response to cell activation, coagulation and apoptotic signal inactivates the ATP transporters and activates the PLSCR. This exposes PS on the cell surface, enabling the engulfment of the cell by the macrophages or binding of prothrombinase complex to activate blood coagulation cascade
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, PLSCR1 is neither sufficient nor necessary for the phosphatidylserine externalization, a 1000fold increase in cytosolic Ca2+ level in response to cell activation, coagulation and apoptotic signal inactivates the ATP transporters and activates the PLSCR. This exposes PS on the cell surface, enabling the engulfment of the cell by the macrophages or binding of prothrombinase complex to activate blood coagulation cascade
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, PLSCR1 is neither sufficient nor necessary for the phosphatidylserine externalization, a 1000fold increase in cytosolic Ca2+ level in response to cell activation, coagulation and apoptotic signal inactivates the ATP transporters and activates the PLSCR. This exposes PS on the cell surface, enabling the engulfment of the cell by the macrophages or binding of prothrombinase complex to activate blood coagulation cascade
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, PLSCR1 is neither sufficient nor necessary for the phosphatidylserine externalization, a 1000fold increase in cytosolic Ca2+ level in response to cell activation, coagulation and apoptotic signal inactivates the ATP transporters and activates the PLSCR. This exposes PS on the cell surface, enabling the engulfment of the cell by the macrophages or binding of prothrombinase complex to activate blood coagulation cascade
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, the scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, the scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, the scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, the scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
recombinant ATP8B1 Physically Interacts with HA-CDC50A and HA-CDC50B, uptake of 7-nitro-2-1,3-benzoxadiazol-4-yllabeled phosphatidylcholine, phosphatidylethanolamine and sphingomyelin is not dependent on ATP8B1-CDC50 expression
-
-
?
additional information
?
-
-
substrate specificity, overview, no transport of dilauroylphosphatidylcholine, poor activity with dilauroylphosphatidylhydroxypropionate, dilauroylphosphatidylhomoserine, dilauroylphosphatidylserine-methyl ester, or sn-2,3-dilauroylphosphatidyl-D-serine
-
-
?
additional information
?
-
-
the enzyme interacts with the alpha and beta isozymes of DNA topoisomerase II binding to a specific binding site on the topo isozymes, DNA topoisomerase II isozyme alpha residues 1432-1441 are essential for binding to PLSCR1, the interaction can be inhibited by a synthetic peptide corresponding to DNA topoisomerase II isozyme alpha amino acids 1430-1441, overview
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface from the inner leaflet of the plasma membrane
-
-
?
additional information
?
-
-
phosphatidylcholine, phosphatidylethanolamine, phophatidylserine, triglyceride, and cholesterol are no substrates of P-glycoprotein, ethyl acetate extracts from mouse brain homogenate exhibit weak substrate activity of P-glycoprotein
-
-
?
additional information
?
-
-
aminophospholipid translocase returns externalized phosphatidylserine to the inner membrane
-
-
?
additional information
?
-
Atp8a2 flipps fluorescent-labeled phosphatidylserine from the inner leaflet of liposomes, equivalent to the exocytoplasmic leaflet of cell membranes, to the outer leaflet, equivalent to cytoplasmic leaflet, in an ATP-dependent manner
-
-
?
additional information
?
-
dithionite NBD-lipid assay for detection of flippase activity
-
-
?
additional information
?
-
-
the enzyme does not translocalize 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylcholine or coumaryl-phosphatidylcholine
-
-
?
additional information
?
-
-
usage of 1-palmitoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]caproyl]-sn-glycero-3-phosphatidylserine as transport substrate in assays of translocated from the outer to the inner membrane leaflet
-
-
?
additional information
?
-
no substrates: phosphatidylcholine, sphingomyelin
-
-
?
additional information
?
-
no substrates: phosphatidylcholine, sphingomyelin
-
-
?
additional information
?
-
no substrates: phosphatidylcholine, sphingomyelin
-
-
?
additional information
?
-
no substrates: phosphatidylcholine, sphingomyelin
-
-
?
additional information
?
-
-
no substrates: phosphatidylcholine, sphingomyelin
-
-
?
additional information
?
-
-
the enzyme is directly involved in miltefosine uptake in eukaryotic cells
-
-
?
additional information
?
-
-
the enzyme is able to promote the translocalisation of aminophospholipids and glycerophosphocholine molecules such as NBD-phosphatidylcholine and edelfosine and non glycerol based alkylphosphocholine miltefosin
-
-
?
additional information
?
