Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 6.2.1.61 - salicylate-[aryl-carrier protein] ligase

for references in articles please use BRENDA:EC6.2.1.61
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.61 salicylate-[aryl-carrier protein] ligase
IUBMB Comments
The enzyme catalyses the activation of salicylate to (salicyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein, which is often a domain of a larger non-ribosimal peptide synthase. The PmsE enzyme is involved in pseudomonine biosynthesis and transfers the activated salicylate first to itself, and then to a PmsG protein. The PchD enzyme is involved in pyochelin biosynthesis and transfers the activated salicylate directly to the PchE protein.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The expected taxonomic range for this enzyme is: Pseudomonas
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
+
+
holo-[non-ribosomal peptide synthase]
=
+
+
salicyl-[non-ribosomal peptide synthase]
Synonyms
salicyl-amp ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(salicyl)adenylate + holo-[non-ribosomal peptide synthase] = AMP + salicyl-[non-ribosomal peptide synthase]
show the reaction diagram
(1b)
-
-
-
ATP + salicylate + holo-[non-ribosomal peptide synthase] = AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]
show the reaction diagram
overall reaction
-
-
-
ATP + salicylate = diphosphate + (salicyl)adenylate
show the reaction diagram
(1a)
-
-
-
Select items on the left to see more content.