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Information on EC 4.4.1.25 - L-cysteate sulfo-lyase

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IUBMB Comments
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogensulfite and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. D-Cysteine can also act as a substrate, but more slowly. It is converted into hydrogen sulfide, pyruvate, and ammonia. This inducible enzyme from the marine bacterium Silicibacter pomeroyi DSS-3 forms part of the cysteate-degradation pathway.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
(S)-cysteate sulfo-lyase, CuyA, cysteate sulfo-lyase, L-cysteate sulpho-lyase (deaminating), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-aminoprop-2-enoate = 2-iminopropanoate
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spontaneous
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2-iminopropanoate + H2O = pyruvate + NH3
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spontaneous
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L-cysteate + H2O = hydrogensulfite + pyruvate + NH3
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overall reaction
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L-cysteate = hydrogensulfite + 2-aminoprop-2-enoate
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(1a)
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