Reference on EC 6.3.4.15 - biotin-[biotin carboxyl-carrier protein] ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dupuis, L.; Leon-del Rio, A.; Leclerc, D.; Campeau, E.; Sweetman, L.; Saudubray, J.M.; Herman, G.; Gibson, K.M.; Gravel, R.A.
Clustering of mutations in the biotin-binding region of holocarboxylase synthetase in biotin-responsive multiple carboxylase deficiency
Hum. Mol. Genet.
5
1011-1016
1996
Homo sapiens
Barker, D.F.; Campbell, A.M.
The birA gene of Escherichia coli encodes a biotin holoenzyme synthetase
J. Mol. Biol.
146
451-467
1981
Escherichia coli
Barker, D.F.; Campbell, A.M.
Genetic and biochemical characterization of the birA gene and its product: evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin operon in Escherichia coli
J. Mol. Biol.
146
469-492
1981
Escherichia coli
Mishina, M.; Roggenkamp, R.; Schweizer, E.
Yeast mutants defective in acetyl-coenzyme A carboxylase and biotin:apocarboxylase ligase
Eur. J. Biochem.
111
79-87
1980
Saccharomyces cerevisiae, Rattus norvegicus
Landman, A.D.; Desjardins, P.R.; Dakshinamurti, K.
A simple assay for acetyl-CoA holocarboxylase synthetase
Can. J. Biochem.
54
813-815
1976
Rattus norvegicus
Landman, A.D.; Dakshinamurti, K.
Enzymatic diagnosis of holocarboxylase synthetase deficiency using apo-carboxyl carrier protein as a substrate
Clin. Chim. Acta
251
41-52
1996
Homo sapiens
de Boer, E.; Rodriguez, P.; Bonte, E.; Krijgsveld, J.; Katsantoni, E.; Heck, A.; Grosveld, F.; Strouboulis, J.
Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice
Proc. Natl. Acad. Sci. USA
100
7480-7485
2003
Escherichia coli
Chapman-Smith, A.; Mulhern, T.D.; Whelan, F.; Cronan, J.E., Jr.; Wallace, J.C.
The C-terminal domain of biotin protein ligase from E. coli is required for catalytic activity
Protein Sci.
10
2608-2617
2001
Escherichia coli
Bagautdinov, B.; Kuroishi, C.; Sugahara, M.; Kunishima, N.
Purification, crystallization and preliminary crystallographic analysis of the biotin-protein ligase from Pyrococcus horikoshii OT3
Acta Crystallogr. Sect. F
61
193-195
2005
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Parthasarathy, R.; Bajaj, J.; Boder, E.T.
An immobilized biotin ligase: surface display of Escherichia coli BirA on Saccharomyces cerevisiae
Biotechnol. Prog.
21
1627-1631
2005
Escherichia coli
Bagautdinov, B.; Kuroishi, C.; Sugahara, M.; Kunishima, N.
Crystal structures of biotin protein ligase from Pyrococcus horikoshii OT3 and its complexes: structural basis of biotin activation
J. Mol. Biol.
353
322-333
2005
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Choi-Rhee, E.; Schulman, H.; Cronan, J.E.
Promiscuous protein biotinylation by Escherichia coli biotin protein ligase
Protein Sci.
13
3043-3050
2004
Escherichia coli
Bagautdinov, B.; Matsuura, Y.; Bagautdinova, S.; Kunishima, N.
Crystallization and preliminary X-ray crystallographic studies of the biotin carboxyl carrier protein and biotin protein ligase complex from Pyrococcus horikoshii OT3
Acta Crystallogr. Sect. F
63
334-337
2007
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Sueda, S.; Li, Y.Q.; Kondo, H.; Kawarabayasi, Y.
Substrate specificity of archaeon Sulfolobus tokodaii biotin protein ligase
Biochem. Biophys. Res. Commun.
344
155-159
2006
Sulfurisphaera tokodaii (F9VNG7), Sulfurisphaera tokodaii 7 (F9VNG7)
Streaker, E.D.; Beckett, D.
The biotin regulatory system: kinetic control of a transcriptional switch
Biochemistry
45
6417-6425
2006
Escherichia coli
Chen, I.; Choi, Y.A.; Ting, A.Y.
Phage display evolution of a peptide substrate for yeast biotin ligase and application to two-color quantum dot labeling of cell surface proteins
J. Am. Chem. Soc.
129
6619-6625
2007
Saccharomyces cerevisiae, Escherichia coli
Gralla, M.; Camporeale, G.; Zempleni, J.
Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus
J. Nutr. Biochem.
19
400-408
2008
Homo sapiens
Bennett, C.B.; Westmoreland, T.J.; Verrier, C.S.; Blanchette, C.A.; Sabin, T.L.; Phatnani, H.P.; Mishina, Y.V.; Huper, G.; Selim, A.L.; Madison, E.R.; Bailey, D.D.; Falae, A.I.; Galli, A.; Olson, J.A.; Greenleaf, A.L.; Marks, J.R.
Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction
PLoS ONE
3
e1448
2008
Mycobacterium tuberculosis
Gupta, V.; Gupta, R.K.; Khare, G.; Surolia, A.; Salunke, D.M.; Tyagi, A.K.
Crystallization and preliminary X-ray diffraction analysis of biotin acetyl-CoA carboxylase ligase (BirA) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
64
524-527
2008
Mycobacterium tuberculosis (P96884), Mycobacterium tuberculosis
Pendini, N.R.; Polyak, S.W.; Booker, G.W.; Wallace, J.C.; Wilce, M.C.
Purification, crystallization and preliminary crystallographic analysis of biotin protein ligase from Staphylococcus aureus
Acta Crystallogr. Sect. F
F64
520-523
2008
Staphylococcus aureus
Ng, B.; Polyak, S.W.; Bird, D.; Bailey, L.; Wallace, J.C.; Booker, G.W.
Escherichia coli biotin protein ligase: characterization and development of a high-throughput assay
Anal. Biochem.
376
131-136
2008
Escherichia coli
Maeda, Y.; Yoshino, T.; Takahashi, M.; Ginya, H.; Asahina, J.; Tajima, H.; Matsunaga, T.
Noncovalent immobilization of streptavidin on in vitro- and in vivo-biotinylated bacterial magnetic particles
Appl. Environ. Microbiol.
74
5139-5145
2008
Magnetospirillum magneticum, Magnetospirillum magneticum AMB-1
Pendini, N.R.; Bailey, L.M.; Booker, G.W.; Wilce, M.C.; Wallace, J.C.; Polyak, S.W.
Biotin protein ligase from Candida albicans: expression, purification and development of a novel assay
Arch. Biochem. Biophys.
479
163-169
2008
Candida albicans, Candida albicans CBF562
Pendini, N.R.; Bailey, L.M.; Booker, G.W.; Wilce, M.C.; Wallace, J.C.; Polyak, S.W.
Microbial biotin protein ligases aid in understanding holocarboxylase synthetase deficiency
Biochim. Biophys. Acta
1784
973-982
2008
Saccharomyces cerevisiae, Homo sapiens, Pyrococcus horikoshii, Escherichia coli (P06709), Pyrococcus horikoshii OT-3
Slavoff, S.A.; Chen, I.; Choi, Y.; Ting, A.Y.
Expanding the substrate tolerance of biotin ligase through exploration of enzymes from diverse species
J. Am. Chem. Soc.
130
1160-1162
2008
Bacillus subtilis, Leuconostoc mesenteroides, Saccharomyces cerevisiae, Escherichia coli, Giardia intestinalis, Homo sapiens, Methanocaldococcus jannaschii, Cutibacterium acnes, Pyrococcus horikoshii, Trypanosoma cruzi
Bagautdinov, B.; Matsuura, Y.; Bagautdinova, S.; Kunishima, N.
Protein biotinylation visualized by a complex structure of biotin protein ligase with a substrate
J. Biol. Chem.
283
14739-14750
2008
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Howarth, M.; Ting, A.Y.
Imaging proteins in live mammalian cells with biotin ligase and monovalent streptavidin
Nat. Protoc.
3
534-545
2008
Escherichia coli
Mize, G.J.; Harris, J.E.; Takayama, T.K.; Kulman, J.D.
Regulated expression of active biotinylated G-protein coupled receptors in mammalian cells
Protein Expr. Purif.
57
280-289
2008
Escherichia coli
Verhaegen, M.; Christopoulos, T.
Recombinant Gaussia luciferase: Overexpression, purification, and analytical application of a bioluminescent reporter for DNA hybridization
Anal. Chem.
74
4378-4385
2002
Escherichia coli K-12 (P06709)
Bailey, L.M.; Wallace, J.C.; Polyak, S.W.
Holocarboxylase synthetase: correlation of protein localisation with biological function
Arch. Biochem. Biophys.
496
45-52
2010
Homo sapiens
Lee, C.K.; Cheong, C.; Jeon, Y.H.
Substrate recognition characteristics of human holocarboxylase synthetase for biotin ligation
Biochem. Biophys. Res. Commun.
391
455-460
2010
Homo sapiens
Zempleni, J.; Wijeratne, S.S.; Hassan, Y.I.
Biotin
Biofactors
35
36-46
2009
Homo sapiens
Yokoi, K.; Ito, T.; Maeda, Y.; Nakajima, Y.; Kurono, Y.; Sugiyama, N.; Togari, H.
