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Information on EC 5.4.3.7 - leucine 2,3-aminomutase
for references in articles please use BRENDA:EC5.4.3.7
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EC Tree 5 Isomerases
5.4 Intramolecular transferases
5.4.3 Transferring amino groups
5.4.3.7 leucine 2,3-aminomutase
IUBMB Comments
Requires a cobamide cofactor.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 5.4.3.7
- adenosylcobalamin
- cobalamin
-
cobalamin-dependent
- leukocytes
-
cobalamin-deficient
- analysis
showSynonyms
leucine 2,3-aminomutase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Aminomutase, leucine 2,3-
-
-
-
-
LAM
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(2S)-alpha-leucine = (3R)-beta-leucine
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
group transfer
-
-
intramolecular, amino group
-
isomerization
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
(2S)-alpha-leucine 2,3-aminomutase
Requires a cobamide cofactor.
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CAS REGISTRY NUMBER
COMMENTARY
59125-53-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-Leu
?
-
Substrates: initial step in the fermentation of Leu to acetate
Products: -
Products: -
?
alpha-Leu
?
-
Substrates: initial step in beta-keto pathway of Leu metabolism
Products: -
Products: -
?
alpha-Leu
beta-Leu
-
Substrates: (2S)-alpha-Leu
Products: (3R)-beta-Leu
Products: (3R)-beta-Leu
?
alpha-Leu
beta-Leu
-
Substrates: r
Products: i.e. 3-amino-4-methylpentanoate
Products: i.e. 3-amino-4-methylpentanoate
?
beta-Leu
?
-
Substrates: enzyme is involved in the synthesis of Leu from Val catabolites
Products: -
Products: -
?
beta-Leu
?
-
Substrates: enzyme is involved in the synthesis of Leu from Val catabolites
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-Leu
?
-
Substrates: initial step in the fermentation of Leu to acetate
Products: -
Products: -
?
alpha-Leu
?
-
Substrates: initial step in beta-keto pathway of Leu metabolism
Products: -
Products: -
?
beta-Leu
?
-
Substrates: enzyme is involved in the synthesis of Leu from Val catabolites
Products: -
Products: -
?
beta-Leu
?
-
Substrates: enzyme is involved in the synthesis of Leu from Val catabolites
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anemia, Pernicious
Cobalamin-dependent formation of leucine and beta-leucine by rat and human tissue. Changes in pernicious anemia.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity detected in rat liver using capilarry gas chromatography-mass spectrometry
-
-
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
activity is 100fold lower than in cytosol of liver
brenda
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Poston, J.M.
Leucine 2,3-aminomutase, an enzyme of leucine catabolism
J. Biol. Chem.
251
1859-1863
1976
no activity in Canis familiaris, Clostridium sporogenes, Rattus norvegicus, Ovis aries, Macaca mulatta, Chlorocebus aethiops, Homo sapiens, Gallus gallus, Clostridium cochlearium
brenda
Poston, J.M.
Leucine 2,3-aminomutase: a cobalamin-dependent enzyme present in bean seedlings
Science
195
301-302
1977
Phaseolus vulgaris
brenda
Poston, J.M.
Coenzyme B12-dependent enzymes in potatoes: leucine 2,3-aminomutase and methylmalonyl-CoA mutase
Phytochemistry
17
401-402
1978
Solanum tuberosum
-
brenda
Poston, J.M.; Hemmings, B.A.
Cobalamins and cobalamin-dependent enzymes in Candida utilis
J. Bacteriol.
140
1013-1016
1979
Cyberlindnera jadinii
brenda
Poston, J.M.
Distribution of leucine 2,3-aminomutase activity in various organs of the rat and in subcellular organelles of rat liver
Biochem. Biophys. Res. Commun.
96
838-843
1980
Rattus norvegicus
brenda
Freer, I.; Pedrocchi-Fantoni, G.; Picken, D.J.; Overton, K.H.
Stereochemistry of the leucine 2,3-aminomutase from tissue cultures of Andrographis paniculata
J. Chem. Soc. Chem. Commun.
1981
80-84
1981
Andrographis paniculata
-
brenda
Poston, J.M.
The relative carbon flux through the alpha- and the beta- keto pathways of leucine metabolism
J. Biol. Chem.
259
2059-2061
1984
Rattus norvegicus
brenda
Ward, N.E.; Jones, J.; Maurice, D.V.
Essential role of adenosylcobalamin in leucine synthesis from beta-leucine in the domestic chicken
J. Nutr.
118
159-164
1988
Gallus gallus
brenda
Poston, J.M.
beta-Leucine and the beta-keto pathway of leucine metabolism
Adv. Enzymol. Relat. Areas Mol. Biol.
58
173-189
1986
Clostridium sporogenes, Rattus norvegicus, Homo sapiens, Phaseolus vulgaris, Cyberlindnera jadinii, Andrographis paniculata, Clostridium cochlearium, Lolium sp.
brenda
Poston, J.M.
Assay of leucine 2,3-aminomutase
Methods Enzymol.
166
130-135
1988
Clostridium sporogenes, Rattus norvegicus, Homo sapiens, Solanum tuberosum, Cyberlindnera jadinii, Clostridium cochlearium, Mammalia, Spinacia oleracea
brenda
Aberhart, D.J.
Separation by high-performance liquid chromatography of alpha- and beta-amino acids: application to assays of lysine 2,3-aminomutase and leucine 2,3-aminomutase
Anal. Biochem.
169
350-355
1988
Rattus norvegicus, Mammalia
brenda
Stabler, S.P.; Lindenbaum, J.; Allen, R.H.
Failure to detect beta-leucine in human blood or leucine 2,3-aminomutase in rat liver using capillary gas chromatography-mass spectrometry
J. Biol. Chem.
263
5581-5588
1988
Rattus norvegicus
brenda
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