-
-
the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane
-
-
?
additional information
?
-
-
the enzyme depends on ATP
-
-
?
additional information
?
-
-
the membrane lipid bilayer asymmetry is maintained by the enzyme
-
-
?
additional information
?
-
-
the lipid flippase activity of enzyme is associated with its drug transport function
-
-
?
additional information
?
-
-
the enzyme translocates phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, PLSCR1 is neither sufficient nor necessary for the phosphatidylserine externalization
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, PLSCR1 is neither sufficient nor necessary for the phosphatidylserine externalization
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, the scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
calcium-induced phospholipid scrambling is bidirectional, reversible and insensitive to phospholipid head group, the scramblase catalyzes the externalization of phosphatidylserine to the cell surface
-
-
?
additional information
?
-
ATP8B3 may play a role in acrosome development and/or in sperm function during fertilization
-
-
?
additional information
?
-
-
ATP8B3 may play a role in acrosome development and/or in sperm function during fertilization
-
-
?
additional information
?
-
Atp8a2 flipps fluorescent-labeled phosphatidylserine from the inner leaflet of liposomes, equivalent to the exocytoplasmic leaflet of cell membranes, to the outer leaflet, equivalent to cytoplasmic leaflet, in an ATP-dependent manner
-
-
?
additional information
?
-
-
the enzyme is a key enzyme of membrane biogenesis performing transbilayer flipping of glycerophospholipids in the endoplasmic reticulum, this flipping is an ATP-independent, bidirectional process
-
-
?
additional information
?
-
-
the enzyme is a key enzyme of membrane biogenesis performing transbilayer flipping of glycerophospholipids, e.g. in the endoplasmic reticulum, flipping is an ATP-independent, bidirectional process
-
-
?
additional information
?
-
-
the enzyme is independent of ATP or energy supply
-
-
?
additional information
?
-
-
The enzyme is essential for inward translocation of NBD-labeled phosphatidylethanolamine, phosphatidylserine and phosphatidylcholine across the plasmamembrane.
-
-
?
additional information
?
-
-
the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane, especially Neo1p is important, Drs2p is involved in vesicle formation in the Golgi and thus influences the plasma membrane distribution of aminophospholipids despite its localization the Golgi membrane, mechanism
-
-
?
additional information
?
-
-
the Lem3p-Dnf1p complex can substitute for the Cdc50p-Drs2p complex, its redundant partner in the endosomal/trans-Golgi network compartments
-
-
?
additional information
?
-
-
Dnf1p forms a complex with Lem3p acting as aminophospholipid translocase
-
-
?
additional information
?
-
-
the enzyme depends on ATP
-
-
?
additional information
?
-
-
endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway, overview. The homologous proteins Cdc50p, Lem3p, and Crf1p are potential noncatalytic subunits of Drs2p, Dnf1p and Dnf2p, and Dnf3p, respectively, these putative heteromeric PLTs share an essential function for cell growth, overview
-
-
?
additional information
?
-
-
functional co-dependence between Drs2p and the AP-1 clathrin adaptor in protein sorting at the trans-Golgi network and early endosomes of Saccharomyces cerevisiae, Drs2p and AP-1 operate in the same pathway and that AP-1 requires Drs2p for function, Drs2p physically interacts with AP-1, overview
-
-
?
additional information
?
-
-
loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles, overview
-
-
?
additional information
?
-
-
Cdc50 family proteins form complexes with Drs2 family proteins, overview
-
-
?
additional information
?
-
-
complex formation of Drs2p with CDC50, overview
-
-
?
additional information
?
-
-
no transport of (NBD-hexanoyl)-sphingosine-1-phosphocholine
-
-
?
additional information
?
-
-
shape change of giant unilamellar vesicles can be used as a tool to study the occurrence and time scale of flippase-mediated transbilayer movement of unlabeled phospholipids, overview
-
-
?
additional information
?
-
-
isozyme Drs2p interacts with the guanine nucleotide exchange factor Gea2p involved in activation of ADP-ribosylation factors
-
-
?
additional information
?
-
-
isozyme Neo1p interacts with the guanine nucleotide exchange factor Ysl2p/Mon2p and the Arf Arl1p, and cooperation between these three proteins is important for recruitment of clathrin adaptors
-
-
?
additional information
?
-
wild type Dnf1 cannot translocate NBD-SM or NBD-PA
-
-
?
additional information
?
