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Information on EC 4.99.1.8 - heme ligase

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EC Tree
     4 Lyases
         4.99 Other lyases
             4.99.1 Sole sub-subclass for lyases that do not belong in the other subclasses
                4.99.1.8 heme ligase
IUBMB Comments
This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin. These organisms lack the mammalian heme oxygenase for elimination of heme.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
alpha-HDP, HDP, heme detoxification protein, heme-detoxification protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 ferriprotoporphyrin IX = beta-hematin
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PATHWAY SOURCE
PATHWAYS
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