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Reference on EC 6.3.1.9 - trypanothione synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nadeau, K.C.
Biochemical studies on protein folding chaperones (HSP90 and cyclophilin) and on trypanosomal enzymes (trypanothione and glutathionylspermidine synthetases) (heat shock protein)
Diss. Abstr. Int. B
56
3744
1995
Crithidia fasciculata
-
Manually annotated by BRENDA team
Smith, K.; Nadeau, K.; Bradley, M.; Walsh, C.; Fairlamb, A.H.
Purification of glutathionylspermidine and trypanothione synthetase from Crithidia fasciculata
Protein Sci.
1
874-883
1992
Crithidia fasciculata
Manually annotated by BRENDA team
Tetaud, E.; Manai, F.; Barrett, M.P.; Nadeau, K.; Walsh, C.T.; Fairlamb, A.H.
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata
J. Biol. Chem.
273
19383-19390
1998
Crithidia fasciculata (O60993), Crithidia fasciculata
Manually annotated by BRENDA team
Henderson, G.B.; Yamaguchi, M.; Novoa, L.; Fairlamb, A.H.; Cerami, A.
Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata
Biochemistry
29
3924-3929
1990
Crithidia fasciculata
Manually annotated by BRENDA team
Ondarza, R.N.; Hernandez, E.; Iturbe, A.; Hurtado, G.; Tamayo, E.M.
Detection by HPLC of a trypanothione synthetase activity in vitro from Entamoeba histolytica
Biotechnol. Appl. Biochem.
30
41-45
1999
Crithidia luciliae, Entamoeba histolytica
-
Manually annotated by BRENDA team
Oza, S.L.; Tetaud, E.; Ariyanayagam, M.R.; Warnon, S.S.; Fairlamb, A.H.
A Single Enzyme Catalyses Formation of Trypanothione from Glutathione and Spermidine in Trypanosoma cruzi
J. Biol. Chem.
277
35853-35861
2002
Trypanosoma cruzi (Q9GT49), Trypanosoma cruzi
Manually annotated by BRENDA team
Ariyanayagam, M.R.; Oza, S.L.; Guther, M.L.S.; Fairlamb, A.H.
Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome
Biochem. J.
391
425-432
2005
Trypanosoma brucei
Manually annotated by BRENDA team
Comini, M.A.; Guerrero, S.A.; Haile, S.; Menge, U.; Lunsdorf, H.; Flohe, L.
Valdiation of Trypanosoma brucei trypanothione synthetase as drug target
Free Radic. Biol. Med.
36
1289-1302
2004
Trypanosoma brucei
Manually annotated by BRENDA team
Comini, M.; Menge, U.; Wissing, J.; Flohe, L.
Trypanothione synthesis in Crithidia revisited
J. Biol. Chem.
280
6850-6860
2005
Crithidia fasciculata (Q5DM89), Crithidia fasciculata
Manually annotated by BRENDA team
Oza, S.L.; Shaw, M.P.; Wyllie, S.; Fairlamb, A.H.
Trypanothione biosynthesis in Leishmania major
Mol. Biochem. Parasitol.
139
107-116
2005
Leishmania major (Q711P7), Leishmania major
Manually annotated by BRENDA team
Oza, S.L.; Wyllie, S.; Fairlamb, A.H.
Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major
Mol. Biochem. Parasitol.
149
117-120
2006
Leishmania major (Q711P7), Leishmania major
Manually annotated by BRENDA team
Fyfe, P.K.; Oza, S.L.; Fairlamb, A.H.; Hunter, W.N.
Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities
J. Biol. Chem.
283
17672-17680
2008
Leishmania major (Q711P7)
Manually annotated by BRENDA team
Comini, M.A.; Dirdjaja, N.; Kaschel, M.; Krauth-Siegel, R.L.
Preparative enzymatic synthesis of trypanothione and trypanothione analogues
Int. J. Parasitol.
39
1059-1062
2009
Crithidia fasciculata
Manually annotated by BRENDA team
Torrie, L.S.; Wyllie, S.; Spinks, D.; Oza, S.L.; Thompson, S.; Harrison, J.R.; Gilbert, I.H.; Wyatt, P.G.; Fairlamb, A.H.; Frearson, J.A.