A case of holocarboxylase synthetase deficiency with insufficient response to prenatal biotin therapy
Brain Dev.
31
775-778
2009
Homo sapiens
Lee, C.K.; Cheong, C.; Jeon, Y.H.
The N-terminal domain of human holocarboxylase synthetase facilitates biotinylation via direct interaction with the substrate protein
FEBS Lett.
584
675-680
2010
Homo sapiens
Tron, C.M.; McNae, I.W.; Nutley, M.; Clarke, D.J.; Cooper, A.; Walkinshaw, M.D.; Baxter, R.L.; Campopiano, D.J.
Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity
J. Mol. Biol.
387
129-146
2009
Aquifex aeolicus (O66837), Aquifex aeolicus
Wijeratne, S.S.; Camporeale, G.; Zempleni, J.
K12-biotinylated histone H4 is enriched in telomeric repeats from human lung IMR-90 fibroblasts
J. Nutr. Biochem.
21
310-316
2010
Homo sapiens
Maeda, Y.; Yoshino, T.; Matsunaga, T.
In vivo biotinylation of bacterial magnetic particles by a truncated form of Escherichia coli biotin ligase and biotin acceptor peptide
Appl. Environ. Microbiol.
76
5785-5790
2010
Escherichia coli
Daniels, K.; Beckett, D.
Biochemical properties and biological function of a monofunctional microbial biotin protein ligase
Biochemistry
49
5358-5365
2010
Pyrococcus horikoshii (O57883)
Delli-Bovi, T.; Spalding, M.; Prigge, S.
Overexpression of biotin synthase and biotin ligase is required for efficient generation of sulfur-35 labeled biotin in E. coli
BMC Biotechnol.
10
73
2010
Plasmodium falciparum (C6S3D7), Plasmodium falciparum
Gupta, V.; Gupta, R.; Khare, G.; Salunke, D.; Surolia, A.; Tyagi, A.
Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration
PLoS ONE
5
e9222
2010
Mycobacterium tuberculosis (P96884), Mycobacterium tuberculosis
Purushothaman, S.; Annamalai, K.; Tyagi, A.; Surolia, A.
Diversity in functional organization of class I and class II biotin protein ligase
PLoS ONE
6
e16850
2011
Escherichia coli, Mycobacterium tuberculosis (P96884)
Sueda, S.; Tanaka, H.; Yamagishi, M.
A biotin-based protein tagging system
Anal. Biochem.
393
189-195
2009
Sulfurisphaera tokodaii
Sueda, S.; Shinboku, Y.; Kusaba, T.
An SH2 domain-based tyrosine kinase assay using biotin ligase modified with a terbium(III) complex
Anal. Sci.
29
491-497
2013
Sulfurisphaera tokodaii
Li, Y.Q.; Sueda, S.; Kondo, H.; Kawarabayasi, Y.
A unique biotin carboxyl carrier protein in archaeon Sulfolobus tokodaii
FEBS Lett.
580
1536-1540
2006
Escherichia coli, Sulfurisphaera tokodaii (F9VNG7), Sulfurisphaera tokodaii 7 (F9VNG7)
Peters-Wendisch, P.; Stansen, K.C.; Goetker, S.; Wendisch, V.F.
Biotin protein ligase from Corynebacterium glutamicum: role for growth and L: -lysine production
Appl. Microbiol. Biotechnol.
93
2493-2502
2012
Corynebacterium glutamicum (Q8NSG6), Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032 (Q8NSG6)
Soares da Costa, T.P.; Tieu, W.; Yap, M.Y.; Pendini, N.R.; Polyak, S.W.; Sejer Pedersen, D.; Morona, R.; Turnidge, J.D.; Wallace, J.C.; Wilce, M.C.; Booker, G.W.; Abell, A.D.
Selective inhibition of biotin protein ligase from Staphylococcus aureus
J. Biol. Chem.
287
17823-17832
2012
Staphylococcus aureus, Staphylococcus aureus ECT-2
Soares da Costa, T.P.; Yap, M.Y.; Perugini, M.A.; Wallace, J.C.; Abell, A.D.; Wilce, M.C.; Polyak, S.W.; Booker, G.W.
Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus
Mol. Microbiol.
91
110-120
2014
Staphylococcus aureus, Staphylococcus aureus ECT-R2
Li, Y.; Sousa, R.
Expression and purification of E. coli BirA biotin ligase for in vitro biotinylation
Protein Expr. Purif.
82
162-167
2012
Escherichia coli, Escherichia coli AVB101
Pendini, N.R.; Yap, M.Y.; Traore, D.A.; Polyak, S.W.; Cowieson, N.P.; Abell, A.; Booker, G.W.; Wallace, J.C.; Wilce, J.A.; Wilce, M.C.
Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: an antibiotic target
Protein Sci.
22
762-773
2013
Staphylococcus aureus, Staphylococcus aureus ECT-R2
Chen, X.; Chou, H.H.; Wurtele, E.S.
Holocarboxylase synthetase 1 physically interacts with histone H3 in Arabidopsis
Scientifica
2013
983501
2013
Arabidopsis thaliana
Miyao, H.; Ikeda, Y.; Shiraishi, A.; Kawakami, Y.; Sueda, S.
Immobilization of immunoglobulin-G-binding domain of Protein A on a gold surface modified with biotin ligase
Anal. Biochem.
484
113-121
2015
Sulfurisphaera tokodaii (F9VNG7), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993 (F9VNG7)
Tieu, W.; Jarrad, A.M.; Paparella, A.S.; Keeling, K.A.; Soares da Costa, T.P.; Wallace, J.C.; Booker, G.W.; Polyak, S.W.; Abell, A.D.
Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase
Bioorg. Med. Chem. Lett.
24
4689-4693
2014
Staphylococcus aureus
Lu, W.; Levy, M.; Kincaid, R.; Ellington, A.
Directed evolution of the substrate specificity of biotin ligase
Biotechnol. Bioeng.
111
1071-1081
2014
Escherichia coli
Wang, Z.; Moslehi-Jenabian, S.; Solem, C.; Jensen, P.
Increased expression of pyruvate carboxylase and biotin protein ligase increases lysine production in a biotin prototrophic Corynebacterium glutamicum strain
Eng. Life Sci.
15
73-82
2015
Bacillus subtilis, Bacillus subtilis 168
-
Sam, J.; Sharmila, J.
Molecular docking of benzoxazolone and its derivatives against Staphylococcus aureus biotin protein ligase
Int. J. Pharm. Sci. Rev. Res.
32
72-76
2015
Staphylococcus aureus
-
Bockman, M.R.; Kalinda, A.S.; Petrelli, R.; De la Mora-Rey, T.; Tiwari, D.; Liu, F.; Dawadi, S.; Nandakumar, M.; Rhee, K.Y.; Schnappinger, D.; Finzel, B.C.; Aldrich, C.C.
Targeting Mycobacterium tuberculosis biotin protein ligase (MtBPL) with nucleoside-based bisubstrate adenylation inhibitors
J. Med. Chem.
58
7349-7369
2015
Mycobacterium tuberculosis (I6YFP0), Mycobacterium tuberculosis H37Rv (I6YFP0)
Feng, Y.; Chin, C.; Chakravartty, V.; Gao, R.; Crispell, E.; Weiss, D.; Cronan, J.
The atypical occurrence of two biotin protein ligases in Francisella novicida is due to distinct roles in virulence and biotin metabolism
mBio
6
e00591
2015
Francisella tularensis subsp. novicida
Bond, T.E.H.; Sorenson, A.E.; Schaeffer, P.M.
A green fluorescent protein-based assay for high-throughput ligand-binding studies of a mycobacterial biotin protein ligase
Microbiol. Res.
205
35-39
2017
Mycobacterium tuberculosis (P96884), Mycobacterium tuberculosis CDC 1551 (P96884)
Henke, S.K.; Cronan, J.E.
The Staphylococcus aureus group II biotin protein ligase BirA is an effective regulator of biotin operon transcription and requires the DNA binding domain for full enzymatic activity
Mol. Microbiol.
102
417-429
2016
Staphylococcus aureus (A0A0H3KCT0), Staphylococcus aureus Newman (A0A0H3KCT0)
Henke, S.; Cronan, J.
Successful conversion of the Bacillus subtilis BirA group II biotin protein ligase into a group I ligase
PLoS ONE
9
e96757
2014
Bacillus subtilis (P0CI75), Bacillus subtilis 168 (P0CI75)
Ma, Q.; Akhter, Y.; Wilmanns, M.; Ehebauer, M.T.
Active site conformational changes upon reaction intermediate biotinyl-5-AMP binding in biotin protein ligase from Mycobacterium tuberculosis
Protein Sci.
23
932-939
2014
Mycobacterium tuberculosis (I6YFP0), Mycobacterium tuberculosis H37Rv (I6YFP0)
Paparella, A.; Feng, J.; Blanco-Rodriguez, B.; Feng, Z.; Phetsang, W.; Blaskovich, M.; Cooper, M.; Booker, G.; Polyak, S.; Abell, A.
A template guided approach to generating cell permeable inhibitors of Staphylococcus aureus biotin protein ligase
Tetrahedron
74
1175-1183
2017
Staphylococcus aureus
-
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