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Information on EC 5.4.99.17 - squalene-hopene cyclase

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EC Tree
     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.17 squalene-hopene cyclase
IUBMB Comments
The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129, squalene-hopanol cyclase). Hopene and hopanol are formed at a constant ratio of 5:1.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
AacSHC, cyclase, squalene-hopanoid, SHC, SHC1, SHC2, Spterp25, SQ-hopene cyclase, squalene hopene cyclase, squalene-hopene cyclase, ZmoSHC1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
squalene + H2O = hopan-22-ol
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squalene = hop-22(29)-ene
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