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(H2N)2Pt(Cl)SCH2CH(NH3+)CO2- + H2O
CH3C(O)CO2- + NH4+ + (NH2)2Pt(Cl)SH
(S)-1,1,2,2-tetrafluoroethyl-L-cysteine + H2O
? + NH3 + pyruvate
-
-
-
-
?
(S)-2,4-dinitrophenyl-L-cysteine
2,4-dinitrobenzenethiol + pyruvate + NH3
(S)-2,4-dinitrophenyl-L-homocysteine
?
-
-
-
-
?
(S)-2-benzothiazolyl-L-cysteine
pyruvate + NH3 + 2-mercaptobenzothiazole
(S)-2-benzothiazolyl-L-cysteine + H2O
pyruvate + NH3 + 2-mercaptobenzothiazole
-
-
-
-
?
(S)-4-(4-methylpentan-2-one)-L-cysteine + H2O
4-mercapto-4-methylpentan-2-one + NH3 + pyruvate
-
Str3p is able to release 0.0123 mM 4-mercapto-4-methylpentan-2-one from 2 mM concentration of its precursor S-(2-methyl-4-oxopentan-2-yl)-L-cysteine
-
?
(S)-4-bromophenyl-L-cysteine
p-bromobenzenethiol + NH3 + pyruvate
(S)-4-nitrobenzyl-L-cysteine
?
-
-
-
-
?
(S)-methylcysteine + H2O
methanethiol + pyruvate + NH3
2,4-dinitrophenyl-L-cysteine + H2O
2,4-dinitrobenzenethiol + pyruvate + NH3
2-(2-(S)-L-cysteinylpentyl)-1,3-thiazolidine-4-carboxylic acid
3-mercaptohexanal + ?
-
-
-
?
3-cysteinylhexanol
3-mercaptohexanal + ?
3-hydroxykynurenine
?
-
-
-
-
?
3-S-(N-acetyl-L-cysteinyl)-hexanal
3-mercaptohexanal + ?
3-S-L-cysteinylhexanal
3-mercaptohexanal + ?
4,5-epoxy-4,5-dihydro-1-nitropyrene
?
-
-
-
-
?
5'-S-cysteinyldopamine
?
-
-
-
-
?
5-S-L-cysteinyldopamine
pyruvate + ?
-
slow beta-elimination reaction
-
-
?
8-S-cysteinyl-p-menthan-3-one
8-mercapto-p-menthan-3-one
-
-
-
?
9,10-epoxy-9,10-dihydro-1-nitropyrene
?
-
-
-
-
?
alanine derivatives
?
-
-
-
-
?
alpha-keto-gamma-methiobutyric acid + L-aspartate
?
Monieza expansa
-
transamination reaction
-
?
benzothiazolyl-L-cysteine
?
benzyl-L-cysteine
?
-
-
-
?
beta-chloro-DL-alanine
?
-
-
-
-
?
beta-chloro-L-alanine
?
-
-
-
?
beta-chloroalanine
?
-
-
-
-
?
cystathionine + H2O
homocysteine + pyruvate + NH3
-
-
-
?
cystathionine + H2O
L-homocysteine + NH3 + pyruvate
cystathionine + H2O
L-homocysteine + pyruvate + NH3
cysteine thioethers
?
-
-
-
-
?
D-cystine + H2O
?
-
2% of the activity with L-cystine
-
?
DL-homocysteine + H2O
hydrogen sulfide + 2-oxobutyrate + ?
homoserine + H2O
?
-
96% of the activity with L-cystathionine
-
-
?
L-cystathionine
L-homocysteine + pyruvate + NH4+
L-cystathionine + H2O
cysteine + ?
-
alpha,gamma-elimination
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
L-cysteine + H2O
hydrogen sulfide + pyruvate + ?
L-cysteine + H2O
pyruvate + NH3 + hydrogen sulfide
L-cysteine + H2O
sulfide + NH3 + pyruvate
L-cysteine S-sulfate + H2O
?
-
11% of the activity with L-cystine
-
?
L-cysteine-S-sulphate
?
-
-
-
?
L-cystine + H2O
?
22% activity compared to L-cystathionine
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
L-cystine + H2O
pyruvate + NH3 + L-thiocysteine
-
-
-
-
?
L-djenkolate
pyruvate + NH3 + S-(mercaptomethyl)cysteine
L-djenkolate + H2O
pyruvate
L-djenkolate + H2O
pyruvate + NH3 + ?
most effective substrate, 154% activity compared to L-cystathionine
-
-
?
L-djenkolate sulphoxide
?
-
-
-
?
L-djenkolic acid + H2O
?
-
18-24% of the activity with L-cystine, depending on assay method
-
?
L-homolanthionine + H2O
?
-
-
-
-
?
L-leucine + alpha-ketoglutarate
?
-
-
-
?
L-meso-lanthionine + H2O
?
-
-
-
-
?
L-methionine
methanethiol + (2S)-2-aminobutanoic acid
-
-
-
-
?
L-methionine + H2O
methanethiol + dimethyl disulfide + dimethyl trisulfide + 2-oxobutyrate
L-methionine + H2O
methanethiol + NH3 + 2-oxobutanoate
L-selenocystathionine + H2O
?
L-Selenodjenkolate
Se-(hydroselenomethyl)selenocysteine + pyruvate + NH3
L-selenomethionine
HSe(CH3) + NH3 + 2-oxobutanoate
-
-
-
?
L-serine + H2O
hydrogen sulfide + pyruvate + NH3
MalY
-
-
?
lanthionine + H2O
L-cysteine + NH3 + pyruvate
leukotriene E4
?
-
-
-
-
?
mixed disulfide of L-cysteine and L-homocysteine + H2O
?
-
-
-
-
