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4-hydroxybenzoate:holo-[4-hydroxyphenylalkanoate synthase] ligase (AMP-forming)
This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase.
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4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
ATP + 4-hydroxybenzoate
4-hydroxybenzoyl-adenylate + diphosphate
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
additional information
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4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Substrates: -
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4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Substrates: -
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ATP + 4-hydroxybenzoate
4-hydroxybenzoyl-adenylate + diphosphate
Substrates: -
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ATP + 4-hydroxybenzoate
4-hydroxybenzoyl-adenylate + diphosphate
Substrates: -
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ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Substrates: -
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ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Substrates: -
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Substrates: FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate
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Substrates: FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate
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additional information
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Substrates: FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate
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4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
ATP + 4-hydroxybenzoate
4-hydroxybenzoyl-adenylate + diphosphate
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
additional information
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4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Substrates: -
Products: -
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4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Substrates: -
Products: -
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ATP + 4-hydroxybenzoate
4-hydroxybenzoyl-adenylate + diphosphate
Substrates: -
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ATP + 4-hydroxybenzoate
4-hydroxybenzoyl-adenylate + diphosphate
Substrates: -
Products: -
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ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Substrates: -
Products: -
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ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase]
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Substrates: -
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additional information
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Substrates: FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate
Products: -
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additional information
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Substrates: FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate
Products: -
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additional information
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Substrates: FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate
Products: -
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FAA22_MYCMM
Mycobacterium marinum (strain ATCC BAA-535 / M)
702
0
75181
Swiss-Prot
-
FAA22_MYCTU
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
705
0
75198
Swiss-Prot
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FAA22_MYCTO
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
705
0
75198
Swiss-Prot
-
FAA22_MYCBO
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
705
0
75198
Swiss-Prot
-
A0A045HFC2_MYCTX
705
0
75198
TrEMBL
-
A0A0H3M7V5_MYCBP
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
705
0
75198
TrEMBL
-
A0A0I9U2B5_9MYCO
705
0
75391
TrEMBL
-
A0A1B4Y1L5_MYCUL
702
0
75197
TrEMBL
-
A0A2I7WB37_MYCTX
705
0
75271
TrEMBL
-
A0A3E2MZU6_MYCMR
702
0
75222
TrEMBL
-
A0A679LIX5_MYCBO
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
705
0
75198
TrEMBL
-
A0A829C8V9_9MYCO
705
0
75198
TrEMBL
-
A0A9N7LTK1_9MYCO
702
0
75223
TrEMBL
-
A0A9P2HAU5_MYCTX
705
0
75198
TrEMBL
-
A0AAU0Q5B0_9MYCO
705
0
75198
TrEMBL
-
A0AB72XRE1_MYCCP
Mycobacterium canettii (strain CIPT 140010059)
705
0
75182
TrEMBL
-
A0AB74LND3_MYCBI
705
0
75198
TrEMBL
-
A5U6V6_MYCTA
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
705
0
75198
TrEMBL
-
L7V209_MYCL1
Mycobacterium liflandii (strain 128FXT)
702
0
75225
TrEMBL
other Location (Reliability: 1)
Q50468_MYCTX
705
0
75170
TrEMBL
other Location (Reliability: 3)
R4M9P8_MYCTX
705
0
75198
TrEMBL
-
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Simeone, R.; Leger, M.; Constant, P.; Malaga, W.; Marrakchi, H.; Daffe, M.; Guilhot, C.; Chalut, C.
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis
FEBS J.
277
2715-2725
2010
Mycobacterium tuberculosis (P9WQ61), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ61)
brenda
Vergnolle, O.; Chavadi, S.S.; Edupuganti, U.R.; Mohandas, P.; Chan, C.; Zeng, J.; Kopylov, M.; Angelo, N.G.; Warren, J.D.; Soll, C.E.; Quadri, L.E.
Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum
J. Bacteriol.
197
1040-1050
2015
Mycobacterium marinum (B2HIL6), Mycobacterium marinum ATCC BAA-535 (B2HIL6)
brenda
Samanta, S.; Singh, A.; Biswas, P.; Bhatt, A.; Visweswariah, S.S.
Mycobacterial phenolic glycolipid synthesis is regulated by cAMP-dependent lysine acylation of FadD22
Microbiology
163
373-382
2017
Mycolicibacterium smegmatis
brenda
Ramos, B.; Gordon, S.V.; Cunha, M.V.
Revisiting the expression signature of pks15/1 unveils regulatory patterns controlling phenolphtiocerol and phenolglycolipid production in pathogenic mycobacteria
PLoS ONE
15
e0229700
2020
Mycobacterium tuberculosis (P9WQ61), Mycobacterium tuberculosis H37Rv (P9WQ61)
brenda
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