Reference on EC 4.4.1.20 - leukotriene-C4 synthase
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Sala, A.; Garcia, M.; Zarini, S.; Rossi, J.C.; Folco, G.; Durand, T.
14,15-dehydroleukotriene A4: a specific substrate for leukotriene C4 synthase
Biochem. J.
328
225-229
1997
Homo sapiens
-
Penrose, J.F.
LTC4 synthase: Enzymology, biochemistry, and molecular characterization
Clin. Rev. Allergy Immunol.
17
133-152
1999
Homo sapiens
Penrose, J.F.; Austen, K.F.
The biochemical, molecular, and genomic aspects of leukotriene C4 synthase
Proc. Assoc. Am. Phys.
111
537-546
1999
Cavia porcellus, Homo sapiens, Mus musculus
-
Hevko, J.M.; Murphy, R.C.
Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase
J. Biol. Chem.
277
7037-7043
2002
Mus musculus
Sjostrom, M.; Jakobsson, P.J.; Juremalm, M.; Ahmed, A.; Nilsson, G.; Macchia, L.; Haeggstrom, J.Z.
Human mast cells express two leukotriene C4 synthase isoenzymes and the CysLT1 receptor
Biochim. Biophys. Acta
1583
53-62
2002
Homo sapiens
Gupta, N.; Gresser, M.J.; Ford-Hutchinson, A.W.
Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase
Biochim. Biophys. Acta
1391
157-168
1998
Homo sapiens
Söderström, M.; Hammarström, S.; Mannervik, B.
Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases
Biochem. J.
250
713-718
1988
Mus musculus
Christmas, P.; Weber, B.M.; McKee, M.; Brown, D.; Soberman, R.J.
Membrane localization and topology of leukotriene C4 synthase
J. Biol. Chem.
277
28902-28908
2002
Homo sapiens
Nicholson, D.W.; Ali, A.; Vaillancourt, J.P.; Calaycay, J.R.; Mumford, R.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.
Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits
Proc. Natl. Acad. Sci. USA
90
2015-2019
1993
Homo sapiens
Nicholson, D.W.; Ali, A.; Klemba, M.W.; Munday, N.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.
Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells
J. Biol. Chem.
267
17849-17857
1992
Homo sapiens, Rattus norvegicus
Abe, M.; Hugli, T.E.
Characterization of leukotriene C4 synthetase in mouse peritoneal exudate cells
Biochim. Biophys. Acta
959
386-398
1988
Mus musculus
Soederstroem, M.; Morgenstern, R.; Hammarstroem, S.
Protein-protein interaction affinity chromatography of leukotriene C4 synthase
Protein Expr. Purif.
6
352-356
1995
Homo sapiens, Mus musculus
Izumi, T.; Honda, Z.; Ohishi, N.; Kitamura, S.; Tsuchida, S.; Sato, K.; Shimizu, T.; Seyama, Y.
Solubilization and partial purification of leukotriene C4 synthase from guinea-pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4
Biochim. Biophys. Acta
959
305-315
1988
Cavia porcellus, Rattus norvegicus
Goppelt-Struebe, M.
Two step purification of human and murine leukotriene C4 synthase
Biochim. Biophys. Acta
1256
257-261
1995
Homo sapiens, Mus musculus
Söderström, M.; Mannervik, B.; Garkov, V.; Hammarström, S.
On the nature of leukotriene C4 synthase in human platelets
Arch. Biochem. Biophys.
294
70-74
1992
Homo sapiens
Lam, B.K.; Frank Austen, K.
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes
Prostaglandins Other Lipid Mediat.
68-69
511-520
2002
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
Yoshimoto, T.; Soberman, R.J.; Lewis, R.A.; Austen, K.F.
Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells
Proc. Natl. Acad. Sci. USA
82
8399-8403
1985
Rattus norvegicus
Tornhamre, S.; Sjolinder, M.; Lindberg, A.; Ericsson, I.; Nasman-Glaser, B.; Griffiths, W.J.; Lindgren, J.A.
Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity
Eur. J. Biochem.
251
227-235
1998
Bos taurus, Oryctolagus cuniculus, Equus caballus, Ovis aries, Homo sapiens, no activity in Sus scrofa, Rattus norvegicus
Wu, C.
Conversion of leukotrienes A4 to C4 in cell-free systems
Biochem. Biophys. Res. Commun.
134
85-92
1986
Cavia porcellus, Homo sapiens, Rattus norvegicus
Penrose, J.F.; Gagnon, L.; Goppelt-Struebe, M.; Myers, P.; Lam, B.K.; Jack, R.M.; Austen, K.F.; Soberman, R.J.
Purification of human leukotriene C4 synthase
Proc. Natl. Acad. Sci. USA
89
11603-11606
1992
Homo sapiens
Nicholson, D.W.; Klemba, M.W.; Rasper, D.M.; Metters, K.M.; Zamboni, R.J.
Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells
Eur. J. Biochem.
209
725-734
1992
Homo sapiens
Soberman, R.J.; Yoshimoto, T.
Leukotriene C4 synthase from rat basophilic leukemia cell microsomes
Methods Enzymol.
163
353-357
1988
Rattus norvegicus
Soberman, R.J.
Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes
Methods Enzymol.
187
335-337
1990
Cavia porcellus
Söderström, M.; Mannervik, B.; Mammarström, S.
Leukotriene C4 synthase: characterization in mouse mastocytoma cells
Methods Enzymol.
187
306-312
1990
Mus musculus
Lam, B.K.; Penrose, J.F.; Rokach, J.; Xu, K.; Baldasaro, M.H.; Austen, K.F.
Molecular cloning, expression and characterization of mouse leukotriene C4 synthase
Eur. J. Biochem.
238
606-612
1996
Homo sapiens, Mus musculus
Bach, M.K.; Brashler, J.R.; Morton, D.R.
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase
Arch. Biochem. Biophys.
230
455-465
1984
Rattus norvegicus
Petric, R.; Nicholson, D.W.; Ford-Hutchinson, A.W.
Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis
Biochim. Biophys. Acta
1254
207-215
1995
Rattus norvegicus
Schroder, O.; Sjostrom, M.; Qiu, H.; Stein, J.; Jakobsson, P.J.; Haeggstrom, J.Z.
Molecular and catalytic properties of three rat leukotriene C4 synthase homologs
Biochem. Biophys. Res. Commun.
312
271-276
2003
Rattus norvegicus (Q925U2)
Svartz, J.; Blomgran, R.; Hammarstrom, S.; Soderstrom, M.
Leukotriene C4 synthase homo-oligomers detected in living cells by bioluminescence resonance energy transfer
Biochim. Biophys. Acta
1633
90-95
2003
Homo sapiens (Q16873), Homo sapiens
Schroder, O.; Sjostrom, M.; Qiu, H.; Jakobsson, P.J.; Haeggstrom, J.Z.
Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis
Cell. Mol. Life Sci.
62
87-94
2005
Rattus norvegicus
Yoshikawa, K.; Matsui, E.; Kaneko, H.; Fukao, T.; Inoue, R.; Teramoto, T.; Shinoda, S.; Fukutomi, O.; Aoki, M.; Kasahara, K.; Kondo, N.
A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases
Int. J. Mol. Med.
16
827-831
2005
Homo sapiens (Q16873), Homo sapiens
Zaitsu, M.; Hamasaki, Y.; Matsuo, M.; Ichimaru, T.; Fujita, I.; Ishii, E.
Leukotriene synthesis is increased by transcriptional up-regulation of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene C4 synthase in asthmatic children
J. Asthma
40
147-154
2003
Homo sapiens (Q16873), Homo sapiens
Abe, M.; Shibata, K.; Urata, H.; Sakata, N.; Katsuragi, T.
Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone
J. Cell. Physiol.
196
154-164
2003
Rattus norvegicus
Mansour, M.; Tornhamre, S.
Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone
J. Enzyme Inhib. Med. Chem.
19
431-436
2004
Homo sapiens (Q16873), Homo sapiens
Shimada, A.; Satoh, M.; Chiba, Y.; Saitoh, Y.; Kawamura, N.; Keino, H.; Hosokawa, M.; Shimizu, T.
Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain
Neuroscience
131
683-689
2005
Mus musculus (Q60860), Mus musculus
Mandal, A.K.; Skoch, J.; Bacskai, B.J.; Hyman, B.T.; Christmas, P.; Miller, D.; Yamin, T.t.D.; Xu, S.; Wisniewski, D.; Evans, J.F.; Soberman, R.J.
The membrane organization of leukotriene synthesis
Proc. Natl. Acad. Sci. USA
101
6587-6592
2004
Homo sapiens (Q16873)
Lam, B.K.
Leukotriene C4 synthase
Prostaglandins Leukot. Essent. Fatty Acids
69
111-116
2003
Homo sapiens (Q16873)
Schmidt-Krey, I.; Kanaoka, Y.; Mills, D.J.; Irikura, D.; Haase, W.; Lam, B.K.; Austen, K.F.; Kuehlbrandt, W.
Human leukotriene C4 synthase at 4.5.ANG. resolution in projection
Structure
12
2009-2014
2004
Homo sapiens (Q16873)
Serio, K.J.; Luo, C.; Luo, L.; Mao, J.T.
TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes
Am. J. Physiol.
292
L215-L222
2007
Homo sapiens (Q16873), Homo sapiens
Serio, K.J.; Luo, C.; Luo, L.; Mao, J.T.
TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes
Am. J. Physiol. Lung Cell Mol. Physiol.
292
L215-L222
2007
Mus musculus (Q60860), Mus musculus
Strid, T.; Soederstroem, M.; Hammarstroem, S.
Leukotriene C4 synthase promoter driven expression of GFP reveals cell specificity
Biochem. Biophys. Res. Commun.
366
80-85
2008
Mus musculus (Q60860), Mus musculus
Yang, S.L.; Lou, Y.J.
Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats
Biochem. Pharmacol.
73
724-735
2007
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Mastalerz, L.; Setkowicz, M.; Sanak, M.; Rybarczyk, H.; Szczeklik, A.
Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant
Br. J. Dermatol.
154
256-260
2006
Homo sapiens (Q16873), Homo sapiens
Jame, A.J.; Lackie, P.M.; Cazaly, A.M.; Sayers, I.; Penrose, J.F.; Holgate, S.T.; Sampson, A.P.
Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4
Clin. Exp. Allergy
37
880-892
2007
Homo sapiens (Q16873), Homo sapiens
Svartz, J.; Hallin, E.; Shi, Y.; Soederstroem, M.; Hammarstroem, S.
Identification of regions of leukotriene C4 synthase which direct the enzyme to its nuclear envelope localization
J. Cell. Biochem.
98
1517-1527
2006
Homo sapiens (Q16873), Homo sapiens
Ago, H.; Kanaoka, Y.; Irikura, D.; Lam, B.K.; Shimamura, T.; Austen, K.F.; Miyano, M.
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
Nature
448
609-612
2007
Homo sapiens (Q16873), Homo sapiens
Martinez Molina, D.; Wetterholm, A.; Kohl, A.; McCarthy, A.A.; Niegowski, D.; Ohlson, E.; Hammarberg, T.; Eshaghi, S.; Haeggstroem, J.Z.; Nordlund, P.
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase
Nature
448
613-616
2007
Homo sapiens (Q16873), Homo sapiens
Freiberg, J.J.; Tybjaerg-Hansen, A.; Sillesen, H.; Jensen, G.B.; Nordestgaard, B.G.
Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease
Arterioscler. Thromb. Vasc. Biol.
28
990-996
2008
Homo sapiens
Ma, K.; Zhang, Y.; Zhu, D.; Lou, Y.
Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway
Eur. J. Pharmacol.
603
98-107
2009
Rattus norvegicus
Sveinbjoernsson, B.; Rasmuson, A.; Baryawno, N.; Wan, M.; Pettersen, I.; Ponthan, F.; Orrego, A.; Haeggstroem, J.Z.; Johnsen, J.I.; Kogner, P.
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
FASEB J.
22
3525-3536
2008
Homo sapiens
Wetterholm, A.; Martinez Molina, D.; Nordlund, P.; Eshaghi, S.; Haeggstroem, J.Z.
High-level expression, purification, and crystallization of recombinant rat leukotriene C4 synthase from the yeast Pichia pastoris
Protein Expr. Purif.
60
1-6
2008
Rattus norvegicus
Bevan, S.; Dichgans, M.; Wiechmann, H.E.; Gschwendtner, A.; Meitinger, T.; Markus, H.S.
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations
Stroke
39
1109-1114
2008
Homo sapiens
Ma, K.F.; Yang, H.Y.; Chen, Z.; Qi, L.Y.; Zhu, D.Y.; Lou, Y.J.
Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model
World J. Gastroenterol.
14
2748-2756
2008
Rattus norvegicus
Strid, T.; Svartz, J.; Franck, N.; Hallin, E.; Ingelsson, B.; Soederstroem, M.; Hammarstroem, S.
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein
Biochem. Biophys. Res. Commun.
381
518-522
2009
Homo sapiens (Q16873)
Westergren, V.S.; Wilson, S.J.; Penrose, J.F.; Howarth, P.H.; Sampson, A.P.
Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis
Clin. Exp. Allergy
39
820-828
2009
Homo sapiens (Q16873)
Okubo, M.; Yamanaka, H.; Kobayashi, K.; Noguchi, K.
Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain
Glia
58
599-610
2010
Rattus norvegicus (Q925U2)
Steinke, J.W.; Culp, J.A.; Kropf, E.; Borish, L.
Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization
J. Allergy Clin. Immunol.
124
724-730
2009
Homo sapiens (Q16873)
Newcomer, M.E.; Gilbert, N.C.
Location, location, location: compartmentalization of early events in leukotriene biosynthesis
J. Biol. Chem.
285
25109-25114
2010
Homo sapiens (Q16873)
Sanchez-Borges, M.; Acevedo, N.; Vergara, C.; Jimenez, S.; Zabner-Oziel, P.; Monzon, A.; Caraballo, L.