?
O-acetyl-L-serine + H2O
acetate + pyruvate + NH3
-
-
-
?
O-methyl-DL-serine
?
-
-
-
?
O-succinyl-L-homoserine + H2O
2-oxobutyrate + succinate + NH3
MetC
-
-
?
p-nitrobenzyl-L-cysteine
?
RS-CH2-CH(NH3+)COO- + H2O
RSH + NH3 + pyruvate
RSH-CH2-CH(NH3+)COO-
RSH + NH3 + pyruvate
RSH-CH2-CH(NH3+)COO- + H2O
RSH + NH3 + pyruvate
-
-
-
-
?
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
?
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
NH3 + pyruvate + 1,1,2,2-tetrafluoroethanethiol
-
-
-
-
?
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O
NH3 + pyruvate + 1,1,2,2-tetrafluoroethanethiol
-
-
-
-
ir
S-(1,1,2-trichlorovinyl)-L-cysteine
?
Monieza expansa
-
-
-
?
S-(1,2-dichloroethenyl)-L-cysteine + H2O
pyruvate + NH3 + dichlorovinyl mercaptane
-
-
-
-
?
S-(1,2-dichlorovinyl)-L-cysteine
?
S-(1,2-dichlorovinyl)-L-cysteine + H2O
NH3 + pyruvate + 1,2-dichloroethylenethiol
S-(1-hydroxyhexan-3-yl)-L-cysteine + H2O
3-mercaptohexan-1-ol + NH3 + pyruvate
-
Str3p is able to release 0.0021 mM 3-mercaptohexan-1-ol from 2 mM concentrations of its precursor (S)-3-(hexan-1-ol)-L-cysteine
-
?
S-(2-aminoethyl)-L-Cys + H2O
?
-
-
-
-
?
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
?
S-(E-1,2-Dichlorovinyl)-L-cysteine
?
S-(p-bromophenyl)-L-cysteine
?
-
-
-
?
S-(p-bromophenyl)-L-cysteine
p-bromobenzenethiol + NH3 + pyruvate
-
-
-
?
S-1,2-dichlorovinyl-L-cysteine + H2O
dichlorovinyl mercaptane + NH3 + pyruvate
-
-
-
-
?
S-1,2-dichlorovinyl-L-cysteine + H2O
pyruvate + NH3 + dichlorovinyl mercaptane
-
-
-
-
?
S-4-(4-methylpentan-2-one)-L-cysteine + H2O
4-mercapto-4-methylpentan-2-one + NH3 + pyruvate
-
-
-
-
?
S-alkyl cysteines
?
-
-
-
-
?
S-allyl-L-cysteine + H2O
NH3 + pyruvate + prop-2-ene-1-thiol
-
-
-
-
ir
S-allylmercapto-L-cysteine + H2O
NH3 + pyruvate + allyl hydrodisulfide
-
-
-
-
ir
S-Aralkyl cysteines
?
-
-
-
-
?
S-benzyl-L-cysteine + H2O
?
S-carbamoyl-L-cysteine
?
-
-
-
?
S-ethyl-L-cysteine + H2O
?
-
18% of the activity with L-cystine
-
?
S-ethyl-L-cysteine sulfoxide + H2O
?
-
71% of the activity with L-cystine
-
?
S-methyl-L-Cys + H2O
?
-
-
-
-
?
S-methyl-L-cysteine
methyl mercaptane + pyruvate + NH3
S-methyl-L-cysteine + H2O
?
S-methyl-L-cysteine sulfoxide
methyl methanethiolsulfinate + pyruvate + NH3
S-methylcysteine + H2O
?
-
-
-
-
?
S-methylmercapto-L-cysteine + H2O
NH3 + pyruvate + methanethiol
-
-
-
-
ir
S-penta-1,3-dienylmercapto-L-cysteine + H2O
NH3 + pyruvate + penta-1,3-dien-1-yl hydrodisulfide
-
-
-
-
ir
S-propyl-L-cysteine
?
-
-
-
?
S-propyl-L-cysteine + H2O
?
-
29% of the activity with L-cystine
-
?
S-propylmercapto-L-cysteine + H2O
NH3 + pyruvate + propyl hydrodisulfide
-
-
-
-
ir
S-[1-(2-hydroxymethyl)-1-methylbutyl]-L-cysteine + H2O
sulfanylhexanol + ?
-
very low activity
-
-
?
S-[1-(2-hydroxymethyl)-1-methylbutyl]-L-cysteinylglycine + H2O
sulfanylhexanol + ?
-
very low activity
-
-
?
S-[2-(fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-L-cysteine
pyruvate + ?
-
-
-
?
S-[2-(fluoromethoxy)-1,3,3,3-tetrafluoropropyl]-L-cysteine
pyruvate + ?
-
-
-
?
Se-(4-methylbenzyl)-L-selenocysteine
?
-
-
-
?
Se-(allyl)-L-selenocysteine
?
-
-
-
?
Se-(hydroselenomethyl)selenocysteine
bis(hydroseleno)methane + pyruvate + NH3
-
-
-
ir
Se-(isopropyl)-L-selenocysteine
?
-
-
-
?
Se-(methyl)-L-selenocysteine
HSe(CH3) + pyruvate + NH3
-
-
-
-
?
Se-(phenyl)-L-selenocysteine
?
-
-
-
?
Se-4-methoxybenzylselenocysteine + H2O
HSe(4-(CH3O)C6H4CH2) + pyruvate + NH3
Se-methyl-L-selenocysteine
?
-
-
-
-
?
Se-methyl-L-selenocysteine + H2O
HSe(CH3) + pyruvate + NH3
-
-
-
?
Se-methylselenocysteine + H2O
HSe(CH3) + pyruvate + NH3
Te-phenyl-L-tellurocysteine + H2O
NH3 + pyruvate + phenyltelluride
-
-
-
-
ir
xenobiotics
thiol + pyruvate + NH3
-
-
-
?
additional information
?
-
(H2N)2Pt(Cl)SCH2CH(NH3+)CO2- + H2O

