Information on EC 6.2.1.2 - butyrate-CoA ligase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC6.2.1.2
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Homo sapiens


The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria


The taxonomic range for the selected organisms is: Homo sapiens

EC NUMBER
COMMENTARY hide
6.2.1.2
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RECOMMENDED NAME
GeneOntology No.
butyrate-CoA ligase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
methyl ketone biosynthesis (engineered)
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Butanoate metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
butanoate:CoA ligase (AMP-forming)
Acts on acids from C4 to C11 and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids.
CAS REGISTRY NUMBER
COMMENTARY hide
9080-51-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
show the reaction diagram
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?
ATP + phenylacetate + CoA
AMP + diphosphate + phenylacetyl-CoA
show the reaction diagram
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?
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
enzyme form HXM-A and HXM-B
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression of HXM-A in COS cells
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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involvement of the MACS2 Leu513Ser polymorphism in the development of the metabolic syndrome