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The expected taxonomic range for this enzyme is: Oryctolagus cuniculus
Synonyms
5-Phosphoribosylimidazoleacetate synthetase, Synthetase, phosphoribosylimidazoleacetate,
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5-Phosphoribosylimidazoleacetate synthetase
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Synthetase, phosphoribosylimidazoleacetate
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ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate + H2O = ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate
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imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)
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ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate
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ATP + imidazoleacetic acid + 5-phosphoribosyl diphosphate
ADP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate
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CTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate
CDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate
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GTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate
GDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate
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ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate
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0.0034
5-phosphoribosyl diphosphate
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0.372
imidazoleacetate
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7.2 - 9
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pH 7.2: about 50% of maximal activity, pH 9.0: about 25% of maximal activity
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brenda
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brenda
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brenda
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4°C, 0.001 M mercaptoethanol, 50% loss of activity after 1 week
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Crowley, G.M.
The enzymatic synthesis of 5'-phosphoribosylimidazoleacetic acid
J. Biol. Chem.
239
2593-2601
1964
Oryctolagus cuniculus
brenda
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