Reference on EC 6.1.1.18 - glutamine-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Walker, E.J.; Treacy, G.B.; Jeffrey, P.D.
Molecular weights of mitochondrial and cytoplasmic aminoacyl-tRNA synthetases of beef liver and their complexes
Biochemistry
22
1934-1941
1983
Bos taurus
Lea, P.J.; Fowden, L.
Amino acid substrate specificity of asparaginyl-, aspartyl- and glutaminyl-tRNA synthetase isolated from higher plants
Phytochemistry
12
1903-1916
1973
Albizia julibrissin, Vigna radiata var. radiata
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Norcum, M.T.
Isolation and electron microscopic characterization of the high molecular mass aminoacyl-tRNA synthetase complex from murine erythroleukemia cells
J. Biol. Chem.
264
15043-15051
1989
Mus musculus
Rould, M.A.; Perona, J.J.; Söll, D.; Steitz, T.A.
Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNAGln and ATP at 2.8 A resolution
Science
246
1135-1142
1989
Escherichia coli
Conley, J.; Sherman, J.; Thomann, H.U.; Söll, D.
Domains of E. coli glutaminyl-tRNA synthetase disordered in the crystal structure are essential for function or stability
Nucleosides Nucleotides
13
1581-1595
1994
Escherichia coli
-
Thomann, H.U.; Ibba, M.; Hong, K.W.; Söll, D.
Homologous expression and purification of mutants of an essential protein by reverse epitope-tagging
Bio/Technology
14
50-55
1996
Escherichia coli
Rogers, M.J.; Weygand-Durasevic, I.; Schwob, E.; Sherman, J.M.; Rogers, K.C.; Adachi, T.; Inokuchi, H.; Söll, D.
Selectivity and specificity in the recognition of tRNA by E. coli glutaminyl-tRNA synthetase
Biochimie
75
1083-1090
1993
Escherichia coli
Perona, J.J.; Rould, M.A.; Steitz, T.A.; Risler, J.L.; Zelwer, C.; Brunie, S.
Structural similarities in glutaminyl- and methionyl-tRNA synthetases suggest a common overall orientation of tRNA binding
Proc. Natl. Acad. Sci. USA
88
2903-2907
1991
Escherichia coli
Rould, M.A.; Perona, J.J.; Steitz, T.A.
Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase
Nature
352
213-218
1991
Escherichia coli
Bhattacharyya, T.; Bhattacharyya, A.; Roy, S.
A fluorescence spectroscopic study of glutaminyl-tRNA synthetase from Escherichia coli and its implications for the enzyme mechanism
Eur. J. Biochem.
200
739-745
1991
Escherichia coli
Ludmerer, S.W.; Wright, D.J.; Schimmel, P.
Purification of glutamine tRNA synthetase from Saccharomyces cerevisiae
J. Biol. Chem.
268
5519-5523
1993
Saccharomyces cerevisiae
Das, B.K.; Bhattacharyya, T.; Roy, S.
Characterization of a urea induced molten globule intermediate state of glutaminyl-tRNA synthetase from Escherichia coli
Biochemistry
34
5242-5247
1995
Escherichia coli
Arnez, J.G.; Steitz, T.A.
Crystal structures of three misacylating mutants of Escherichia coli glutaminyl-tRNA synthetase complexed with tRNAGln and ATP
Biochemistry
35
14725-14733
1996
Escherichia coli
Fett, R.; Knippers, R.
The primary structure of human glutaminyl-tRNA synthetase
J. Biol. Chem.
266
1448-1455
1991
Homo sapiens
Körner, A.; Magee, B.B.; Liska, B.; Low, K.B.; Adelberg, E.A.; Söll, D.
Isolation and partial characterization of a temperature-sensitive Escherichia coli mutant with altered glutaminyl-transfer ribonucleic acid synthetase
J. Bacteriol.
120
154-158
1974
Escherichia coli
Seno, T.; Nakamura, A.; Fukuhara, S.; Iwata, K.
