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Information on EC 5.3.1.5 - xylose isomerase

for references in articles please use BRENDA:EC5.3.1.5

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IUBMB Comments

Contains two divalent metal ions, preferably magnesium, located at different metal-binding sites within the active site. The enzyme catalyses the interconversion of aldose and ketose sugars with broad substrate specificity. The enzyme binds the closed form of its sugar substrate (in the case of xylose and glucose, only the α anomer ) and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. Isomerization proceeds via a hydride-shift mechanism.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
xylose isomerase, glucose isomerase, d-xylose isomerase, spezyme, xylose (glucose) isomerase, glucose/xylose isomerase, sdxyi, tthxi, tcaxi, sweetzyme, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alpha-D-xylopyranose = alpha-D-xylofuranose
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PATHWAY SOURCE
PATHWAYS
MetaCyc
D-xylose degradation I
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