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Information on EC 7.2.4.2 - oxaloacetate decarboxylase (Na+ extruding)

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EC Tree
IUBMB Comments
The enzyme from the bacterium Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+. Differs from EC 4.1.1.112 (oxaloacetate decarboxylase) for which there is no evidence for involvement in Na+ transport.
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The enzyme appears in viruses and cellular organisms
Synonyms
EC 4.1.1.3, Oad-alpha, oxaloacetate decarboxylase primary Na+ pump, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
oxaloacetate + 2 Na+[side 1] = pyruvate + CO2 + 2 Na+[side 2]
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oxaloacetate = pyruvate + CO2
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PATHWAY SOURCE
PATHWAYS
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