CH3C(O)CO2- + NH4+ + (NH2)2Pt(Cl)SH
-
-
-
-
?
(H2N)2Pt(Cl)SCH2CH(NH3+)CO2- + H2O
CH3C(O)CO2- + NH4+ + (NH2)2Pt(Cl)SH
-
-
-
-
?
(S)-2,4-dinitrophenyl-L-cysteine

2,4-dinitrobenzenethiol + pyruvate + NH3
-
-
-
-
?
(S)-2,4-dinitrophenyl-L-cysteine
2,4-dinitrobenzenethiol + pyruvate + NH3
-
-
-
?
(S)-2-benzothiazolyl-L-cysteine

pyruvate + NH3 + 2-mercaptobenzothiazole
-
-
-
-
?
(S)-2-benzothiazolyl-L-cysteine
pyruvate + NH3 + 2-mercaptobenzothiazole
-
-
-
?
(S)-4-bromophenyl-L-cysteine

p-bromobenzenethiol + NH3 + pyruvate
-
-
-
-
?
(S)-4-bromophenyl-L-cysteine
p-bromobenzenethiol + NH3 + pyruvate
-
-
-
?
(S)-4-bromophenyl-L-cysteine
p-bromobenzenethiol + NH3 + pyruvate
-
-
-
-
?
(S)-methylcysteine + H2O

methanethiol + pyruvate + NH3
-
-
-
-
?
(S)-methylcysteine + H2O
methanethiol + pyruvate + NH3
-
-
-
-
?
(S)-methylcysteine + H2O
methanethiol + pyruvate + NH3
-
-
-
-
?
(S)-methylcysteine + H2O
methanethiol + pyruvate + NH3
-
-
-
-
?
(S)-methylcysteine + H2O
methanethiol + pyruvate + NH3
-
-
-
-
?
(S)-methylcysteine + H2O
methanethiol + pyruvate + NH3
-
-
-
-
?
(S)-methylcysteine + H2O
methanethiol + pyruvate + NH3
-
-
-
-
?
2,4-dinitrophenyl-L-cysteine + H2O

2,4-dinitrobenzenethiol + pyruvate + NH3
-
-
-
-
?
2,4-dinitrophenyl-L-cysteine + H2O
2,4-dinitrobenzenethiol + pyruvate + NH3
-
-
-
-
?
2,4-dinitrophenyl-L-cysteine + H2O
2,4-dinitrobenzenethiol + pyruvate + NH3
-
-
-
-
?
2,4-dinitrophenyl-L-cysteine + H2O
2,4-dinitrobenzenethiol + pyruvate + NH3
-
-
-
-
?
2,4-dinitrophenyl-L-cysteine + H2O
2,4-dinitrobenzenethiol + pyruvate + NH3
-
-
-
-
?
3-cysteinylhexanol

3-mercaptohexanal + ?
-
-
S-configuration of product preferred
?
3-cysteinylhexanol
3-mercaptohexanal + ?
-
-
R-configuration of product preferred
?
3-S-(N-acetyl-L-cysteinyl)-hexanal

3-mercaptohexanal + ?
-
-
S-configuration of product preferred
?
3-S-(N-acetyl-L-cysteinyl)-hexanal
3-mercaptohexanal + ?
-
-
R-configuration of product preferred
?
3-S-L-cysteinylhexanal

3-mercaptohexanal + ?
-
-
-
?
3-S-L-cysteinylhexanal
3-mercaptohexanal + ?
-
-
-
?
benzothiazolyl-L-cysteine

?
-
-
-
-
?
benzothiazolyl-L-cysteine
?
-
-
-
-
?
cystathionine + H2O

?
-
enzyme is involved in methionine biosynthesis
-
-
?
cystathionine + H2O
?
-
the second enzyme unique to methionine biosynthesis
-
-
?
cystathionine + H2O
?
-
enzyme is involved in methionine biosynthesis
-
-
?
cystathionine + H2O
?
-
enzyme is involved in methionine biosynthesis
-
-
?
cystathionine + H2O
?
-
-
-
-
?
cystathionine + H2O

L-homocysteine + NH3 + pyruvate
-
-
-
-
?
cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
1-4% of the activity with L-cysteine, depending on assay method
-
?
cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
?
cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
-
?
cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
-
?
cystathionine + H2O

L-homocysteine + pyruvate + NH3
-
-
-
?
cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
DL-homocysteine + H2O

hydrogen sulfide + 2-oxobutyrate + ?
Ctl1 degrades DL-homocysteine at pH 5.5, while no activity is detected at pH 6.8 or 9.0
-
-
?
DL-homocysteine + H2O
hydrogen sulfide + 2-oxobutyrate + ?
Ctl2 degrades DL-homocysteine at pH 5.5, while no activity is detected at pH 6.8 or 9.0
-
-
?
L-alanine

?
-
transaminase activity
-
?
L-alanine
?
-
transaminase activity
-
?
L-aspartate

?
-
transaminase activity
-
?
L-aspartate
?
-
transaminase activity
-
?
L-cystathionine

L-homocysteine + pyruvate + NH4+
-
-
-
?
L-cystathionine
L-homocysteine + pyruvate + NH4+
-
-
-
-
?
L-cystathionine
L-homocysteine + pyruvate + NH4+
-
-
-
-
?
L-cystathionine + H2O

L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
recombinant Ctl1 shows high activity toward the degradation of L-cystathionine
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
recombinant Ctl2 shows high activity toward the degradation of L-cystathionine
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
alpha,beta-elimination
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
100% activity
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
100% activity
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
no gamma-cleavage
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
penultimate step in microbial and plant methionine biosynthesis
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
the enzyme catalyzes the split of the a C-N and of the beta C-S bonds through a beta-elimination
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
L-cystathionine + H2O