The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria
J. Investig. Allergol. Clin. Immunol.
19
375-382
2009
Homo sapiens
Freiberg, J.J.; Dahl, M.; Tybjaerg-Hansen, A.; Grande, P.; Nordestgaard, B.G.
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals
J. Mol. Cell. Cardiol.
46
579-586
2009
Homo sapiens (Q16873), Homo sapiens
Zhao, G.; Johnson, M.C.; Schnell, J.R.; Kanaoka, Y.; Haase, W.; Irikura, D.; Lam, B.K.; Schmidt-Krey, I.
Two-dimensional crystallization conditions of human leukotriene C4 synthase requiring adjustment of a particularly large combination of specific parameters
J. Struct. Biol.
169
450-454
2010
Homo sapiens
Esser, J.; Gehrmann, U.; Salvado, M.D.; Wetterholm, A.; Haeggstroem, J.Z.; Samuelsson, B.; Gabrielsson, S.; Scheynius, A.; Radmark, O.
Zymosan suppresses leukotriene C4 synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors
FASEB J.
25
1417-1427
2011
Homo sapiens
Rinaldo-Matthis, A.; Wetterholm, A.; Martinez Molina, D.; Holm, J.; Niegowski, D.; Ohlson, E.; Nordlund, P.; Morgenstern, R.; Haeggstroem, J.Z.
Arginine 104 is a key catalytic residue in leukotriene C4 synthase
J. Biol. Chem.
285
40771-40776
2010
Homo sapiens (Q16873), Homo sapiens
Saino, H.; Ukita, Y.; Ago, H.; Irikura, D.; Nisawa, A.; Ueno, G.; Yamamoto, M.; Kanaoka, Y.; Lam, B.K.; Austen, K.F.; Miyano, M.
The catalytic architecture of leukotriene C4 synthase with two arginine residues
J. Biol. Chem.
286
16392-16401
2011
Homo sapiens (Q16873)
Freiberg, J.J.; Tybjaerg-Hansen, A.; Nordestgaard, B.G.
Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals
J. Thromb. Haemost.
8
1694-1701
2010
Homo sapiens
Di Gennaro, A.; Wagsaeter, D.; Maeyraenpaeae, M.I.; Gabrielsen, A.; Swedenborg, J.; Hamsten, A.; Samuelsson, B.; Eriksson, P.; Haeggstroem, J.Z.
Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm
Proc. Natl. Acad. Sci. USA
107
21093-21097
2010
Homo sapiens
Niegowski, D.; Kleinschmidt, T.; Olsson, U.; Ahmad, S.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism
J. Biol. Chem.
289
5199-5207
2014
Homo sapiens (Q16873), Homo sapiens
MacDonald, C.A.; Bushnell, E.A.; Gauld, J.W.; Boyd, R.J.
The catalytic formation of leukotriene C4: a critical step in inflammatory processes
Phys. Chem. Chem. Phys.
16
16284-16289
2014
Homo sapiens
Niegowski, D.; Kleinschmidt, T.; Ahmad, S.; Qureshi, A.A.; Marback, M.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
Structure and inhibition of mouse leukotriene C4 synthase
PLoS ONE
9
e96763
2014
Mus musculus (Q60860), Mus musculus
Liening, S.; Scriba, G.K.; Rummler, S.; Weinigel, C.; Kleinschmidt, T.K.; Haeggstroem, J.Z.; Werz, O.; Garscha, U.
Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors
Biochim. Biophys. Acta
1861
1605-1613
2016
Homo sapiens (Q16873)
Hong, F.F.; Wang, Y.F.; Liu, H.; Yang, M.W.; Yang, S.L.
V-PYRRO/NO downregulates mRNA expression levels of leukotriene C4 synthase during hepatic ischemia reperfusion injury in rats via inhibition of the nuclear factor-kappaB activation pathway
Biomed. Rep.
4
112-116
2016
Rattus norvegicus (G3V6E6)
Ahmad, S.; Ytterberg, A.J.; Thulasingam, M.; Tholander, F.; Bergman, T.; Zubarev, R.; Wetterholm, A.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
Phosphorylation of leukotriene C4 synthase at serine 36 impairs catalytic activity
J. Biol. Chem.
291
18410-18418
2016
Homo sapiens (Q16873)
Kleinschmidt, T.K.; Haraldsson, M.; Basavarajappa, D.; Lundeberg, E.; Thulasingam, M.; Ekoff, M.; Fauland, A.; Lehmann, C.; Kahnt, A.S.; Lindbom, L.; Haeggstroem, J.Z.
Tandem benzophenone amino pyridines, potent and selective inhibitors of human leukotriene C4 synthase
J. Pharmacol. Exp. Ther.
355
108-116
2015
Homo sapiens (Q16873), Homo sapiens
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