Interaction of Escherichia coli glutaminyl-tRNA synthetase with noncognate tRNA's
Nucleic Acids Res.
5
1561-1570
1978
Escherichia coli
Kern, D.; Potier, S.; Lapointe, J.; Boulanger, Y.
The glutaminyl-transfer RNA synthetase of Escherichia coli. Purification, structure and function relationship
Biochim. Biophys. Acta
607
65-80
1980
Escherichia coli
Yamao, F.; Inokuchi, H.; Cheung, A.; Ozeki, H.; Söll, D.
Escherichia coli glutaminyl-tRNA synthetase. I. Isolation and DNA sequence of the glnS gene
J. Biol. Chem.
257
11639-11643
1982
Escherichia coli
Hoben, P.; Royal, N.; Cheung, A.; Yamao, F.; Biemann, K.; Söll, D.
Escherichia coli glutaminyl-tRNA synthetase. II. Characterization of the glnS gene product
J. Biol. Chem.
257
11644-11650
1982
Escherichia coli
Mitchell, A.P.; Ludmerer, S.W.
Identification of a glutaminyl-tRNA synthetase mutation in Saccharomyces cerevisiae
J. Bacteriol.
158
530-534
1984
Saccharomyces cerevisiae
Ludmerer, S.W.; Schimmel, P.
Cloning of GLN4: an essential gene that encodes glutaminyl-tRNA synthetase in Saccharomyces cerevisiae
J. Bacteriol.
163
763-768
1985
Saccharomyces cerevisiae
Hoben, P.; Söll, D.
Glutaminyl-tRNA synthetase of Escherichia coli
Methods Enzymol.
113
55-59
1985
Escherichia coli
Liu, J.; Ibba, M.; Hong, K.W.; Soll, D.
The terminal adenosine of tRNA(Gln) mediates tRNA-dependent amino acid recognition by glutaminyl-tRNA synthetase
Biochemistry
37
9836-9842
1998
Escherichia coli
Bernier, S.; Dubois, D.Y.; Therrien, M.; Lapointe, J.; Chenevert, R.
Synthesis of glutaminyl adenylate analogues that are inhibitors of glutaminyl-tRNA synthetase
Bioorg. Med. Chem. Lett.
10
2441-2444
2000
Escherichia coli
Hong, K.W.; Ibba, M.; Soll, D.
Retracing the evolution of amino acid specificity in glutaminyl-tRNA synthetase
FEBS Lett.
434
149-154
1998
Escherichia coli
Kim, T.; Park, S.G.; Kim, J.E.; Seol, W.; Ko, Y.G.; Kim, S.
Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex
J. Biol. Chem.
275
21768-21772
2000
Homo sapiens
Ko, Y.G.; Kim, E.Y.; Kim, T.; Park, H.; Park, H.S.; Choi, E.J.; Kim, S.
Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1
J. Biol. Chem.
276
6030-6036
2001
Homo sapiens
Krzyzaniak, A.; Siatecka, M.; Szyk, A.; Mucha, P.; Rekowski, P.; Kupryszewski, G.; Barciszewski, J.
Specific induction of Z-DNA conformation by a nuclear localization signal peptide of lupin glutaminyl tRNA synthetase
Mol. Biol. Rep.
27
51-54
2000
Lupinus luteus
Mandal, A.K.; Bhattacharyya, A.; Bhattacharyya, S.; Bhattacharyya, T.; Roy, S.
A cognate tRNA specific conformational change in glutaminyl-tRNA synthetase and its implication for specificity
Protein Sci.
7
1046-1051
1998
Escherichia coli
Rath, V.L.; Silvian, L.F.; Beijer, B.; Sproat, B.S.; Steitz, T.A.
How glutaminyl-tRNA synthetase selects glutamine
Structure
6
439-449
1998
Escherichia coli (P00962)
Akochy, P.M.; Bernard, D.; Roy, P.H.; Lapointe, J.
