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Information on EC 6.3.4.3 - formate-tetrahydrofolate ligase

for references in articles please use BRENDA:EC6.3.4.3

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IUBMB Comments

In eukaryotes occurs as a trifunctional enzyme also having methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) activity.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
formyltetrahydrofolate synthetase, fthfs, c1-thf synthase, mthfd, 10-formyltetrahydrofolate synthetase, c1-tetrahydrofolate synthase, 10-formyl-thf synthetase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase 1-like, n10-formyltetrahydrofolate synthetase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
folate polyglutamylation, folate transformations I, folate transformations II (plants), formate assimilation into 5,10-methylenetetrahydrofolate, reductive acetyl coenzyme A pathway I (homoacetogenic bacteria), reductive glycine pathway of autotrophic CO2 fixation
Highest Expressing Human Cell Lines
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