Information on EC 5.1.3.7 - UDP-N-acetylglucosamine 4-epimerase and Organism(s) Homo sapiens

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Homo sapiens


The expected taxonomic range for this enzyme is: Bacteria, Eukaryota


The taxonomic range for the selected organisms is: Homo sapiens

EC NUMBER
COMMENTARY hide
5.1.3.7
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RECOMMENDED NAME
GeneOntology No.
UDP-N-acetylglucosamine 4-epimerase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
epimerization
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
teichuronic acid biosynthesis (B. subtilis 168)
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UDP-N-acetyl-D-galactosamine biosynthesis I
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UDP-N-acetyl-D-galactosamine biosynthesis II
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Amino sugar and nucleotide sugar metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-glucosamine 4-epimerase
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CAS REGISTRY NUMBER
COMMENTARY hide
9024-16-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-glucosamine
UDP-N-acetyl-D-galactosamine
show the reaction diagram
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r
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-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
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most potent activator
NADH
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stimulates to a lesser gegree than NAD+
NADP+
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stimulates to a lesser degree than NAD+
NADPH
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stimulates to a lesser degree than NAD+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-Bromo-2-hydroxy-naphthalene-1-carbaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
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IC50: 0.025 mM, specific for UDP-GlcNAc 4-epimerase, powerful reagent for reversible inhibition of O-linked glycosylation
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.011
6-Bromo-2-hydroxy-naphthalene-1-carbaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025
6-Bromo-2-hydroxy-naphthalene-1-carbaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
Homo sapiens;
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IC50: 0.025 mM, specific for UDP-GlcNAc 4-epimerase, powerful reagent for reversible inhibition of O-linked glycosylation
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 9
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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membrane
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme
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