The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine---D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
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SYSTEMATIC NAME
IUBMB Comments
D-alanine:D-serine ligase (ADP-forming)
The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine---D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
the vanE operon comprises five genes, with three of them, VanE, VanXYE, and VanTE being sufficient to confer vancomycin resistance whereas the last two encode a two-component system postulated to regulate expression of the operon
despite the presence of genes vanGCar, Clostridium argentinense NCIB 10714 is susceptible to vancomycin and to teicoplanin. vanGCar is not expressed without or with induction by a subinhibitory concentration of vancomycin
the vanE operon comprises five genes, with three of them, VanE, VanXYE, and VanTE being sufficient to confer vancomycin resistance whereas the last two encode a two-component system postulated to regulate expression of the operon
despite the presence of genes vanGCar, Clostridium argentinense NCIB 10714 is susceptible to vancomycin and to teicoplanin. vanGCar is not expressed without or with induction by a subinhibitory concentration of vancomycin
vanL, chromosomal localization, belongs to the vanN operon, genetic organization, DNA and amino acid sequence determination and analysis, sequence comparisons with VanN-type proteins, phylogenetic analysis
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the vanE operon comprises five genes, with three of them, VanE, VanXYE, and VanTE being sufficient to confer vancomycin resistance whereas the last two encode a two-component system postulated to regulate expression of the operon
the vanE operon comprises five genes, with three of them, VanE, VanXYE, and VanTE being sufficient to confer vancomycin resistance whereas the last two encode a two-component system postulated to regulate expression of the operon
the vanE operon comprises five genes, with three of them, VanE, VanXYE, and VanTE being sufficient to confer vancomycin resistance whereas the last two encode a two-component system postulated to regulate expression of the operon
of 7271 Enterococcus-containing clinical samples collected between 2004 and 2009, 16 vancomycin resistant enterococci were identified. The vanC1 resistance gene was found in 14 Enterococcus gallinarum and the vanC2 resistance gene in two Enterococcus casseliflavus strains. Except for two samples, the isolates have different pulsed-field gel electrophoresis types, suggesting sporadic emergence of the resistant bacteria
Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase
Identification of Enterococcus faecium and Enterococcus faecalis as vanC-type Vancomycin-resistant Enterococci (VRE) from sewage and river water in the provincial city of Miyazaki, Japan