Direct glutaminyl-tRNA biosynthesis and indirect asparaginyl-tRNA biosynthesis in Pseudomonas aeruginosa PAO1
J. Bacteriol.
186
767-776
2004
Pseudomonas aeruginosa
Rinehart, J.; Horn, E.K.; Wei, D.; Soll, D.; Schneider, A.
Non-canonical eukaryotic glutaminyl- and glutamyl-tRNA synthetases form mitochondrial aminoacyl-tRNA in Trypanosoma brucei
J. Biol. Chem.
279
1161-1166
2004
Trypanosoma brucei
Deniziak, M.A.; Sauter, C.; Becker, H.D.; Giege, R.; Kern, D.
Crystallization and preliminary X-ray characterization of the atypical glutaminyl-tRNA synthetase from Deinococcus radiodurans
Acta Crystallogr. Sect. D
60
2361-2363
2004
Deinococcus radiodurans
Rinehart, J.; Krett, B.; Rubio, M.A.; Alfonzo, J.D.; Soll, D.
Saccharomyces cerevisiae imports the cytosolic pathway for Gln-tRNA synthesis into the mitochondrion
Genes Dev.
19
583-592
2005
Saccharomyces cerevisiae
Gruic-Sovulj, I.; Uter, N.; Bullock, T.; Perona, J.J.
tRNA-dependent aminoacyl-adenylate hydrolysis by a nonediting class I aminoacyl-tRNA synthetase
J. Biol. Chem.
280
23978-23986
2005
Escherichia coli
Green, D.F.; Tidor, B.
Escherichia coli glutaminyl-tRNA synthetase is electrostatically optimized for binding of its cognate substrates
J. Mol. Biol.
342
435-452
2004
Escherichia coli
Uter, N.T.; Perona, J.J.
Long-range intramolecular signaling in a tRNA synthetase complex revealed by pre-steady-state kinetics
Proc. Natl. Acad. Sci. USA
101
14396-14401
2004
Escherichia coli
Uter, N.T.; Perona, J.J.
Active-site assembly in glutaminyl-tRNA synthetase by tRNA-mediated induced fit
Biochemistry
45
6858-6865
2006
Escherichia coli
Balg, C.; Blais, S.P.; Bernier, S.; Huot, J.L.; Couture, M.; Lapointe, J.; Chenevert, R.
Synthesis of beta-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases
Bioorg. Med. Chem.
15
295-304
2007
Escherichia coli
Yamasaki, S.; Nakamura, S.; Terada, T.; Shimizu, K.
Mechanism of the difference in the binding affinity of E. coli tRNAGln to glutaminyl-tRNA synthetase caused by noninterface nucleotides in variable loop
Biophys. J.
92
192-200
2007
Escherichia coli (P00962)
Deniziak, M.; Sauter, C.; Becker, H.D.; Paulus, C.A.; Giege, R.; Kern, D.
Deinococcus glutaminyl-tRNA synthetase is a chimer between proteins from an ancient and the modern pathways of aminoacyl-tRNA formation
Nucleic Acids Res.
35
1421-1431
2007
Deinococcus radiodurans (P56926), Deinococcus radiodurans, Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 (P56926)
Sathyapriya, R.; Vishveshwara, S.
Structure networks of E. coli glutaminyl-tRNA synthetase: effects of ligand binding
Proteins
68
541-550
2007
Escherichia coli (P00962), Escherichia coli
Saha, R.; Dasgupta, S.; Basu, G.; Roy, S.
A chimeric glutamyl: glutaminyl-tRNA synthetase: implications for evolution
Biochem. J.
15
449-455
2008
Escherichia coli
Wong, S.; Ragan, M.A.
MACHOS: Markov clusters of homologous subsequences
Bioinformatics
24
i77-i85
2008
Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Bullock, T.L.; Rodriguez-Hernandez, A.; Corigliano, E.M.; Perona, J.J.
