Information on EC 5.3.3.14 - trans-2-decenoyl-[acyl-carrier protein] isomerase and Organism(s) Homo sapiens

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Homo sapiens

The enzyme appears in selected viruses and cellular organisms

EC NUMBER
COMMENTARY hide
5.3.3.14
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RECOMMENDED NAME
GeneOntology No.
trans-2-decenoyl-[acyl-carrier protein] isomerase
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
(5Z)-dodec-5-enoate biosynthesis I
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(5Z)-dodec-5-enoate biosynthesis II
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mycolate biosynthesis
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oleate biosynthesis IV (anaerobic)
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lipid metabolism
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Fatty acid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
decenoyl-[acyl-carrier protein] Delta2-trans-Delta3-cis-isomerase
While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs [3]. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and cis-vaccenic acid, in dissociated (or type II) fatty-acid biosynthesis.
CAS REGISTRY NUMBER
COMMENTARY hide
9030-80-2
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