-
wild type Dnf1 cannot translocate NBD-SM or NBD-PA
-
-
?
additional information
?
-
-
wild type Dnf1 cannot translocate NBD-SM or NBD-PA
-
-
?
additional information
?
-
-
no activity with phosphatidic acid
-
-
?
additional information
?
-
-
complex formation of Drs2p with CDC50, overview
-
-
?
additional information
?
-
-
loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles, overview
-
-
?
additional information
?
-
-
no transport of (NBD-hexanoyl)-sphingosine-1-phosphocholine
-
-
?
additional information
?
-
-
shape change of giant unilamellar vesicles can be used as a tool to study the occurrence and time scale of flippase-mediated transbilayer movement of unlabeled phospholipids, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + H2O
ADP + phosphate
ATP + H2O + aminophospholipid[side 1]
ADP + phosphate + aminophospholipid[side 2]
-
-
-
-
?
ATP + H2O + glycerophospholipid[side 1]
ADP + phosphate + glycerophospholipid[side 2]
-
-
-
-
?
ATP + H2O + miltefosine/in
ADP + phosphate + miltefosine/out
-
LdMT and LdRos3 form part of the same translocation machinery that determines flippase activity and miltefosine sensitivity in Leishmania
-
-
?
ATP + H2O + phosphatidylcholine[side 1]
ADP + phosphate + phosphatidylcholine[side 2]
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
ATP + H2O + phosphatidylethanolamine[side 1]
ADP + phosphate + phosphatidylethanolamine[side 2]
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
ATP + H2O + phosphoethanolamine/in
ADP + phosphate + phosphoethanolamine/out
-
low activity
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
ATP + phospholipid/out
ADP + phosphate + phospholipid/in
phosphatidylcholine/out
phosphatidylcholine/in
-
-
-
-
?
phosphatidylserine/in
phosphatidylserine/out
-
-
-
-
?
phosphatidylserine/out
phosphatidylserine/in
-
bidirectional transport, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the aminophospholipid translocase activity, overview
-
-
r
phospholipid/in
phospholipid/out
additional information
?
-
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
-
?
ATP + H2O
ADP + phosphate
-
down-regulation of the aminophospholipid translocase activity is an early step in the programmed cell death in lymphocytes, a step that contributes to the appearance of phosphatidylserine on the cell surface as a recognition signal for phagocytosis
-
-
?
ATP + H2O
ADP + phosphate
the enzyme plays an important role in the maintenance of membrane phospholipid asymmetry, observed in plasma membrane and membranes of certain cellular organelles
-
-
?
ATP + H2O
ADP + phosphate
phosphatidylserine is essential for the dephosphorylation of the phosphoenzyme intermediate. Without phosphatidylserine, ATPase II accumulates as phosphoenzyme in the presence of ATP, resulting in the interruption of its catalytic cycle
-
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
-
?
ATP + H2O
ADP + phosphate
-
the initial maintenance of phospholipid asymmetry in diamide-treated erythrocytes can be solely ascribed to the action of the ATP-dependent aminophospholipid translocase
-
-
?
ATP + H2O
ADP + phosphate
-
role in aminophospholipid transport
-
-
?
ATP + H2O
ADP + phosphate
-
role of the enzyme in the control of erythrocyte shape, possibly through association with the ATP-dependent translocation of phosphatidylserine and phosphatidylethanolamine from the outer to the inner leaflet of the bilayer
-
-
?
ATP + H2O
ADP + phosphate
-
the enzyme is responsible for the inward transport of phosphatidylserine and phosphatidylethanolamine within the erythrocyte membrane
-
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
-
?