L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cysteine + H2O

?
-
-
-
-
?
L-cysteine + H2O
?
-
-
-
-
?
L-cysteine + H2O
?
-
12% of the activity with L-cystathionine
-
-
?
L-cysteine + H2O
?
1.0% activity compared to L-cystathionine
-
-
?
L-cysteine + H2O
?
1.0% activity compared to L-cystathionine
-
-
?
L-cysteine + H2O
?
-
7.5% of the activity with cystathionine
-
-
?
L-cysteine + H2O
?
-
7.5% of the activity with cystathionine
-
-
?
L-cysteine + H2O

hydrogen sulfide + pyruvate + ?
Ctl1 degrades L-cysteine at pH 5.5, while no activity is detected at pH 6.8 or 9.0
-
-
?
L-cysteine + H2O
hydrogen sulfide + pyruvate + ?
Ctl2 degrades L-cysteine at pH 5.5, while no activity is detected at pH 6.8 or 9.0
-
-
?
L-cysteine + H2O

pyruvate + NH3 + hydrogen sulfide
-
-
-
-
?
L-cysteine + H2O
pyruvate + NH3 + hydrogen sulfide
-
-
-
-
?
L-cysteine + H2O

sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
MalY
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
very low activity
-
-
?
L-cysteine conjugates

?
-
of aromatic compounds
-
-
?
L-cysteine conjugates
?
-
of aromatic compounds
-
-
?
L-cysteine conjugates
?
-
of aromatic compounds
-
-
?
L-cysteine conjugates
?
-
of aromatic compounds
-
-
?
L-cysteine conjugates
?
-
of aromatic compounds
-
-
?
L-cystine + H2O

L-thiocysteine + pyruvate + NH3
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
64% of the activity with L-cystathionine
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
28% of the activity with L-cystathionine
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
28% of the activity with L-cystathionine
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
87% of the activity with cystathionine
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
87% of the activity with cystathionine
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
17% of the activity with L-cystathionine
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
cystine is preferred over cysteine as substrate
-
-
?
L-djenkolate

pyruvate + NH3 + S-(mercaptomethyl)cysteine
-
-
-
-
?
L-djenkolate
pyruvate + NH3 + S-(mercaptomethyl)cysteine
-
-
-
-
?
L-djenkolate
pyruvate + NH3 + S-(mercaptomethyl)cysteine
-
-
-
?
L-djenkolate
pyruvate + NH3 + S-(mercaptomethyl)cysteine
-
-
-
-
ir
L-djenkolate + H2O

pyruvate
-
-
-
-
?
L-djenkolate + H2O
pyruvate
-
-
-
?
L-djenkolate + H2O
pyruvate
-
-
-
-
?
L-djenkolate + H2O
pyruvate
-
-
-
-
?
L-djenkolate + H2O
pyruvate
-
-
-
-
?
L-djenkolate + H2O
pyruvate
-
-
-
-
?
L-djenkolate + H2O
pyruvate
-
58% of the activity with L-cystathionine
-
-
?
L-djenkolate + H2O
pyruvate
-
79% of the activity with L-cystathionine
-
-
?
L-djenkolate + H2O
pyruvate
-
79% of the activity with L-cystathionine
-
-
?
L-djenkolate + H2O
pyruvate
-
-
-
?
L-djenkolate + H2O
pyruvate
-
-
-
-
?
L-djenkolate + H2O
pyruvate
-
-
-
?
L-djenkolate + H2O
pyruvate
-
-
-
-
?
L-djenkolate + H2O
pyruvate
-
126% of the activity with L-cystathionine
-
-
?
L-homocysteine + H2O

?
-
4% of the activity with L-cystathionine
-
-
?
L-homocysteine + H2O
?
-
5% of the activity with L-cystathionine
-
-
?
L-homocysteine + H2O
?
-
5% of the activity with L-cystathionine
-
-
?
L-methionine + H2O

methanethiol + dimethyl disulfide + dimethyl trisulfide + 2-oxobutyrate
Ctl1 degrades L-methionine at pH 5.5, while no activity is detected at pH 6.8 or 9.0
-
-
?
L-methionine + H2O
methanethiol + dimethyl disulfide + dimethyl trisulfide + 2-oxobutyrate
Ctl2 degrades L-methionine at pH 5.5, while no activity is detected at pH 6.8 or 9.0
-
-
?
L-methionine + H2O

methanethiol + NH3 + 2-oxobutanoate
-
-
-
?
L-methionine + H2O
methanethiol + NH3 + 2-oxobutanoate
-
-
-
-
?
L-selenocystathionine + H2O

?
-
-
-
-
?
L-selenocystathionine + H2O
?
-
-
-
-
?
L-selenocystathionine + H2O
?
-
-
-
-
?
L-Selenodjenkolate

Se-(hydroselenomethyl)selenocysteine + pyruvate + NH3
-
-
-
-
?
L-Selenodjenkolate
Se-(hydroselenomethyl)selenocysteine + pyruvate + NH3
-
-
-
-
?
L-Selenodjenkolate
Se-(hydroselenomethyl)selenocysteine + pyruvate + NH3
-
-
-
ir
lanthionine + H2O

L-cysteine + NH3 + pyruvate
-
-
-
-
?
lanthionine + H2O
L-cysteine + NH3 + pyruvate
-
169% of the activity with L-cystathionine
-
-
?
lanthionine + H2O
L-cysteine + NH3 + pyruvate
-
DL-lanthionine, 136% of the activity with L-cystathionine
-
-
?
lanthionine + H2O
L-cysteine + NH3 + pyruvate
-
DL-lanthionine, 136% of the activity with L-cystathionine
-
-
?
p-nitrobenzyl-L-cysteine