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis
J. Biol. Chem.
284
36137-36145
2009
Trypanosoma brucei
Manually annotated by BRENDA team
Wyllie, S.; Oza, S.L.; Patterson, S.; Spinks, D.; Thompson, S.; Fairlamb, A.H.
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods
Mol. Microbiol.
74
529-540
2009
Trypanosoma brucei
Manually annotated by BRENDA team
Fitzgerald, M.P.; Madsen, J.M.; Coleman, M.C.; Teoh, M.L.; Westphal, S.G.; Spitz, D.R.; Radi, R.; Domann, F.E.
Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity
Radiat. Res.
174
290-296
2010
Trypanosoma cruzi
Manually annotated by BRENDA team
Saudagar, P.; Dubey, V.K.
Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani
Biol. Chem.
392
1113-1122
2011
Leishmania donovani (G5D5D5), Leishmania donovani, Leishmania donovani UR6 (G5D5D5)
Manually annotated by BRENDA team
Spinks, D.; Torrie, L.S.; Thompson, S.; Harrison, J.R.; Frearson, J.A.; Read, K.D.; Fairlamb, A.H.; Wyatt, P.G.; Gilbert, I.H.
Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors
ChemMedChem
7
95-106
2012
Trypanosoma brucei
Manually annotated by BRENDA team
Leroux, A.E.; Haanstra, J.R.; Bakker, B.M.; Krauth-Siegel, R.L.
Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling
J. Biol. Chem.
288
23751-23764
2013
Trypanosoma brucei, Trypanosoma brucei 449
Manually annotated by BRENDA team
Koch, O.; Cappel, D.; Nocker, M.; Jaeger, T.; Flohe, L.; Sotriffer, C.A.; Selzer, P.M.
Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase
PLoS ONE
8
e56788
2013
Leishmania major
Manually annotated by BRENDA team
Vazquez, C.; Mejia-Tlachi, M.; Gonzalez-Chavez, Z.; Silva, A.; Rodriguez-Zavala, J.S.; Moreno-Sanchez, R.; Saavedra, E.
Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi
FEBS Lett.
591
3881-3894
2017
Trypanosoma cruzi, Trypanosoma cruzi DTU I
Manually annotated by BRENDA team
Sousa, A.F.; Gomes-Alves, A.G.; Benitez, D.; Comini, M.A.; Flohe, L.; Jaeger, T.; Passos, J.; Stuhlmann, F.; Tomas, A.M.; Castro, H.
Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum
Free Radic. Biol. Med.
73
229-238
2014
Leishmania infantum (A4I2Z3), Leishmania infantum, Leishmania infantum MHOM / MA / 67 / ITMAP263 (A4I2Z3)
Manually annotated by BRENDA team
Benitez, D.; Medeiros, A.; Fiestas, L.; Panozzo-Zenere, E.A.; Maiwald, F.; Prousis, K.C.; Roussaki, M.; Calogeropoulou, T.; Detsi, A.; Jaeger, T.; Sarlauskas, J.; Peterlin Masic, L.; Kunick, C.; Labadie, G.R.; Flohe, L.; Comini, M.A.
Identification of novel chemical scaffolds inhibiting trypanothione synthetase from pathogenic trypanosomatids
PLoS Negl. Trop. Dis.
10
e0004617
2016
Leishmania infantum (A4I2Z3), Leishmania infantum, Leishmania infantum JPCM5 /MHOM / MA / 67 / ITMAP263 (A4I2Z3), Trypanosoma brucei brucei (Q8IEX1), Trypanosoma brucei brucei 427 (Q8IEX1), Trypanosoma cruzi (Q9GT49), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q9GT49)
Manually annotated by BRENDA team
Equbal, A.; Suman, S.S.; Anwar, S.; Singh, K.P.; Zaidi, A.; Sardar, A.H.; Das, P.; Ali, V.
Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani
PLoS ONE
9
e97600
2014
Leishmania donovani (Q8IFU8), Leishmania donovani, Leishmania donovani MHOM / IN / 80 / Dd8 (Q8IFU8), Leishmania donovani MHOM / IN / 83 / Ag (Q8IFU8)
Manually annotated by BRENDA team