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Synonyms
tcyabc, l-cystine transporter, cystine importer, fliy-yecsc, l-cystine abc transporter, ytmjklmn, cystine abc transporter, yckkji, tcyabc transporter, tcyjln,
more
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ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
ATP + H2O + diaminopimelate-[diaminopimelate-binding protein](side 1)
ADP + phosphate + diaminopimelate(side 2) + [diaminopimelate-binding protein](side 1)
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-
?
ATP + H2O + L-cystine-[cystine-binding protein II][side 1]
ADP + phosphate + L-cystine[side 2] + [cystine-binding protein II][side 1]
ATP + H2O + L-cystine-[cystine-binding protein I][side 1]
ADP + phosphate + L-cystine[side 2] + [cystine-binding protein I][side 1]
ATP + H2O + L-cystine-[cystine-binding protein Ngo0372](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein Ngo0372](side 1)
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
ATP + H2O + L-cystine-[cystine-binding protein][side 1]
ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1]
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?
ATP + H2O + selenocystine-[cystine-binding protein Ngo0372](side 1)
ADP + phosphate + selenocystine(side 2) + [cystine-binding protein Ngo0372](side 1)
ATP + H2O + selenocystine-[cystine-binding protein](side 1)
ADP + phosphate + selenocystine(side 2) + [cystine-binding protein](side 1)
additional information
?
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ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein II][side 1]
ADP + phosphate + L-cystine[side 2] + [cystine-binding protein II][side 1]
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-
-
-
?
ATP + H2O + L-cystine-[cystine-binding protein II][side 1]
ADP + phosphate + L-cystine[side 2] + [cystine-binding protein II][side 1]
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-
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?
ATP + H2O + L-cystine-[cystine-binding protein I][side 1]
ADP + phosphate + L-cystine[side 2] + [cystine-binding protein I][side 1]
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?
ATP + H2O + L-cystine-[cystine-binding protein I][side 1]
ADP + phosphate + L-cystine[side 2] + [cystine-binding protein I][side 1]
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?
ATP + H2O + L-cystine-[cystine-binding protein Ngo0372](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein Ngo0372](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein Ngo0372](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein Ngo0372](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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-
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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-
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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-
?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + selenocystine-[cystine-binding protein Ngo0372](side 1)
ADP + phosphate + selenocystine(side 2) + [cystine-binding protein Ngo0372](side 1)
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?
ATP + H2O + selenocystine-[cystine-binding protein Ngo0372](side 1)
ADP + phosphate + selenocystine(side 2) + [cystine-binding protein Ngo0372](side 1)
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?
ATP + H2O + selenocystine-[cystine-binding protein](side 1)
ADP + phosphate + selenocystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + selenocystine-[cystine-binding protein](side 1)
ADP + phosphate + selenocystine(side 2) + [cystine-binding protein](side 1)
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?
additional information
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methyl-L-cysteine and L-cysteine are no substrates
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additional information
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methyl-L-cysteine and L-cysteine are no substrates
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
ATP + H2O + L-cystine-[cystine-binding protein][side 1]
ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1]
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?
ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
-
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?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DL-diaminopimelic acid
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enzyme YtmJKLMN shows 39% inhibition at 0.05 mM
DL-homocysteine
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enzyme YtmJKLMN shows 24% inhibition at 0.05 mM
DL-lanthionine
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enzyme YtmJKLMN shows 32% inhibition at 0.05 mM
L-arginine
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enzyme YtmJKLMN shows 28% inhibition at 0.05 mM
L-glutamine
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enzyme YtmJKLMN shows 32% inhibition at 0.05 mM
L-histidine
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enzyme YtmJKLMN shows 45% inhibition at 0.05 mM
L-methionine
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enzyme YtmJKLMN shows 40% inhibition at 0.05 mM
oxidized glutathione
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enzyme YtmJKLMN shows less than 10% inhibition at 0.05 mM
selenocystine
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competitively blocks cystine import by enzyme form YdjN
additional information
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not inhibited by FeSO4, L-arginine, L-glutamine, L-glutamate, L-leucine, and L-methionine
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DL-cystathionine
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enzyme YtmJKLMN shows 80% inhibition at 0.05 mM
DL-cystathionine
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strongly inhibited by DL-cystathionine
L-cysteine
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enzyme YtmJKLMN shows less than 10% inhibition at 0.05 mM
L-cysteine
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moderately inhibited by L-cysteine
L-djenkolic acid
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enzyme YtmJKLMN shows 89% inhibition at 0.05 mM
L-djenkolic acid
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strongly inhibited by L-djenkolic acid
S-methyl-L-cysteine
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enzyme YtmJKLMN shows 73% inhibition at 0.05 mM
S-methyl-L-cysteine
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moderately inhibited by S-methyl-L-cysteine
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Kumar, P.; Kesari, P.; Kokane, S.; Ghosh, D.K.; Kumar, P.; Sharma, A.K.
Crystal structures of a putative periplasmic cystine-binding protein from Candidatus Liberibacter asiaticus insights into an adapted mechanism of ligand binding
FEBS J.
286
3450-3472
2019
Candidatus Liberibacter asiaticus (C6XGT2), Candidatus Liberibacter asiaticus, Candidatus Liberibacter asiaticus psy62 (C6XGT2)
brenda
Kim, J.; Senadheera, D.; Levesque, C.; Cvitkovitch, D.
TcyR regulates L-cystine uptake via the TcyABC transporter in Streptococcus mutans
FEMS Microbiol. Lett.
328
114-121
2012
Streptococcus mutans, Streptococcus mutans UA159
brenda
Burguiere, P.; Auger, S.; Hullo, M.; Danchin, A.; Martin-Verstraete, I.
Three different systems participate in L-cystine uptake in Bacillus subtilis
J. Bacteriol.
186
4875-4884
2004
Bacillus subtilis, Bacillus subtilis 168
brenda
Burguiere, P.; Fert, J.; Guillouard, I.; Auger, S.; Danchin, A.; Martin-Verstraete, I.
Regulation of the Bacillus subtilis ytmI operon, involved in sulfur metabolism
J. Bacteriol.
187
6019-6030
2005
Bacillus subtilis, Bacillus subtilis 168
brenda
Chonoles Imlay, K.R.; Korshunov, S.; Imlay, J.A.
Physiological roles and adverse effects of the two cystine importers of Escherichia coli
J. Bacteriol.
197
3629-3644
2015
Escherichia coli
brenda
Berger, E.; Heppel, L.
A binding protein involved in the transport of cystine and diaminopimelic acid in Escherichia coli
J. Biol. Chem.
247
7684-7694
1972
Escherichia coli, Escherichia coli ATCC 9637
brenda
Bulut, H.; Moniot, S.; Licht, A.; Scheffel, F.; Gathmann, S.; Saenger, W.; Schneider, E.
Crystal structures of two solute receptors for L-cystine and L-cysteine, respectively, of the human pathogen Neisseria gonorrhoeae
J. Mol. Biol.
415
560-572
2012
Neisseria gonorrhoeae, Neisseria gonorrhoeae FA 1090
brenda
Vergauwen, B.; Verstraete, K.; Senadheera, D.B.; Dansercoer, A.; Cvitkovitch, D.G.; Guedon, E.; Savvides, S.N.
Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans
Mol. Microbiol.
89
288-303
2013
Streptococcus mutans, Streptococcus mutans UA159
brenda
Ohtsu, I.; Kawano, Y.; Suzuki, M.; Morigasaki, S.; Saiki, K.; Yamazaki, S.; Nonaka, G.; Takagi, H.
Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli
PLoS ONE
10
e0120619
2015
Escherichia coli
brenda