?
-
-
-
-
?
p-nitrobenzyl-L-cysteine
?
-
-
-
-
?
p-nitrobenzyl-L-cysteine
?
-
-
-
-
?
p-nitrobenzyl-L-cysteine
?
-
-
-
-
?
p-nitrobenzyl-L-cysteine
?
-
-
-
-
?
RS-CH2-CH(NH3+)COO- + H2O

RSH + NH3 + pyruvate
-
-
-
-
?
RS-CH2-CH(NH3+)COO- + H2O
RSH + NH3 + pyruvate
-
-
-
-
ir
RSH-CH2-CH(NH3+)COO-

RSH + NH3 + pyruvate
-
R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitorbenzene
-
?
RSH-CH2-CH(NH3+)COO-
RSH + NH3 + pyruvate
-
R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitorbenzene
-
?
RSH-CH2-CH(NH3+)COO-
RSH + NH3 + pyruvate
-
R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitorbenzene
-
?
RSH-CH2-CH(NH3+)COO-
RSH + NH3 + pyruvate
-
R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitorbenzene
-
?
RSH-CH2-CH(NH3+)COO-
RSH + NH3 + pyruvate
-
-
-
-
?
RSH-CH2-CH(NH3+)COO-
RSH + NH3 + pyruvate
-
R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitorbenzene
-
?
RSH-CH2-CH(NH3+)COO-
RSH + NH3 + pyruvate
-
R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitorbenzene
-
-
?
RSH-CH2-CH(NH3+)COO-
RSH + NH3 + pyruvate
-
R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitorbenzene
-
ir
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine

?
-
-
-
?
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
?
-
-
-
-
?
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
?
-
-
-
-
?
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
?
-
-
-
?
S-(1,2-dichlorovinyl)-L-cysteine

?
-
-
-
-
?
S-(1,2-dichlorovinyl)-L-cysteine
?
-
-
-
-
?
S-(1,2-dichlorovinyl)-L-cysteine + H2O

NH3 + pyruvate + 1,2-dichloroethylenethiol
-
-
-
-
?
S-(1,2-dichlorovinyl)-L-cysteine + H2O
NH3 + pyruvate + 1,2-dichloroethylenethiol
-
-
-
-
ir
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine

?
-
-
-
?
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
?
-
-
-
-
?
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
?
-
-
-
?
S-(E-1,2-Dichlorovinyl)-L-cysteine

?
-
-
-
?
S-(E-1,2-Dichlorovinyl)-L-cysteine
?
-
-
-
?
S-(E-1,2-Dichlorovinyl)-L-cysteine
?
Monieza expansa
-
-
-
?
S-(E-1,2-Dichlorovinyl)-L-cysteine
?
-
-
-
?
S-(E-1,2-Dichlorovinyl)-L-cysteine
?
-
-
-
?
S-benzyl-L-cysteine + H2O

?
-
-
-
-
?
S-benzyl-L-cysteine + H2O
?
-
-
-
-
?
S-ethyl-L-cysteine

?
9.0% activity compared to L-cystathionine
-
-
?
S-ethyl-L-cysteine
?
9.0% activity compared to L-cystathionine
-
-
?
S-methyl-L-cysteine

methyl mercaptane + pyruvate + NH3
-
-
-
-
?
S-methyl-L-cysteine
methyl mercaptane + pyruvate + NH3
-
-
-
-
?
S-methyl-L-cysteine
methyl mercaptane + pyruvate + NH3
-
-
-
-
ir
S-methyl-L-cysteine
methyl mercaptane + pyruvate + NH3
-
-
-
ir
S-methyl-L-cysteine
methyl mercaptane + pyruvate + NH3
-
-
-
-
?
S-methyl-L-cysteine + H2O

?
-
13-29% of the activity with L-cystine, depending on assay method
-
?
S-methyl-L-cysteine + H2O
?
7.4% activity compared to L-cystathionine
-
-
?
S-methyl-L-cysteine + H2O
?
7.4% activity compared to L-cystathionine
-
-
?
S-methyl-L-cysteine sulfoxide

methyl methanethiolsulfinate + pyruvate + NH3
-
-
-
-
?
S-methyl-L-cysteine sulfoxide
methyl methanethiolsulfinate + pyruvate + NH3
-
-
-
?
Se-4-methoxybenzylselenocysteine + H2O

HSe(4-(CH3O)C6H4CH2) + pyruvate + NH3
-
-
-
-
?
Se-4-methoxybenzylselenocysteine + H2O
HSe(4-(CH3O)C6H4CH2) + pyruvate + NH3
-
-
-
-
?
Se-4-methoxybenzylselenocysteine + H2O
HSe(4-(CH3O)C6H4CH2) + pyruvate + NH3
-
-
-
-
?
Se-4-methoxybenzylselenocysteine + H2O
HSe(4-(CH3O)C6H4CH2) + pyruvate + NH3
-
-
-
-
?
Se-4-methoxybenzylselenocysteine + H2O
HSe(4-(CH3O)C6H4CH2) + pyruvate + NH3
-
-
-
-
?
Se-4-methoxybenzylselenocysteine + H2O
HSe(4-(CH3O)C6H4CH2) + pyruvate + NH3
-
-
-
-
?
Se-4-methoxybenzylselenocysteine + H2O
HSe(4-(CH3O)C6H4CH2) + pyruvate + NH3
-
-
-
-
?
Se-methylselenocysteine + H2O

HSe(CH3) + pyruvate + NH3
-
-
-
-
?
Se-methylselenocysteine + H2O
HSe(CH3) + pyruvate + NH3
-
-
-
-
?
Se-methylselenocysteine + H2O
HSe(CH3) + pyruvate + NH3
-
-
-
-
?
Se-methylselenocysteine + H2O
HSe(CH3) + pyruvate + NH3
-
-
-
-
?
Se-methylselenocysteine + H2O
HSe(CH3) + pyruvate + NH3
-
-
-
-
?
Se-methylselenocysteine + H2O
HSe(CH3) + pyruvate + NH3
-
-
-
-
?
Se-methylselenocysteine + H2O
HSe(CH3) + pyruvate + NH3
-
-
-
-
?
thioethers

