Reference on EC 5.6.1.1 - microtubule-severing ATPase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
McNally, F.J.; Vale, R.D.
Identification of katanin, an ATPase that severs and disassembles stable microtubules
Cell
75
419-429
1993
Actinocoryne sp., Chlamydomonas reinhardtii, Spisula solidissima, Strongylocentrotus purpuratus, Xenopus laevis
McNally, F.J.; Okawa, K.; Iwamatsu, A.; Vale, R.D.
Katanin, the microtubule-severing ATPase, is concentrated at centrosomes
J. Cell Sci.
109
561-567
1996
Strongylocentrotus purpuratus, Xenopus laevis
Hartman, J.J.; Mahr, J.; McNally, K.; Okawa, K.; Iwamatsu, A.; Thomas, S.; Cheesman, S.; Heuser, J.; Vale, R.D.; McNally, F.J.
Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit
Cell
93
277-287
1998
Saccharomyces cerevisiae, Caenorhabditis elegans, Dictyostelium sp., Drosophila sp. (in: flies), Homo sapiens, Strongylocentrotus purpuratus, Xenopus laevis
Lohret, T.A.; McNally, F.J.; Quarmby, L.M.
A role for katanin-mediated axonemal severing during Chlamydomonas deflagellation
Mol. Biol.
9
1195-1207
1998
Chlamydomonas reinhardtii, Homo sapiens, Strongylocentrotus purpuratus, Xenopus laevis
McNally, F.J.; Thomas, S.
Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs
Mol. Biol.
9
1847-1861
1998
Caenorhabditis elegans, Gallus gallus, Chlamydomonas reinhardtii, Mus musculus, Strongylocentrotus purpuratus, Xenopus laevis, Homo sapiens (O75449), Homo sapiens
Lohret, T.A.; Zhao, L.; Quarmby, L.M.
Cloning of Chlamydomonas p60 katanin and localization to the site of outer doublet severing during deflagellation
Cell Motil. Cytoskeleton
43
221-231
1999
Chlamydomonas reinhardtii, Homo sapiens, Strongylocentrotus purpuratus, Xenopus laevis
Ahmad, F.J.; Yu, W.; McNally, F.J.; Baas, P.W.
An essential role for katanin in severing microtubules in the neuron
J. Cell Biol.
145
305-315
1999
Homo sapiens, Rattus norvegicus, Strongylocentrotus purpuratus
Quarmby, L.
Cellular Samurai: katanin and the severing of microtubules
J. Cell Sci.
113
2821-2827
2000
Arabidopsis sp., Caenorhabditis elegans, Chlamydomonas reinhardtii, Drosophila sp. (in: flies), Homo sapiens, no activity in Saccharomyces cerevisiae, Xenopus laevis
Stoppin-Mellet, V.; Gaillard, J.; Vantard, M.
Functional evidence for in vitro microtubule severing by the plant katanin homologue
Biochem. J.
365
337-342
2002
Arabidopsis thaliana (Q9SEX2), Arabidopsis thaliana
Davis, L.J.; Odde, D.J.; Block, S.M.; Gross, S.P.
The importance of lattice defects in katanin-mediated microtubule severing in vitro
Biophys. J.
82
2916-2927
2002
Echinoidea
McNally, K.P.; Buster, D.; McNally, F.J.
Katanin-mediated microtubule severing can be regulated by multiple mechanisms
Cell Motil. Cytoskeleton
53
337-349
2002
Xenopus laevis
Yang, H.Y.; McNally, K.; McNally, F.J.
MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C. elegans
Dev. Biol.
260
245-259
2003
Caenorhabditis elegans
Dymek, E.E.; Lefebvre, P.A.; Smith, E.F.
PF15p is the Chlamydomonas homologue of the katanin p80 subunit and is required for assembly of flagellar central microtubules
Eukaryot. Cell
3
870-879
2004
Chlamydomonas reinhardtii (Q6PLH8)
Buster, D.; McNally, K.; McNally, F.J.
Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis
J. Cell Sci.
115
1083-1092
2002
Homo sapiens
Karabay, A.; Yu, W.; Solowska, J.M.; Baird, D.H.; Baas, P.W.
Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules
J. Neurosci.
24
5778-5788
2004
Rattus norvegicus (Q6E0V2)
Roll-Mecak, A.; Vale, R.D.
The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules
Curr. Biol.
15
650-655
2005
Drosophila melanogaster
Srayko, M.; Otoole, E.T.; Hyman, A.A.; Mueller-Reichert, T.
Katanin disrupts the microtubule lattice and increases polymer number in C. elegans meiosis
Curr. Biol.