ATP + H2O
ADP + phosphate
-
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
selective ATP-dependent transport/flip of phosphatidylethanolamine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylethanolamine/in
ADP + phosphate + phosphatidylethanolamine/out
-
selective ATP-dependent transport/flip of phosphatidylethanolamine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
low activity, transport from the outer to the inner leaflet of the plasma membrane, the activity is regulated by Fas-, caspase 8-, and caspase 3-dependent signaling in erythrocytes with differences in old and young red blood cells, overview
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylethanolamine/out
ADP + phosphate + phosphatidylethanolamine/in
-
transport from the luminal leaflet of the membrane to the cytosolic leaflet
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
ABCB4 mediates the efflux of phospholipids into the canalicular lumen in the presence of bile salts, and plays a crucial role in bile formation and lipid homeostasis
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the membrane
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the plasma membrane of erythrocytes to maintainthe lipid asymmetry, overview
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the plasma membrane, proteins are pivotal factors in the trafficking of ATP8B1 to the plasma membrane and thus may be essential determinants of ATP8B1-related disease
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry in the plasma membrane and secretory vesicles
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane, exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
leading to reversible exposure on in the outer plasma membrane leaflet on the cell surface of cardiomyocytes by a flip-flop mechanism
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport/flip of phosphatidylserine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylserine/in
ADP + phosphate + phosphatidylserine/out
-
selective ATP-dependent transport/flip of phosphatidylserine from the outer to the inner monolayer of the cell membrane and post-Golgi secretory vesicles to maintain lipid asymmetry
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
flippase activity: transport from the outer to the inner leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the external leaflet of the membrane to the inner leaflet, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the scramblase activity, overview
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the outer to the inner leaflet of the plasma membrane, the activity is regulated by Fas-, caspase 8-, and caspase 3-dependent signaling in erythrocytes with differences in old and young red blood cells, overview
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the exoplasmic to the cytosolic leaflet of the plasma membrane
-
-
?
ATP + H2O + phosphatidylserine/out
ADP + phosphate + phosphatidylserine/in
-
transport from the luminal leaflet of the membrane to the cytosolic leaflet
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
?
ATP + H2O + phosphatidylserine[side 1]
ADP + phosphate + phosphatidylserine[side 2]
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
LdMT Is required but not sufficient for the inward-directed translocation activity of phospholipids and miltefosine across the plasma membrane, LdRos3 is additionally required
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
-
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
Dnf1p and Dnf2p are necessary for the internalization phospholipids across the plasma membrane of Saccharomyces cerevisiae, overview. ATP hydrolysis is not sufficient for phospholipid flip in the absence of the proton electrochemical gradient across the plasma membrane, the proton electrochemical gradient is required for phospholipid flip across the plasma membrane of yeast
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
P4-ATPases Drs2p and Dnf1p cycle between the exocytic and endocytic pathways, and maintain a steady-state localization to internal organelles requiring endocytosis signals, Drs2p is an essential endocytic cargo in cells compromised for Ub-dependent endocytosis
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
phospholipid translocases are involved in the generation of phospholipid asymmetry in membrane bilayers
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
the enzyme is involved in protein trafficking, Drs2p acts in complex with the allelic CDC50 protein in ATP-dependent phosphatidylserine translocation playing a role in restricting the substrate to the cytosolic leaflet of the Golgi and the plasma membrane, overview
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
transbilayer movement of phospholipids in an unidirectional fashion in biological membranes is mediated by energy-dependent and energy-independent flippases
-
-
ir
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
the enzyme is involved in protein trafficking, Drs2p acts in complex with the allelic CDC50 protein in ATP-dependent phosphatidylserine translocation playing a role in restricting the substrate to the cytosolic leaflet of the Golgi and the plasma membrane, overview
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
Dnf1p and Dnf2p are necessary for the internalization phospholipids across the plasma membrane of Saccharomyces cerevisiae, overview. ATP hydrolysis is not sufficient for phospholipid flip in the absence of the proton electrochemical gradient across the plasma membrane, the proton electrochemical gradient is required for phospholipid flip across the plasma membrane of yeast
-
-
?
ATP + H2O + phospholipid/in
ADP + phosphate + phospholipid/out
-
transbilayer movement of phospholipids in an unidirectional fashion in biological membranes is mediated by energy-dependent and energy-independent flippases
-
-
ir
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
-
?
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
-
?
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
?
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
-
?
ATP + H2O + phospholipid[side 1]
ADP + phosphate + phospholipid[side 2]
-
-
-
-
?
ATP + phospholipid/out
ADP + phosphate + phospholipid/in
-
-
-
-
?
ATP + phospholipid/out
ADP + phosphate + phospholipid/in
-
-
-
-
?
ATP + phospholipid/out
ADP + phosphate + phospholipid/in
-
the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane
-
-
?
phospholipid/in
phospholipid/out
-
unspecific bidirectional transmembrane transport of phospholipids
-
-
r
phospholipid/in
phospholipid/out
-
-
-
-
?
phospholipid/in
phospholipid/out
-
unspecific bidirectional transmembrane transport of phospholipids
-
-
r
phospholipid/in
phospholipid/out
-
transbilayer movement of phospholipids in an unidirectional fashion in biological membranes is mediated by energy-dependent and energy-independent flippases
-
-
ir
phospholipid/in
phospholipid/out
-
transbilayer movement of phospholipids in an unidirectional fashion in biological membranes is mediated by energy-dependent and energy-independent flippases
-
-
ir
additional information
?
