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Information on EC 7.4.2.14 - ABC-type antigen peptide transporter

for references in articles please use BRENDA:EC7.4.2.14
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EC Tree
IUBMB Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. This entry describes vertebrate transporters involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with major histocompatibility complex (MHC) class I molecules. The substrates are generated mainly from degradation of cytosolic proteins by the proteasome.
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Word Map
  • 7.4.2.14
  • tapasin
  • proteasome
  • ctl
  • evasion
  • calreticulin
  • tap-deficient
  • i-restricted
  • surveillance
  • beta2-microglobulin
  • erp57
  • tap-independent
  • herpes
  • icp47
  • calnexin
  • peptide-binding
  • herpesvirus
  • antigen-presenting
  • antigen-processing
  • beta2m
  • cross-presentation
  • malignantly
  • hla-b27
  • 2-microglobulin
  • peptide-mhc
  • spondylitis
  • er-resident
  • ankylosing
  • hla-a
  • reticulum-resident
  • cross-present
  • i-deficient
  • allotypes
  • i-specific
  • immunoproteasome
  • self-peptides
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
+
antigen peptide[side 1]
=
+
+
antigen peptide[side 2]
Synonyms
transporter associated with antigen processing, peptide-loading complex, transporter associated with antigen processing 1, tap transporter, tap 1, transporter associated with ag processing, transporter associated with antigen processing 2, peptide pump, peptide supply factor, abc transporter tap, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + antigen peptide[side 1] = ADP + phosphate + antigen peptide[side 2]
show the reaction diagram
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