Reference on EC 6.1.1.14 - glycine-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Walker, E.J.; Treacy, G.B.; Jeffrey, P.D.
Molecular weights of mitochondrial and cytoplasmic aminoacyl-tRNA synthetases of beef liver and their complexes
Biochemistry
22
1934-1941
1983
Bos taurus
Freist, W.; Logan, D.T.; Gauss, D.H.
Glycyl-tRNA synthetase
Biol. Chem. Hoppe-Seyler
377
343-356
1996
Alcaligenes faecalis, Aliivibrio fischeri, Bombyx mori, Bos taurus, Brevibacillus brevis, Chlamydia trachomatis, Escherichia coli, eukaryota, Gallus gallus, Geobacillus stearothermophilus, Haemophilus influenzae, Homo sapiens, Mus musculus, Mycoplasma genitalium, Rattus norvegicus, Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium, Staphylococcus aureus, Thermus thermophilus
Williams, J.; Osvath, S.; Khong, T.F.; Pearse.M.; Power, D.
Cloning, sequencing and bacterial expression of human glycine tRNA synthetase
Nucleic Acids Res.
23
1307-1310
1995
Homo sapiens
Toth, M.J.; Schimmel, P.
A mutation in the small subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters
J. Biol. Chem.
265
1005-1009
1990
Escherichia coli
Ge, Q.; Trieu, E.P.; Targoff, I.N.
Primary structure and functional expression in human glycyl-tRNA synthetase, an autoantigen in myositis
J. Biol. Chem.
269
28790-28797
1994
Homo sapiens
Shiba, K.; Schimmel, P.; Motegi, H.; Noda, T.
Human glycyl-tRNA synthetase. Wide divergence of primary structure from bacterial counterpart and species-specific aminoacylation
J. Biol. Chem.
269
30049-30055
1994
Bombyx mori, Saccharomyces cerevisiae, Escherichia coli, Homo sapiens
Nameki, N.; Tamura, K.; Asahara, H.; Hasegawa, T.
Recognition of tRNAGly by three widely diverged glycyl-tRNA synthetases
J. Mol. Biol.
268
640-647
1997
Escherichia coli, Saccharomyces cerevisiae, Thermus thermophilus
Wagar, E.A.; Giese, M.J.; Yasin, B.; Pang, M.
The glycyl-tRNA synthetase of Chlamydia trachomatis
J. Bacteriol.
177
5179-5185
1995
Chlamydia trachomatis
Wu, H.; Nada, S.; Dignam, D.
Analysis of truncated forms of Bombyx mori glycyl-tRNA synthetase: Function of an N-terminal structure in RNA binding
Biochemistry
34
16327-16336
1995
Bombyx mori
Logan, D.T.; Mazauric, M.H.; Kern, D.; Moras, D.
Crystal structure of glycyl-tRNA synthetase from Thermus thermophilus
EMBO J.
14
4156-4167
1995
Thermus thermophilus
Niyomporn, B.; Dahl, J.L.; Strominger, J.L.
Biosynthesis of the peptidoglycan of bacterial cell walls. IX. Purification and properties of glycyl transfer ribonucleic acid synthetase from Staphylococcus aureus
J. Biol. Chem.
243
773-778
1968
Staphylococcus aureus, Staphylococcus aureus H
Kurosawa, S.; Komano, T.; Onodera, K.
Glycine activating enzyme in the posterior silkgland of silkworm
Agric. Biol. Chem.
36
779-784
1972
Bombyx mori
-
Kurosawa, S.; Onodera, K.
Correlation between two glycine tRNAs and corresponding glycyl tRNA synthetase
Agric. Biol. Chem.
36
1051-1053
1972
Bombyx mori
-
Roback, E.R.; Friesen, J.D.; Fiil, N.P.
A temperature-sensitive glycyl-transfer ribonucleic acid synthetase mutant of Escherichia coli
Can. J. Microbiol.
19
421-426
1972
Escherichia coli
Ostrem, D.L.; Berg, P.
Glycyl transfer ribonucleic acid synthetase from Escherichia coli. Purification, properties, and substrate binding
Biochemistry
13
1338-1348
1974
Escherichia coli
Surguchov, A.P.; Surguchova, I.G.
Two enzymatically active forms of glycyl-tRNA synthetase from Bacillus brevis
Eur. J. Biochem.
54
175-184
1975
Brevibacillus brevis
Francis, T.A.; Nagel, G.M.