?
-
of L-cysteine, in which the amino acid's amino and carboxyl groups remain free
-
-
?
thioethers
?
-
of L-cysteine, in which the amino acid's amino and carboxyl groups remain free
-
-
?
thioethers
?
-
of L-cysteine, in which the amino acid's amino and carboxyl groups remain free
-
-
?
thioethers
?
-
of L-cysteine, in which the amino acid's amino and carboxyl groups remain free
-
-
?
thioethers
?
-
of L-cysteine, in which the amino acid's amino and carboxyl groups remain free
-
-
?
additional information

?
-
the enzyme catalyzes the penultimate step in de novo biosynthesis of Met in microbes and plants
-
?
additional information
?
-
-
two types of cystathionine beta-cleavage enzyme
-
-
?
additional information
?
-
-
osteotoxin is lethal for MC3T3-E1 osteogenic cells, fetal bovine trabecular cells, UMR106-01(BSP) rat osteosarcoma cells and embryonic bovine tracheal cells. The cytotoxicity can be attributed to: 1. beta-cystathionase-catalyzed cleavage of L-cystine in the medium and formation of reactive sulfane-containing derivatives, 2. Transfer of sulfane sulfur to metabolically sensitive or structurally important proteins in the osteogenic cells
-
-
?
additional information
?
-
-
the enzyme is responsible for off-aroma deterioration in fresh unblanched broccoli
-
?
additional information
?
-
the Pelagibacter ubique cystathionine beta-lyase (CBL) also shows a promiscuous alanine racemase (ALR) activity (cf. EC 5.1.1.1). ALR catalyzes the interconversion of L-alanine and D-alanine. The ALR activity of MBP-PuCBL is 40fold lower than its CBL activity
-
-
-
additional information
?
-
the Pelagibacter ubique cystathionine beta-lyase (CBL) also shows a promiscuous alanine racemase (ALR) activity (cf. EC 5.1.1.1). ALR catalyzes the interconversion of L-alanine and D-alanine. The ALR activity of MBP-PuCBL is 40fold lower than its CBL activity
-
-
-
additional information
?
-
-
L-cysteine, S-methyl-L-cysteine
-
-
?
additional information
?
-
-
cystathionine
-
-
?
additional information
?
-
-
not: D-cysteine derivatives, DL-homocysteine derivatives
-
-
?
additional information
?
-
-
stereochemical ananlyses of product
-
?
additional information
?
-
the Escherichia coli cystathionine beta-lyase (CBL) also shows a promiscuous alanine racemase (ALR) activity (cf. EC 5.1.1.1). ALR catalyzes the interconversion of L-alanine and D-alanine
-
-
-
additional information
?
-
-
stereochemical ananlyses of product
-
?
additional information
?
-
-
intestinal microflora: formation of methylthio-containing metabolites
-
-
?
additional information
?
-
-
enzyme shows transaminase activity against L-aspartate and L-alanine
-
?
additional information
?
-
-
detoxification
-
-
?
additional information
?
-
-
detoxification
-
-
?
additional information
?
-
-
cisplatin is bioactivated by the enzyme, renal toxicity of cisplatin results from enzyme activity, in contrast, carboplatin is not bioactivated
-
?
additional information
?
-
-
beta-lyase reactions with S-(1,1,2,2-tetrafluoroethyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-cysteine, and Se-methyl-L-selenocysteine are more favorable than the GTK-catalyzed aminotransferase reactions with these amino acids
-
-
?
additional information
?
-
-
no reaction with 5-S-L-cysteinyl-L-DOPA
-
-
?
additional information
?
-
human KAT III/CCBL2, EC 2.6.1.7, possesses cysteine S-conjugate beta-lyase activity. KAtT III and glutamine transaminase L are identical enzymes
-
-
?
additional information
?
-
-
human KAT III/CCBL2, EC 2.6.1.7, possesses cysteine S-conjugate beta-lyase activity. KAtT III and glutamine transaminase L are identical enzymes
-
-
?
additional information
?
-
-
the enzyme is implicated in the degradation of not only cystathionine but also cysteine and methionine
-
-
?
additional information
?
-
the enzyme is implicated in the degradation of not only cystathionine but also cysteine and methionine
-
-
?
additional information
?
-
-
the enzyme performs a beta-elimination reaction, substrate specificity and product determination, overview
-
-
?
additional information
?
-
the enzyme performs a beta-elimination reaction, substrate specificity and product determination, overview
-
-
?
additional information
?
-
enzyme also is able to catalyze an alpha,gamma-elimination
-
?
additional information
?
-
-
enzyme also is able to catalyze an alpha,gamma-elimination
-
?
additional information
?
-
with methionine as substrate the enzyme produces volatile sulfur compounds which are important for flavor formation in Gouda cheese
-
?
additional information
?
-
-
with methionine as substrate the enzyme produces volatile sulfur compounds which are important for flavor formation in Gouda cheese
-
?
additional information
?
-
-
L-cysteine, S-methyl-L-cysteine
-
-
?
additional information
?
-
-
cystathionine
-
-
?
additional information
?
-
-
not: D-cysteine derivatives, DL-homocysteine derivatives
-
-
?
additional information
?
-
substrate docking study. The largest attractive force that stabilizes the amino group of the ethyl chain moiety is contributed by Arg433. The negative charge of the carboxyl group in the ethyl chain is balanced by a hydrogen bond between it and amino group of Lys271. The propyl chain moiety of cystathionine is stabilized by the guanidium groups of two residues, Arg179 and Arg122'. Phosphate group of PLP forms two hydrogen bonds between hydroxy hydrogen of Ser268 and guanidium hydrogen of Arg122'
-
-
?
additional information
?
-
-
substrate docking study. The largest attractive force that stabilizes the amino group of the ethyl chain moiety is contributed by Arg433. The negative charge of the carboxyl group in the ethyl chain is balanced by a hydrogen bond between it and amino group of Lys271. The propyl chain moiety of cystathionine is stabilized by the guanidium groups of two residues, Arg179 and Arg122'. Phosphate group of PLP forms two hydrogen bonds between hydroxy hydrogen of Ser268 and guanidium hydrogen of Arg122'
-
-
?
additional information
?
-
-
L-cysteine, S-methyl-L-cysteine
-
-
?
additional information
?
-
-
cystathionine
-
-
?
additional information
?
-
-
not: D-cysteine derivatives, DL-homocysteine derivatives
-
-
?
additional information
?
-
-
L-cysteine, S-methyl-L-cysteine
-
-
?
additional information
?
-
-
cystathionine
-
-
?
additional information
?
-
-
not: D-cysteine derivatives, DL-homocysteine derivatives
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
L-cysteine, S-methyl-L-cysteine
-
-
?
additional information
?
-
-
cystathionine
-
-
?
additional information
?
-
-
cystathionine
-
-
?
additional information
?
-
-
the 4-nitrophenylethyl, benzyl, methyl, 2-chloroethyl, butyl thioethers of cysteine
-
-
?
additional information
?
-
-
not: D-cysteine derivatives, DL-homocysteine derivatives
-
-
?
additional information
?
-
-
kinetic analyses and comparison of beta-elimination reaction and transamination reaction for differentially substituted cysteine-S-conjugates and selenocysteine Se-conjugates
-
?
additional information
?
-
-
no reaction with S-benzothiazolyl-L-cysteine
-
-
?
additional information
?
-
-
cysteine S-conjugate beta-lyases catalyze beta-elimination reactions with cysteine S-conjugates that possess a good leaving group in the beta-position. The end products are aminoacrylate and a sulfur-containing fragment. The aminoacrylate tautomerizes and hydrolyzes to pyruvate and ammonia.
-
-
?