A rationally engineered misacylating aminoacyl-tRNA synthetase
Proc. Natl. Acad. Sci. USA
105
7428-7433
2008
Escherichia coli, Escherichia coli (P00962)
Dasgupta, S.; Saha, R.; Dey, C.; Banerjee, R.; Roy, S.; Basu, G.
The role of the catalytic domain of E. coli GluRS in tRNAGln discrimination
FEBS Lett.
583
2114-2120
2009
Escherichia coli
Rodriguez-Hernandez, A.; Perona, J.J.
Heat maps for intramolecular communication in an RNP enzyme encoding glutamine
Structure
19
386-396
2011
Escherichia coli
Saha, R.; Dasgupta, S.; Banerjee, R.; Mitra-Bhattacharyya, A.; Soell, D.; Basu, G.; Roy, S.
A functional loop spanning distant domains of glutaminyl-tRNA synthetase also stabilizes a molten globule state
Biochemistry
51
4429-4437
2012
Escherichia coli (P00962)
Grant, T.D.; Luft, J.R.; Wolfley, J.R.; Snell, M.E.; Tsuruta, H.; Corretore, S.; Quartley, E.; Phizicky, E.M.; Grayhack, E.J.; Snell, E.H.
The structure of yeast glutaminyl-tRNA synthetase and modeling of its interaction with tRNA
J. Mol. Biol.
425
2480-2493
2013
Saccharomyces cerevisiae (P13188), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P13188)
Zhang, X.; Ling, J.; Barcia, G.; Jing, L.; Wu, J.; Barry, B.J.; Mochida, G.H.; Hill, R.S.; Weimer, J.M.; Stein, Q.; Poduri, A.; Partlow, J.N.; Ville, D.; Dulac, O.; Yu, T.W.; Lam, A.T.; Servattalab, S.; Rodriguez, J.; Boddaert, N.; Munnich, A.; Colleaux, L.; Zon, L.I.; Soell, D.; Walsh, C.A.; Nabbout, R.
Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures
Am. J. Hum. Genet.
94
547-558
2014
Homo sapiens (P47897)
Kodera, H.; Osaka, H.; Iai, M.; Aida, N.; Yamashita, A.; Tsurusaki, Y.; Nakashima, M.; Miyake, N.; Saitsu, H.; Matsumoto, N.
Mutations in the glutaminyl-tRNA synthetase gene cause early-onset epileptic encephalopathy
J. Hum. Genet.
60
97-101
2015
Homo sapiens (P47897)
Hadd, A.; Perona, J.J.
Coevolution of specificity determinants in eukaryotic glutamyl- and glutaminyl-tRNA synthetases
J. Mol. Biol.
426
3619-3633
2014
Saccharomyces cerevisiae (P13188), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 / S288c (P13188)
Druart, K.; Guennec, M.L.; Palmai, Z.; Simonson, T.
Probing the stereospecificity of tyrosyl- and glutaminyl-tRNA synthetase with molecular dynamics
J. Mol. Graph. Model.
71
192-199
2017
Escherichia coli (P00962), Escherichia coli
Ognjenovic, J.; Wu, J.; Matthies, D.; Baxa, U.; Subramaniam, S.; Ling, J.; Simonovic, M.
The crystal structure of human GlnRS provides basis for the development of neurological disorders
Nucleic Acids Res.
44
3420-3431
2016
Homo sapiens (P47897), Homo sapiens
Fu, Y.; Kim, Y.; Jin, K.S.; Kim, H.S.; Kim, J.H.; Wang, D.; Park, M.; Jo, C.H.; Kwon, N.H.; Kim, D.; Kim, M.H.; Jeon, Y.H.; Hwang, K.Y.; Kim, S.; Cho, Y.
Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation
Proc. Natl. Acad. Sci. USA
111
15084-15089
2014
Homo sapiens (P47897)
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