Glycyl-tRNA synthetase: evidence for two enzyme forms and sigmoidal saturation kinetics
Biochem. Biophys. Res. Commun.
70
862-868
1976
Escherichia coli
McDonald, T.; Breite, L.; Pangburn, K.L.W.; Hom, S.; Manser, J.; Nagel, G.M.
Overproduction, purification, and subunit structure of Escherichia coli glycyl transfer ribonucleic acid synthetase
Biochemistry
19
1402-1409
1980
Escherichia coli, Escherichia coli overproducing
Kern, D.; Giege, R.; Ebel, J.P.
Glycyl-tRNA synthetase from baker's yeast. Interconversion between active and inactive forms of the enzyme
Biochemistry
20
122-131
1981
Saccharomyces cerevisiae
Wright, H.T.; Nurse, K.C.; Goldstein, D.J.
Naldixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases
Science
213
455-456
1981
Escherichia coli, Saccharomyces cerevisiae
Keng, T.; Webster, T.A.; Sauer, R.T.; Schimmel, P.
Gene for Escherichia coli glycyl-tRNA synthetase has tandem subunit coding regions in the same reading frame
J. Biol. Chem.
257
12503-12508
1982
Escherichia coli
Webster, T.A.; Gibson, B.W.; Keng, T.; Biemann, K.; Schimmel, P.
Primary structures of both subunits of Escherichia coli glycyl-tRNA synthetase
J. Biol. Chem.
258
10637-10641
1983
Escherichia coli
Led, J.J.; Switon, W.K.; Jensen, K.F.
Phosphorolytic activity of Escherichia coli glycyl-tRNA synthetase towards its cognate aminoacyl adenylate detected by 31P-NMR spectroscopy and thin-layer chromatography
Eur. J. Biochem.
136
469-479
1983
Escherichia coli
Dignam, S.S.; Dignam, J.D.
Glycyl- and alanyl-tRNA synthetases from Bombyx mori. Purification and properties
J. Biol. Chem.
259
4043-4048
1984
Bombyx mori
Nagel, G.M.; Cumberledge, S.; Johnson, M.S.; Petrella, E.; Weber, B.H.
The beta subunit of E. coli glycyl-tRNA synthetase plays a major role in tRNA recognition
Nucleic Acids Res.
12
4377-4384
1984
Escherichia coli
Kawakami, M; Nishio, K.
Subunit structure and tRNA-binding properties of Bombyx mori glycyl-tRNA synthetase
J. Biochem.
98
177-186
1985
Bombyx mori
Toth, M.J.; Schimmel, P.
Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusion
J. Biol. Chem.
261
6643-6646
1986
Escherichia coli
Dignam, J.D.; Nada, S.; Chaires, J.B.
Thermodynamic characterization of the binding of nucleotides to glycyl-tRNA synthetase
Biochemistry
42
5333-5340
2003
Bombyx mori
Mazauric, M.H.; Keith, G.; Logan, D.; Kreutzer, R.; Giege, R.; Kern, D.
Glycyl-tRNA synthetase from Thermus thermophilus--wide structural divergence with other prokaryotic glycyl-tRNA synthetases and functional inter-relation with prokaryotic and eukaryotic glycylation systems
Eur. J. Biochem.
251
744-757
1998
Thermus thermophilus
Mudge, S.J.; Williams, J.H.; Eyre, H.J.; Sutherland, G.R.; Cowan, P.J.; Power, D.A.
Complex organisation of the 5'-end of the human glycine tRNA synthetase gene
Gene
209
45-50
1998
Homo sapiens (P41250), Homo sapiens
Magrath, C.; Hyman, L.E.
A mutation in GRS1, a glycyl-tRNA synthetase, affects 3'-end formation in Saccharomyces cerevisiae
Genetics
152
129-141
1999
Saccharomyces cerevisiae
Turner, R.J.; Lovato, M.; Schimmel, P.
One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae provides mitochondrial and cytoplasmic functions
J. Biol. Chem.
275
27681-27688
2000
Saccharomyces cerevisiae
Nathanson, L.; Deutscher, M.P.
Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex
J. Biol. Chem.
275
31559-31562
2000
Cricetulus griseus, Oryctolagus cuniculus
Duchene, A.M.; Peeters, N.; Dietrich, A.; Cosset, A.; Small, I.D.; Wintz, H.
