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Information on EC - DNA topoisomerase (ATP-hydrolysing)

for references in articles please use BRENDA:EC5.99.1.3

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transferred to EC
IUBMB Comments

The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC DNA topoisomerase).

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