-
-
phospholipids are synthesized on the inner leaflet of the cytoplasmic membrane in bacteria and must translocate to the outer leaflet to propagate a bilayer, transbilayer movement of phospholipids has been shown to be fast and independent of metabolic energy, and it is facilitated by membrane flippases, transport across protein-free membranes is negligible
-
-
?
additional information
?
-
-
phospholipids are synthesized on the inner leaflet of the cytoplasmic membrane in bacteria and must translocate to the outer leaflet to propagate a bilayer, transbilayer movement of phospholipids has been shown to be fast and independent of metabolic energy, and it is facilitated by membrane flippases, transport across protein-free membranes is negligible
-
-
?
additional information
?
-
-
the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane
-
-
?
additional information
?
-
Atp8a2 flipps fluorescent-labeled phosphatidylserine from the inner leaflet of liposomes, equivalent to the exocytoplasmic leaflet of cell membranes, to the outer leaflet, equivalent to cytoplasmic leaflet, in an ATP-dependent manner
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface across the plasma membrane bilayer, which is a conserved event in apoptosis and plays an important role in promoting the clearance of apoptotic cells by phagocytosis, overview
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface of apoptotic germ cells, a conserved event in worms, after activation by WAH-1, a mitochondrially released apoptotic factor, overview
-
-
?
additional information
?
-
Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans
-
-
?
additional information
?
-
-
Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans
-
-
?
additional information
?
-
-
MurJ is required for peptidoglycan biogenesis in Eschrichia coli
-
-
?
additional information
?
-
-
the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane
-
-
?
additional information
?
-
-
glycoprotein IIb/IIIa blockade inhibits platelet aminophospholipid exposure by potentiating translocase and attenuating scramblase activity, regulation and physiological effects, overview
-
-
?
additional information
?
-
-
phospholipid scramblase 3 is involved in the regulation of tumor necrosis factor-alpha-induced apoptosis, overexpression of PLS3 enhances, whereas downregulation of PLS3 delays, TNF-R-induced apoptosis and targeting of tBid to mitochondria, as well as overexpression increases and downregulation decreases the percentage of cardiolipin on the mitochondrial surface and tBid binding capacity, overview. PLS3 is an important downstream effector of Bcl-2 and tBid in apoptosis,PLS3 regulation, overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
-
PLSCR1 is involved in phosphatidylserine externalization across the plasma membrane, the recombinant PLSCR1 stimulates the decatenation activity of DNA topoisomerase II isozyme alpha, overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells, redistribution of plasma membrane phospholipids is triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells. It plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview. PLSCR3 is involved in regulation of de novo biosynthesis and resynthesis of cardiolipin in mitochondria transporting the lipid from the inner membrane to the outer mitochondrial membrane, phosphorylated PLSCR3 facilitates mitochondrial targeting of t-Bid that is an essential requirement in caspase-8 mediated apoptosis
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells. It plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview. PLSCR3 is involved in regulation of de novo biosynthesis and resynthesis of cardiolipin in mitochondria transporting the lipid from the inner membrane to the outer mitochondrial membrane, phosphorylated PLSCR3 facilitates mitochondrial targeting of t-Bid that is an essential requirement in caspase-8 mediated apoptosis
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells. It plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview. PLSCR3 is involved in regulation of de novo biosynthesis and resynthesis of cardiolipin in mitochondria transporting the lipid from the inner membrane to the outer mitochondrial membrane, phosphorylated PLSCR3 facilitates mitochondrial targeting of t-Bid that is an essential requirement in caspase-8 mediated apoptosis
-
-
?
additional information
?
-
the enzyme is responsible for maintainance of the asymmetric phospholipid distribution in plasma membranes in apoptotic cells. It plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview. PLSCR3 is involved in regulation of de novo biosynthesis and resynthesis of cardiolipin in mitochondria transporting the lipid from the inner membrane to the outer mitochondrial membrane, phosphorylated PLSCR3 facilitates mitochondrial targeting of t-Bid that is an essential requirement in caspase-8 mediated apoptosis
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface from the inner leaflet of the plasma membrane, nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment, involved in inflammation, reversible by DTT, overview, macrophages can directly participate in apoptotic cell clearance by S-nitrosylation/oxidation and inhibition of APLT causing PS externalization, reversible by DTT
-
-
?
additional information
?