additional information
?
-
Irc7p, a putative cystathionine beta-lyase, is one of the main proteins catalyzing the 4-methyl-4-sulfanylpentan-2-one and 3-sulfanylhexan-1-ol, as aromatic compounds, release from inodorous nonvolatile cysteinylated precursors under enological conditions. The two other beta-lyases Ure2p and Gln3p mainly control the bioconversion of volatile thiols by the transcriptional regulation of the IRC7 gene through the general mechanism of nitrogen catabolic repression
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additional information
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Irc7p, a putative cystathionine beta-lyase, is one of the main proteins catalyzing the 4-methyl-4-sulfanylpentan-2-one and 3-sulfanylhexan-1-ol, as aromatic compounds, release from inodorous nonvolatile cysteinylated precursors under enological conditions. The two other beta-lyases Ure2p and Gln3p mainly control the bioconversion of volatile thiols by the transcriptional regulation of the IRC7 gene through the general mechanism of nitrogen catabolic repression
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additional information
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Irc7p is a specifically stereoselective enzyme
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-
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additional information
?
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Irc7p is a specifically stereoselective enzyme
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additional information
?
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no alpha-ketobutyrate is detected with any of the substrates susceptible for beta-lyase activity, confirming that Str3p has only beta-lyase activity. L-methionine is no substrate for Str3p
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additional information
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no alpha-ketobutyrate is detected with any of the substrates susceptible for beta-lyase activity, confirming that Str3p has only beta-lyase activity. L-methionine is no substrate for Str3p
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additional information
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no alpha-ketobutyrate is detected with any of the substrates susceptible for beta-lyase activity, confirming that Str3p has only beta-lyase activity. L-methionine is no substrate for Str3p
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additional information
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the enzyme catalyzes the penultimate step in methionine biosynthesis. The enzyme is important for bacterial virulence
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additional information
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the enzyme plays a central role in methionine biosynthesis
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additional information
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the enzyme plays a central role in methionine biosynthesis
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additional information
?
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no activity with cysteine, cysteinyl, or cysteinylglycine-S-precursors (S-[1-(2-hydroxymethyl)-1-methylbutyl]-lcysteinylglycine and S-[1-(2-hydroxymethyl)-1-methylbutyl]-l-cysteine)
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additional information
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the enzyme is involved in generation of sulfur-containing amino acids in streptomycete
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additional information
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the enzyme is involved in generation of sulfur-containing amino acids in streptomycete
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additional information
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the catalytic mechanism is proposed involving interactions between cystine and active site residues Arg360, Arg369, and Trp251. These residues reorient during beta-elimination reaction, leading to the formation of a hydrophobic pocket that stabilizes the enolimine tautomer of the aminoacrylate and the cysteine persulfide product
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additional information
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enzyme displays both cystine C-S lyase activity and alanine aminotransferase activity, Ec 2.6.1.2. No in vitro tyrosine aminotransferase activity is detetced
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additional information
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the enzyme is a physiologically bifunctional alanine/glutamate racemase (EC 5.1.1.1/EC 5.1.1.3), it is not highly active, but it is clearly sufficient. The metC encoded L-alanine/L-glutamate racemase is a multifunctional CBL/ALR. CBL activity is no longer required in these bacteria
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additional information
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no activity with O-acetylhomoserine or O-succinylhomoserine plus L-cysteine, the cystathionine gamma-synthase (metB, EC 2.5.1.48) activity of the enzyme is negligible
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additional information
?
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the enzyme is a physiologically bifunctional alanine/glutamate racemase (EC 5.1.1.1/EC 5.1.1.3), it is not highly active, but it is clearly sufficient. The metC encoded L-alanine/L-glutamate racemase is a multifunctional CBL/ALR. CBL activity is no longer required in these bacteria
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additional information
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the GLR (EC 5.1.1.3) activity of wMelCBL is very weak: approximately 3fold less efficient than cystathionine beta-elimination (EC 4.4.1.13) and 28fold less efficient than alanine racemization (EC 5.1.1.1)
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additional information
?
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the enzyme is a physiologically bifunctional alanine/glutamate racemase (EC 5.1.1.1/EC 5.1.1.3), it is not highly active, but it is clearly sufficient. The metC encoded L-alanine/L-glutamate racemase is a multifunctional CBL/ALR. CBL activity is no longer required in these bacteria
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0.5
2,4-dinitrophenyl-L-cysteine
0.013
3-hydroxy-kynurenine
-
-
0.6
beta-chloro-L-alanine
-
-
2.6
beta-chloroalanine
-
-
1
cystine
-
estimated from steady-state measurements
0.04 - 15
L-cystathionine
4.5
L-homolanthionine
-
-
0.83
L-meso-lanthionine
-
-
0.35
L-selenocystathionine
-
-
6.5
O-methyl-DL-serine
-
-
0.008
pyridoxal phosphate
-
-
8.4
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
23°C, pH 7.4
1.36 - 1.39
S-(1,2-dichlorovinyl)-L-cysteine
0.47
S-(2-aminoethyl)-L-Cys
-
-
0.01 - 1.66
S-(2-benzothiazolyl)-L-cysteine
1.02 - 1.78
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
0.7
S-(p-bromophenyl)-L-cysteine
-
-
0.1 - 0.33
S-1,2-dichlorovinyl-L-cysteine
0.08
S-2,4-dinitrophenyl-L-cysteine
-
-
0.73
S-Benzyl-L-cysteine
-
-
2.3 - 5.3
S-methyl-L-cysteine
2.3
S-methyl-L-cysteine sulfoxide
-
-
4.6
Se-(methyl)-L-selenocysteine
-
-
additional information
additional information
-
0.5
2,4-dinitrophenyl-L-cysteine