16
1944-1949
2006
Caenorhabditis elegans
Ribbeck, K.; Mitchison, T.J.
Meiotic spindle: sculpted by severing
Curr. Biol.
16
R923-R925
2006
Caenorhabditis elegans
Nurminsky, D.; Magee, C.; Faverman, L.; Nurminskaya, M.
Regulation of chondrocyte differentiation by actin-severing protein adseverin
Dev. Biol.
302
427-437
2007
Gallus gallus
Toyo-Oka, K.; Sasaki, S.; Yano, Y.; Mori, D.; Kobayashi, T.; Toyoshima, Y.Y.; Tokuoka, S.M.; Ishii, S.; Shimizu, T.; Muramatsu, M.; Hiraiwa, N.; Yoshiki, A.; Wynshaw-Boris, A.; Hirotsune, S.
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration
Hum. Mol. Genet.
14
3113-3128
2005
Mus musculus
Wood, J.D.; Landers, J.A.; Bingley, M.; McDermott, C.J.; Thomas-McArthur, V.; Gleadall, L.J.; Shaw, P.J.; Cunliffe, V.T.
The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo
Hum. Mol. Genet.
15
2763-2771
2006
Danio rerio (Q6NW58), Danio rerio
Evans, K.J.; Gomes, E.R.; Reisenweber, S.M.; Gundersen, G.G.; Lauring, B.P.
Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing
J. Cell Biol.
168
599-606
2005
Homo sapiens
Salinas, S.; Carazo-Salas, R.E.; Proukakis, C.; Cooper, J.M.; Weston, A.E.; Schiavo, G.; Warner, T.T.
Human spastin has multiple microtubule-related functions
J. Neurochem.
95
1411-1420
2005
Homo sapiens (Q9UBP0), Homo sapiens
Yu, W.; Solowska, J.M.; Qiang, L.; Karabay, A.; Baird, D.; Baas, P.W.
Regulation of microtubule severing by katanin subunits during neuronal development
J. Neurosci.
25
5573-5583
2005
Rattus norvegicus
Qiang, L.; Yu, W.; Andreadis, A.; Luo, M.; Baas, P.W.
Tau protects microtubules in the axon from severing by katanin
J. Neurosci.
26
3120-3129
2006
Rattus norvegicus
Lu, C.; Srayko, M.; Mains, P.E.
The Caenorhabditis elegans microtubule-severing complex MEI-1/MEI-2 katanin interacts differently with two superficially redundant beta-tubulin isotypes
Mol. Biol. Cell
15
142-150
2004
Caenorhabditis elegans
Schickel, J.; Beetz, C.; Froemmel, C.; Heide, G.; Sasse, A.; Hemmerich, P.; Deufel, T.
Unexpected pathogenic mechanism of a novel mutation in the coding sequence of SPG4 (spastin)
Neurology
66
421-423
2006
Homo sapiens
Stoppin-Mellet, V.; Gaillard, J.; Vantard, M.
Katanins severing activity favors bundling of cortical microtubules in plants
Plant J.
46
1009-1017
2006
Arabidopsis thaliana
Komorisono, M.; Ueguchi-Tanaka, M.; Aichi, I.; Hasegawa, Y.; Ashikari, M.; Kitano, H.; Matsuoka, M.; Sazuka, T.
Analysis of the rice mutant dwarf and gladius leaf 1. Aberrant katanin-mediated microtubule organization causes up-regulation of gibberellin biosynthetic genes independently of gibberellin signaling
Plant Physiol.
138
1982-1993
2005
Oryza sativa
Evans, K.; Keller, C.; Pavur, K.; Glasgow, K.; Conn, B.; Lauring, B.
Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance
Proc. Natl. Acad. Sci. USA
103
10666-10671
2006
Homo sapiens
Matsushita-Ishiodori, Y.; Yamanaka, K.; Ogura, T.
The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules
Biochem. Biophys. Res. Commun.
359
157-162
2007
Caenorhabditis elegans
Luo, L.; Carson, J.D.; Molnar, K.S.; Tuske, S.J.; Coales, S.J.; Hamuro, Y.; Sung, C.M.; Sudakin, V.; Auger, K.R.; Dhanak, D.; Jackson, J.R.; Huang, P.S.; Tummino, P.J.; Copeland, R.A.
Conformation-dependent ligand regulation of ATP hydrolysis by human KSP - activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator
J. Am. Chem. Soc.
130
7584-7591
2008
Homo sapiens
White, S.R.; Evans, K.J.; Lary, J.; Cole, J.L.; Lauring, B.