Overlapping destinations for two dual targeted glycyl-tRNA synthetases in Arabidopsis thaliana and Phaseolus vulgaris
J. Biol. Chem.
276
15275-15283
2001
Phaseolus vulgaris, Arabidopsis thaliana (O23627), Arabidopsis thaliana (Q8L785), Arabidopsis thaliana
Dignam, J.D.; Qu, X.; Chaires, J.B.
Equilibrium unfolding of Bombyx mori glycyl-tRNA synthetase
J. Biol. Chem.
276
4028-4037
2001
Bombyx mori
Johanson, K.; Hoang, T.; Sheth, M.; Hyman, L.E.
GRS1, a yeast tRNA synthetase with a role in mRNA 3' end formation
J. Biol. Chem.
278
35923-35930
2003
Saccharomyces cerevisiae
Uwer, U.; Willmitzer, L.; Altmann, T.
Inactivation of a glycyl-tRNA synthetase leads to an arrest in plant embryo development
Plant Cell
10
1277-1294
1998
Arabidopsis thaliana (Q8L785)
Chang, K.J.; Wang, C.C.
Translation initiation from a naturally occurring non-AUG codon in Saccharomyces cerevisiae
J. Biol. Chem.
279
13778-13785
2004
Saccharomyces cerevisiae
Xie, W.; Schimmel, P.; Yang, X.L.
Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease
Acta Crystallogr. Sect. F
62
1243-1246
2006
Homo sapiens (P41250), Homo sapiens
Cader, M.Z.; Ren, J.; James, P.A.; Bird, L.E.; Talbot, K.; Stammers, D.K.
Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy
FEBS Lett.
581
2959-2964
2007
Homo sapiens
Shimizu, H.; Yokobori, S.; Ohkuri, T.; Yokogawa, T.; Nishikawa, K.; Yamagishi, A.
Extremely thermophilic translation system in the common ancestor commonote: ancestral mutants of Glycyl-tRNA synthetase from the extreme thermophile Thermus thermophilus
J. Mol. Biol.
369
1060-1069
2007
Thermus thermophilus (P56206), Thermus thermophilus
Antonellis, A.; Lee-Lin, S.Q.; Wasterlain, A.; Leo, P.; Quezado, M.; Goldfarb, L.G.; Myung, K.; Burgess, S.; Fischbeck, K.H.; Green, E.D.
Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons
J. Neurosci.
26
10397-10406
2006
Homo sapiens (P41250), Homo sapiens
Seburn, K.L.; Nangle, L.A.; Cox, G.A.; Schimmel, P.; Burgess, R.W.
An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model
Neuron
51
715-726
2006
Mus musculus
Nangle, L.A.; Zhang, W.; Xie, W.; Yang, X.L.; Schimmel, P.
Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect
Proc. Natl. Acad. Sci. USA
104
11239-11244
2007
Homo sapiens
Xie, W.; Nangle, L.A.; Zhang, W.; Schimmel, P.; Yang, X.L.
Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase
Proc. Natl. Acad. Sci. USA
104
9976-9981
2007
Homo sapiens (P41250), Homo sapiens
Dierick, I.; Baets, J.; Irobi, J.; Jacobs, A.; De Vriendt, E.; Deconinck, T.; Merlini, L.; Van den Bergh, P.; Rasic, V.M.; Robberecht, W.; Fischer, D.; Morales, R.J.; Mitrovic, Z.; Seeman, P.; Mazanec, R.; Kochanski, A.; Jordanova, A.; Auer-Grumbach, M.; Helderman-van den Enden, A.T.; Wokke, J.H.
Relative contribution of mutations in genes for autosomal dominant distal hereditary motor neuropathies: a genotype-phenotype correlation study
Brain
131
1217-1227
2008
Homo sapiens
Chen, S.; Lin, G.; Chang, K.; Yeh, L.; Wang, C.
Translational efficiency of a non-AUG initiation codon is significantly affected by its sequence context in yeast
J. Biol. Chem.
283
3173-3180
2008
Saccharomyces cerevisiae
Motley, W.W.; Talbot, K.; Fischbeck, K.H.
GARS axonopathy: not every neurons cup of tRNA
Trends Neurosci.
33
59-66
2010
Homo sapiens, Mus musculus
Blumen, S.; Drory, V.; Sadeh, M.; El-Ad, B.; Soimu, U.; Groozman, G.; Bouchard, J.; Goldfarb, L.
