Reference on EC 5.1.1.7 - diaminopimelate epimerase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Adams, E.
Amino acid racemases and epimerases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
6
479-507
1972
Priestia megaterium, Escherichia coli
-
Withe, P.J.; Lejeune, B.; Work, E.
Assay and properties of diaminopimelate epimerase from Bacillus megaterium
Biochem. J.
113
589-601
1969
Priestia megaterium
Tyagi, V.V.S.; Henke, R.R.; Farkas, W.R.
Occurence of diaminopimelic epimerase in maize
Biochim. Biophys. Acta
719
363-369
1982
Zea mays
-
Bartlett, A.T.M.; White, P.J.
Species of Bacillus that make a vegetative peptidoglycan containing lysine lack diaminopimelate epimerase but have diaminopimelate dehydrogenase
J. Gen. Microbiol.
131
2145-2152
1985
Geobacillus stearothermophilus, Niallia circulans, Priestia megaterium, Brevibacillus laterosporus, Paenibacillus macerans, Virgibacillus pantothenticus, Paenibacillus polymyxa, no activity in Bacillus globisporus, no activity in Bacillus pasteurii, no activity in Bacillus sphaericus
-
Wiseman, J.S.; Nichols, J.S.
Purification and properties of diaminopimelic acid epimerase from Escherichia coli
J. Biol. Chem.
259
8907-8914
1984
Escherichia coli
Richaud, C.; Higgins, W.; Mengin-Lecreulx, D.; Stragier, P.
Molecular cloning, characterization, and chromosomal localization of dapF, the Escherichia coli gene for diaminopimelate epimerase
J. Bacteriol.
169
1454-1459
1987
Escherichia coli
Chatterjee, S.P.; White, P.J.
Activities and regulation of the enzymes of lysine biosynthesis in a lysine-excreting strain of Bacillus megaterium
J. Gen. Microbiol.
128
1073-1081
1982
Priestia megaterium
-
Misono, H.; Soda, K.
Determination of meso-alpha,epsilon-diaminopimelate with meso-alpha,epsilon-diaminopimelate D-dehydrogenase
Agric. Biol. Chem.
44
2125-2128
1980
Bacteria
-
Baumann, R.J.; Bohme, E.H.; Wiseman, J.S.; Vaal, M.; Nichols, J.S.
Inhibition of Escherichia coli growth and diaminopimelic acid epimerase by 3-chlorodiaminopimelic acid
Antimicrob. Agents Chemother.
32
1119-1123
1988
Escherichia coli
Lam, L.K.P.; Arnold, L.D.; Kalantar, T.H.; Kelland, J.G.; Lane-Bell, P.M.; Palcic, M.M.; Pickard, M.A.; Vederas, J.C.
Analogs of diaminopimelic acid as inhibitors of meso-diaminopimelate dehydrogenase and LL-diaminopimelate epimerase
J. Biol. Chem.
263
11814-11819
1988
Escherichia coli
Gerhart, F.; Higgins, W.; Tardif, C.; Ducep, J.B.
2-(4-Amino-4-carboxybutyl)aziridine-2-carboxylic acid. A potent irreversible inhibitor of diaminopimelic acid epimerase. Spontaneous formation from alpha-(halomethyl)diaminopimelic acids
J. Med. Chem.
33
2157-2162
1990
Escherichia coli
Weir, A.N.C.; Bucke, C.; Holt, G.; Lilly, M.D.; Bull, A.T.
A high-performance liquid chromatography method for the simultaneous assay of diaminopimelate epimerase and decarboxylase
Anal. Biochem.
180
298-302
1989
Bacillus subtilis
Gelb, M.H.; Lin, Y.; Pickard, M.A.; Song, Y.; Vederas, J.C.
Synthesis of 3-fluorodiaminopimelic acid isomers as inhibitors of diaminopimelate epimerase: stereocontrolled enzymatic elimination of hydrogen fluoride
J. Am. Chem. Soc.
112
4932-4942
1990
Escherichia coli
-
Abbott, S.D.; Lane-Bell, P.; Sidhu, K.P.S.; Vederas, J.C.
Synthesis and testing of heterocyclic analogues of diaminopimelic acid (DAP) as inhibitors of DAP dehydrogenase and DAP epimerase
J. Am. Chem. Soc.
116
6513-6520
1994
Escherichia coli
-
Song, Y.; Niederer, D.; Lane-Bell, P.M.; Lam, L.K.P.; Crawley, S.; Palcic, M.M.; Pickard, M.A.; Pruess, D.L.; Vederas, J.C.
Stereospecific synthesis of phosphonate analogues of diaminopimelic acid (DAP), their interaction with DAP enzymes and antibacterial activity of peptide derivatives
J. Org. Chem.
59
5784-5793
1994
Escherichia coli
-
Schrumpf, B.; Schwarzer, A.; Kalinowski, J.; Puhler, A.; Eggeling, L.; Sahm, H.
A functionally split pathway for lysine synthesis in Corynebacterium glutamicum
J. Bacteriol.
173
4510-4516
1991
Bacillus subtilis, Corynebacterium glutamicum, Escherichia coli, no activity in Bacillus sphaericus
El-Waziry, A.M.; Onodera, R.
In vitro metabolism of the stereoisomers of 2,6-diaminopimelic acid by mixed rumen protozoa and bacteria
Curr. Microbiol.
33
306-311
1996
unclassified Bacteria
Chatterjee, S.P.; Singh, B.K.; Gilvarg, C.
Biosynthesis of lysine in plants: the putative role of meso-diaminopimelate dehydrogenase
Plant Mol. Biol.