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing
J. Cell Biol.
176
995-1005
2007
Homo sapiens
Pantakani, D.V.; Swapna, L.S.; Srinivasan, N.; Mannan, A.U.
Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule
J. Neurochem.
106
613-624
2008
Homo sapiens
Salinas, S.; Carazo-Salas, R.E.; Proukakis, C.; Schiavo, G.; Warner, T.T.
Spastin and microtubules - Functions in health and disease
J. Neurosci. Res.
85
2778-2782
2007
Homo sapiens (Q9UBP0)
Roll-Mecak, A.; Vale, R.D.
Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin
Nature
451
363-367
2008
Drosophila melanogaster (Q8I0P1)
Mannan, A.U.; Boehm, J.; Sauter, S.M.; Rauber, A.; Byrne, P.C.; Neesen, J.; Engel, W.
Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein
Neurogenetics
7
93-103
2006
Homo sapiens
Stoppin-Mellet, V.; Gaillard, J.; Timmers, T.; Neumann, E.; Conway, J.; Vantard, M.
Arabidopsis katanin binds microtubules using a multimeric microtubule-binding domain
Plant Physiol. Biochem.
45
867-877
2007
Arabidopsis thaliana (Q9SEX2), Arabidopsis thaliana
Matsuno, K.; Sawada, J.; Sugimoto, M.; Ogo, N.; Asai, A.
Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors
Bioorg. Med. Chem. Lett.
19
1058-1061
2009
Homo sapiens
Mancuso, G.; Rugarli, E.I.
A cryptic promoter in the first exon of the SPG4 gene directs the synthesis of the 60-kDa spastin isoform
BMC Biol.
6
31
2008
Homo sapiens (Q9UBP0)
Solowska, J.M.; Morfini, G.; Falnikar, A.; Himes, B.T.; Brady, S.T.; Huang, D.; Baas, P.W.
Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia
J. Neurosci.
28
2147-2157
2008
Rattus norvegicus
Yu, W.; Qiang, L.; Solowska, J.M.; Karabay, A.; Korulu, S.; Baas, P.W.
The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches
Mol. Biol. Cell
19
1485-1498
2008
Rattus norvegicus
Connell, J.W.; Lindon, C.; Luzio, J.P.; Reid, E.
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion
Traffic
10
42-56
2009
Homo sapiens (Q9UBP0)
Matsushita-Ishiodori, Y.; Yamanaka, K.; Hashimoto, H.; Esaki, M.; Ogura, T.
Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing
Genes Cells
14
925-940
2009
Caenorhabditis elegans
Iwaya, N.; Kuwahara, Y.; Fujiwara, Y.; Goda, N.; Tenno, T.; Akiyama, K.; Mase, S.; Tochio, H.; Ikegami, T.; Shirakawa, M.; Hiroaki, H.
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization
J. Biol. Chem.
285
16822-16829
2010
Mus musculus
Zhang, D.; Grode, K.D.; Stewman, S.F.; Diaz-Valencia, J.D.; Liebling, E.; Rath, U.; Riera, T.; Currie, J.D.; Buster, D.W.; Asenjo, A.B.; Sosa, H.J.; Ross, J.L.; Ma, A.; Rogers, S.L.; Sharp, D.J.
Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration
Nat. Cell Biol.
13
361-369
2011
Drosophila melanogaster
Lumb, J.H.; Connell, J.W.; Allison, R.; Reid, E.
The AAA ATPase spastin links microtubule severing to membrane modelling
Biochim. Biophys. Acta
1823
192-197
2012
Homo sapiens
Iwaya, N.; Akiyama, K.; Goda, N.; Tenno, T.; Fujiwara, Y.; Hamada, D.; Ikura, T.; Shirakawa, M.; Hiroaki, H.
Effect of Ca2+ on the microtubule-severing enzyme p60-katanin. Insight into the substrate-dependent activation mechanism
FEBS J.
279
1339-1352
2012
Mus musculus (Q9WV86)
Eckert, T.; Link, S.; Le, D.T.; Sobczak, J.P.; Gieseke, A.; Richter, K.; Woehlke, G.
Subunit interactions and cooperativity in the microtubule-severing AAA ATPase spastin
J. Biol. Chem.
287
26278-26290
2012
Homo sapiens
Draberova, E.; Vinopal, S.; Morfini, G.; Liu, P.S.; Sladkova, V.; Sulimenko, T.; Burns, M.R.; Solowska, J.; Kulandaivel, K.; de Chadarevian, J.P.; Legido, A.; Moerk, S.J.; Janacek, J.; Baas, P.W.; Draber, P.; Katsetos, C.D.
Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation
J. Neuropathol. Exp. Neurol.
70
811-826
2011
Homo sapiens (Q9UBP0), Homo sapiens
Taylor, J.; White, S.; Lauring, B.; Kull, F.
Crystal structure of the human spastin AAA domain
J. Struct. Biol.
179
133-137
2012
Homo sapiens
Onitake, A.; Matsushita-Ishiodori, Y.; Johjima, A.; Esaki, M.; Ogura, T.; Yamanaka, K.
The C-terminal alpha-helix of SPAS-1, a Caenorhabditis elegans spastin homologue, is crucial for microtubule severing
J. Struct. Biol.
179
138-142
2012
Caenorhabditis elegans (Q8MNV0), Caenorhabditis elegans
McNally, K.; Berg, E.; Cortes, D.B.; Hernandez, V.; Mains, P.E.; McNally, F.J.
Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro
Mol. Biol. Cell
25
1037-1049
2014
Caenorhabditis elegans
Matsuo, M.; Shimodaira, T.; Kasama, T.; Hata, Y.; Echigo, A.; Okabe, M.; Arai, K.; Makino, Y.; Niwa, S.; Saya, H.; Kishimoto, T.
Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells
PLoS ONE
8
e80392
2013
Rattus norvegicus (Q6E0V2)
Bailey, M.E.; Sackett, D.L.; Ross, J.L.
Katanin severing and binding microtubules are inhibited by tubulin carboxy tails
Biophys. J.
109
2546-2561
2015
Homo sapiens (O75449), Homo sapiens, Xenopus laevis (Q9PUL2)
Joly, N.; Martino, L.; Gigant, E.; Dumont, J.; Pintard, L.
Microtubule-severing activity of the AAA+ ATPase Katanin is essential for female meiotic spindle assembly
Development
143
3604-3614
2016
Caenorhabditis elegans (P34808), Caenorhabditis elegans
Fan, X.; Lin, Z.; Fan, G.; Lu, J.; Hou, Y.; Habai, G.; Sun, L.; Yu, P.; Shen, Y.; Wen, M.; Wang, C.
The AAA protein spastin possesses two levels of basal ATPase activity
FEBS Lett.
592
1625-1633
2018
Homo sapiens (Q9UBP0)
Luptovciak, I.; Samakovli, D.; Komis, G.; Samaj, J.
KATANIN 1 is essential for embryogenesis and seed formation in Arabidopsis
Front. Plant Sci.
8
728
2017
Arabidopsis thaliana (Q9SEX2), Arabidopsis thaliana ecotype Columbia (Q9SEX2)
Nithianantham, S.; McNally, F.J.; Al-Bassam, J.
Structural basis for disassembly of katanin heterododecamers
J. Biol. Chem.
293
10590-10605
2018
Caenorhabditis elegans (P34808), Homo sapiens (Q9BW62)
Cheung, K.; Senese, S.; Kuang, J.; Bui, N.; Ongpipattanakul, C.; Gholkar, A.; Cohn, W.; Capri, J.; Whitelegge, J.P.; Torres, J.Z.
Proteomic analysis of the mammalian Katanin family of microtubule-severing enzymes defines Katanin p80 subunit B-like 1 (KATNBL1) as a regulator of mammalian Katanin microtubule-severing
Mol. Cell. Proteomics
15
1658-1669
2016
Homo sapiens (Q9BW62)
Waclawek, E.; Joachimiak, E.; Hall, M.H.; Fabczak, H.; Wloga, D.
Regulation of katanin activity in the ciliate Tetrahymena thermophila
Mol. Microbiol.
103
134-150
2017
Tetrahymena thermophila, Tetrahymena thermophila CU428.2
Grode, K.D.; Rogers, S.L.
The non-catalytic domains of Drosophila katanin regulate its abundance and microtubule-disassembly activity
PLoS ONE
10
e0123912
2015
Drosophila melanogaster (Q9VN89)
Abu-Abied, M.; Mordehaev, I.; Sunil Kumar, G.B.; Ophir, R.; Wasteneys, G.O.; Sadot, E.
Analysis of microtubule-associated-proteins during IBA-mediated adventitious root induction reveals KATANIN dependent and independent aterations of expression patterns
PLoS ONE
10
e0143828
2015
Arabidopsis thaliana (Q9SEX2), Arabidopsis thaliana ecotype Columbia (Q9SEX2)
Rezabkova, L.; Jiang, K.; Capitani, G.; Prota, A.E.; Akhmanova, A.; Steinmetz, M.O.; Kammerer, R.A.
Structural basis of katanin p60 p80 complex formation
Sci. Rep.
7
14893
2017
Mus musculus (Q9WV86 AND Q8BG40)
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