Mutational analysis of glycyl-tRNA synthetase (GARS) gene in Hirayama disease
Amyotroph. Lateral Scler.
11
237-239
2010
Homo sapiens
Oberthuer, D.; Eichert, A.; Erdmann, V.A.; Fuerste, J.P.; Betzel, C.h.; Foerster, C.
The crystal structure of a Thermus thermophilus tRNAGly acceptor stem microhelix at 1.6 A resolution
Biochem. Biophys. Res. Commun.
404
245-249
2011
Thermus thermophilus
Tan, K.; Zhou, M.; Zhang, R.; Anderson, W.F.; Joachimiak, A.
The crystal structures of the alpha-subunit of the alpha2beta2 tetrameric glycyl-tRNA synthetase
J. Struct. Funct. Genomics
13
233-239
2012
Campylobacter jejuni subsp. jejuni (Q9PPK3), Campylobacter jejuni subsp. jejuni NCTC 11168 (Q9PPK3)
Wu, Y.H.; Chang, C.P.; Chien, C.I.; Tseng, Y.K.; Wang, C.C.
An insertion peptide in yeast glycyl-tRNA synthetase facilitates both productive docking and catalysis of cognate tRNAs
Mol. Cell. Biol.
33
3515-3523
2013
Saccharomyces cerevisiae (P38088), Saccharomyces cerevisiae (Q06817), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P38088)
Andreev, D.E.; Hirnet, J.; Terenin, I.M.; Dmitriev, S.E.; Niepmann, M.; Shatsky, I.N.
Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation
Nucleic Acids Res.
40
5602-5614
2012
Homo sapiens
Okamoto, K.; Kuno, A.; Hasegawa, T.
Recognition sites of glycine tRNA for glycyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1
Nucleic Acids Symp. Ser.
2005
299-300
2005
Aeropyrum pernix (Q9YBF8), Aeropyrum pernix, Aeropyrum pernix DSM 11879 (Q9YBF8)
McMillan, H.J.; Schwartzentruber, J.; Smith, A.; Lee, S.; Chakraborty, P.; Bulman, D.E.; Beaulieu, C.L.; Majewski, J.; Boycott, K.M.; Geraghty, M.T.
Compound heterozygous mutations in glycyl-tRNA synthetase are a proposed cause of systemic mitochondrial disease
BMC Med. Genet.
15
36
2014
Homo sapiens (P41250)
Qin, X.; Hao, Z.; Tian, Q.; Zhang, Z.; Zhou, C.; Xie, W.
Cocrystal structures of glycyl-tRNA synthetase in complex with tRNA suggest multiple conformational states in glycylation
J. Biol. Chem.
289
20359-20369
2014
Homo sapiens (P41250), Homo sapiens
Valencia-Sanchez, M.I.; Rodriguez-Hernandez, A.; Ferreira, R.; Santamaria-Suarez, H.A.; Arciniega, M.; Dock-Bregeon, A.C.; Moras, D.; Beinsteiner, B.; Mertens, H.; Svergun, D.; Brieba, L.G.; Grotli, M.; Torres-Larios, A.
Structural insights into the polyphyletic origins of glycyl tRNA synthetases
J. Biol. Chem.
291
14430-14446
2016
Aquifex aeolicus
Deng, X.; Qin, X.; Chen, L.; Jia, Q.; Zhang, Y.; Zhang, Z.; Lei, D.; Ren, G.; Zhou, Z.; Wang, Z.; Li, Q.; Xie, W.
Large conformational changes of insertion 3 in human glycyl-tRNA synthetase (hGlyRS) during catalysis
J. Biol. Chem.
291
5740-5752
2016
Homo sapiens (P41250), Homo sapiens
Mo, Z.; Zhang, Q.; Liu, Z.; Lauer, J.; Shi, Y.; Sun, L.; Griffin, P.R.; Yang, X.L.
Neddylation requires glycyl-tRNA synthetase to protect activated E2
Nat. Struct. Mol. Biol.
23
730-737
2016
Homo sapiens (P41250), Homo sapiens
Chien, C.I.; Chen, Y.W.; Wu, Y.H.; Chang, C.Y.; Wang, T.L.; Wang, C.C.
Functional substitution of a eukaryotic glycyl-tRNA synthetase with an evolutionarily unrelated bacterial cognate enzyme
PLoS ONE
9
e94659
2014
Arabidopsis thaliana, Saccharomyces cerevisiae, Thermus thermophilus, Homo sapiens
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