26
285-290
1994
Chlamydomonas sp., Glycine max, Nicotiana tabacum, Zea mays
Chatterjee, M.
Lysine production by Brevibacterium linens and its mutants: activities and regulation of enzymes of the lysine biosynthetic pathway
Folia Microbiol. (Praha)
43
141-146
1998
Brevibacterium linens
Scapin, G.; Blanchard, J.S.
Enzymology of bacterial lysine biosynthesis
Adv. Enzymol. Relat. Areas Mol. Biol.
72
279-324
1998
Escherichia coli
Koo, C.W.; Sutherland, A.; Vederas, J.C.; Blanchard, J.S.
Identification of active site cysteine residues that function as general bases: diaminopimelate epimerase
J. Am. Chem. Soc.
122
6122-6123
2000
Haemophilus influenzae
-
Caplan, J.F.; Zheng, R.; Blanchard, J.S.; Vederas, J.C.
Vinylogous amide analogues of diaminopimelic acid (DAP) as inhibitors of enzymes involved in bacterial lysine biosynthesis
Org. Lett.
2
3857-3860
2000
Escherichia coli
Lloyd, A.J.; Huyton, T.; Turkenburg, J.; Roper, D.I.
Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 A resolution suggests a mechanism for stereocontrol during catalysis
Acta Crystallogr. Sect. D
60
397-400
2004
Haemophilus influenzae
Grassick, A.; Sulzenbacher, G.; Roig-Zamboni, V.; Campanacci, V.; Cambillau, C.; Bourne, Y.
Crystal structure of E. coli YddE protein reveals a striking homology with diaminopimelate epimerase
Proteins
55
764-767
2004
Escherichia coli
Pillai, B.; Cherney, M.; Diaper, C.M.; Sutherland, A.; Blanchard, J.S.; Vederas, J.C.; James, M.N.
Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase
Biochem. Biophys. Res. Commun.
363
547-553
2007
Haemophilus influenzae (P44859), Haemophilus influenzae
Usha, V.; Dover, L.G.; Roper, D.L.; Lloyd, A.J.; Besra, G.S.
Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase
FEMS Microbiol. Lett.
262
39-47
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Brunetti, L.; Galeazzi, R.; Orena, M.; Bottoni, A.
Catalytic mechanism of l,l-diaminopimelic acid with diaminopimelate epimerase by molecular docking simulations
J. Mol. Graph. Model.
26
1082-1090
2008
Haemophilus influenzae
Pillai, B.; Cherney, M.M.; Diaper, C.M.; Sutherland, A.; Blanchard, J.S.; Vederas, J.C.; James, M.N.
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target
Proc. Natl. Acad. Sci. USA
103
8668-8673
2006
Haemophilus influenzae (P44859), Haemophilus influenzae
Usha, V.; Dover, L.G.; Roper, D.L.; Besra, G.S.
Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization
FEMS Microbiol. Lett.
280
57-63
2008
Mycobacterium tuberculosis (P9WP19), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WP19)
Pillai, B.; Moorthie, V.A.; van Belkum, M.J.; Marcus, S.L.; Cherney, M.M.; Diaper, C.M.; Vederas, J.C.; James, M.N.
Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for l-lysine biosynthesis
J. Mol. Biol.
385
580-594
2009
Arabidopsis thaliana (Q9LFG2), Arabidopsis thaliana
Usha, V.; Dover, L.G.; Roper, D.I.; Fuetterer, K.; Besra, G.S.
Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis
Acta Crystallogr. Sect. D
65
383-387
2009
Mycobacterium tuberculosis (P9WP19), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WP19)
Hor, L.; Dobson, R.; Dogovski, C.; Hutton, C.; Perugini, M.
Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli
Acta Crystallogr. Sect. F
66
37-40
2009
Escherichia coli
Stenta, M.; Calvaresi, M.; Alto, P.; Spinelli, D.; Garavelli, M.; Galeazzi, R.; Bottoni, A.
Catalytic mechanism of diaminopimelate epimerase: A QM/MM investigation
J. Chem. Theory Comput.
5
1915-1930
2009
Haemophilus influenzae (P44859)
Park, J.; Lee, W.; Song, J.; Kim, S.; Lee, J.; Cheong, C.; Kim, H.
Purification, crystallization and preliminary X-ray crystallographic analysis of diaminopimelate epimerase from Acinetobacter baumannii
Acta Crystallogr. Sect. F
69
42-44
2013
Acinetobacter baumannii
Hor, L.; Dobson, R.; Downton, M.; Wagner, J.; Hutton, C.; Perugini, M.
Dimerization of bacterial diaminopimelate epimerase is essential for catalysis
J. Biol. Chem.
288
9238-9248
2013
Escherichia coli
Miura, H.; Hori, K.; Sasaki, Y.; Inahashi, Y.; Yagisawa, Y.; Fujita, N.; Omura, S.; Takahashi, Y.
Simple analytic method of diaminopimelate epimerase activity
J. Biosci. Bioeng.
116
253-255
2013
Kitasatospora setae (E4NI20), Kitasatospora setae KM-6054 (E4NI20)
Liechti, G.; Singh, R.; Rossi, P.; Gray, M.; Adams, N.; Maurelli, A.
Chlamydia trachomatis dapF encodes a bifunctional enzyme capable of both D-glutamate racemase and diaminopimelate epimerase activities
mBio
9
e00204-18
2018
Chlamydia trachomatis
Sagong, H.Y.; Kim, K.J.
Structural basis for redox sensitivity in Corynebacterium glutamicum diaminopimelate epimerase an enzyme involved in L-lysine biosynthesis
Sci. Rep.
7
42318
2017
Corynebacterium glutamicum (Q8NP73), Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 (Q8NP73)
html completed