-
-
the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface. Activated platelets express a procoagulant surface when the asymmetric distribution of membrane phospholipids is scrambled, leading to phosphatidylserine exposure. Phosphatidylserine expression, associated with apoptosis in nucleated cells, is reversed by APLT activity. Persistence of procoagulant surface expression is due to reduced APLT activity, regulation, overview
-
-
?
additional information
?
-
-
aminophospholipid translocase returns externalized phosphatidylserine to the inner membrane
-
-
?
additional information
?
-
Atp8a2 flipps fluorescent-labeled phosphatidylserine from the inner leaflet of liposomes, equivalent to the exocytoplasmic leaflet of cell membranes, to the outer leaflet, equivalent to cytoplasmic leaflet, in an ATP-dependent manner
-
-
?
additional information
?
-
-
the enzyme is directly involved in miltefosine uptake in eukaryotic cells
-
-
?
additional information
?
-
-
the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane
-
-
?
additional information
?
-
-
the membrane lipid bilayer asymmetry is maintained by the enzyme
-
-
?
additional information
?
-
-
the lipid flippase activity of enzyme is associated with its drug transport function
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
PLSCR1 acts as signaling molecule and is involved in redistribution of plasma membrane phospholipids triggered by increased cytosolic Ca2+. The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
The enzyme plays a role in apoptosis, lipid metabolism, and thrombosis, and is involved in the Scott syndrome, detailed overview
-
-
?
additional information
?
-
ATP8B3 may play a role in acrosome development and/or in sperm function during fertilization
-
-
?
additional information
?
-
-
ATP8B3 may play a role in acrosome development and/or in sperm function during fertilization
-
-
?
additional information
?
-
Atp8a2 flipps fluorescent-labeled phosphatidylserine from the inner leaflet of liposomes, equivalent to the exocytoplasmic leaflet of cell membranes, to the outer leaflet, equivalent to cytoplasmic leaflet, in an ATP-dependent manner
-
-
?
additional information
?
-
-
the enzyme is a key enzyme of membrane biogenesis performing transbilayer flipping of glycerophospholipids in the endoplasmic reticulum, this flipping is an ATP-independent, bidirectional process
-
-
?
additional information
?
-
-
the enzyme is a key enzyme of membrane biogenesis performing transbilayer flipping of glycerophospholipids, e.g. in the endoplasmic reticulum, flipping is an ATP-independent, bidirectional process
-
-
?
additional information
?
-
-
The enzyme is essential for inward translocation of NBD-labeled phosphatidylethanolamine, phosphatidylserine and phosphatidylcholine across the plasmamembrane.
-
-
?
additional information
?
-
-
the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane, especially Neo1p is important, Drs2p is involved in vesicle formation in the Golgi and thus influences the plasma membrane distribution of aminophospholipids despite its localization the Golgi membrane, mechanism
-
-
?
additional information
?
-
-
the Lem3p-Dnf1p complex can substitute for the Cdc50p-Drs2p complex, its redundant partner in the endosomal/trans-Golgi network compartments
-
-
?
additional information
?
-
-
endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway, overview. The homologous proteins Cdc50p, Lem3p, and Crf1p are potential noncatalytic subunits of Drs2p, Dnf1p and Dnf2p, and Dnf3p, respectively, these putative heteromeric PLTs share an essential function for cell growth, overview
-
-
?
additional information
?
-
-
functional co-dependence between Drs2p and the AP-1 clathrin adaptor in protein sorting at the trans-Golgi network and early endosomes of Saccharomyces cerevisiae, Drs2p and AP-1 operate in the same pathway and that AP-1 requires Drs2p for function, Drs2p physically interacts with AP-1, overview
-
-
?
additional information
?
-
-
loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles, overview
-
-
?
additional information
?
-
-
isozyme Drs2p interacts with the guanine nucleotide exchange factor Gea2p involved in activation of ADP-ribosylation factors
-
-
?
additional information
?
-
-
isozyme Neo1p interacts with the guanine nucleotide exchange factor Ysl2p/Mon2p and the Arf Arl1p, and cooperation between these three proteins is important for recruitment of clathrin adaptors
-
-
?
additional information
?
-
-
loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles, overview
-
-
?
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