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Information on EC 5.99.1.3 - DNA topoisomerase (ATP-hydrolysing)

for references in articles please use BRENDA:EC5.99.1.3

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transferred to EC 5.6.2.2
IUBMB Comments

The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.99.1.2 DNA topoisomerase).

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