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Information on EC 6.1.1.26 - pyrrolysine-tRNAPyl ligase

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IUBMB Comments
In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNAPyl, with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl---tRNA ligase. The enzyme is specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids .
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The enzyme appears in viruses and cellular organisms
Synonyms
pylrs, pyrrolysyl-trna synthetase, class ii aminoacyl-trna synthetase, pylsn, lysz-rs, pylsc, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + L-pyrrolysine + tRNAPyl = AMP + diphosphate + L-pyrrolysyl-tRNAPyl
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PATHWAY SOURCE
PATHWAYS
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