-
-
0.5
2,4-dinitrophenyl-L-cysteine
-
-
0.5
2,4-dinitrophenyl-L-cysteine
-
-
0.5
2,4-dinitrophenyl-L-cysteine
-
-
0.5
2,4-dinitrophenyl-L-cysteine
-
-
0.02
cystathionine

recombinant His-tagged enzyme, pH 8.0, 37°C
0.4
cystathionine
recombinant His-tagged enzyme, pH 8.0, 37°C, Tris buffer
0.7
cystathionine
recombinant His-tagged enzyme, pH 8.0, 37°C, bicine buffer
1.3
cystathionine
recombinant His-tagged enzyme, pH 8.0, 70°C, bicine buffer
1.62
cystathionine
-
pH 9.0, 30°C
2.1
cystathionine
recombinant MBP-tagged enzyme, pH 8.0, 37°C
2.4
cystathionine
pH 8.5, 37°C, recombinant enzyme
1
DL-homocysteine

Ctl2, at pH 5.5 and 37°C
1.4
DL-homocysteine
Ctl1, at pH 5.5 and 37°C
0.04
L-cystathionine

-
-
0.068
L-cystathionine
pH 8.5, 25°C, recombinant mutant S32A
0.096
L-cystathionine
in 50 mM phosphate buffer, pH 8.5, 0.02 mM pyridoxal 5'-phosphate, 1 mM EDTA, at 37°C
0.101
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F
0.104
L-cystathionine
pH 8.5, 25°C, recombinant mutant S33A
0.108
L-cystathionine
pH 8.5, 25°C, recombinant wild-type enzyme
0.116
L-cystathionine
pH 8.5, 25°C, recombinant wild-type enzyme
0.121
L-cystathionine
pH 8.5, 25°C, recombinant mutant W188F
0.131
L-cystathionine
pH 8.5, 25°C, recombinant mutant W276F
0.148
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F/W188F/W230F/W276F/W300F
0.15
L-cystathionine
-
chloroplastic isoenzyme
0.161
L-cystathionine
pH 8.5, 25°C, recombinant mutant W300F
0.171
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131FF/W230FF/W276F
0.18
L-cystathionine
-
wild type enzyme, at 25°C
0.19
L-cystathionine
pH 8.5, 25°C, recombinant mutant W230F
0.22
L-cystathionine
pH 8.5, 25°C, recombinant mutant K42A
0.27
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F/W188F/W230F/W276F
0.31
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F/W230F/W276F/W300F
0.33
L-cystathionine
Ctl2, in sodium phosphate buffer, at pH 5.5 and 37°C
0.35
L-cystathionine
Ctl1, in sodium phosphate buffer, at pH 5.5 and 37°C
0.37
L-cystathionine
Ctl1, in sodium phosphate buffer, at pH 6.8 and 37°C
0.41
L-cystathionine
Ctl2, in sodium phosphate buffer, at pH 6.8 and 37°C
0.55
L-cystathionine
-
mutant enzyme D116N, at 25°C
0.67
L-cystathionine
-
mutant enzyme D116A, at 25°C
0.91
L-cystathionine
pH 8.5, 25°C, recombinant mutant W340F
1
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F/W230F/W276F/W340F
1.02
L-cystathionine
-
mutant enzyme R59A, at 25°C
1.05
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F/W188F/W276F/W300F/W340F
1.2
L-cystathionine
-
pH 8.0, 37°C, purified recombinant enzyme
1.26
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F/W230F/W276F/W300F/W340F
1.3
L-cystathionine
-
pH 8.5, 37°C, purified recombinant enzyme
1.35
L-cystathionine
-
mutant enzyme W340F, at 25°C
1.51
L-cystathionine
-
mutant enzyme R59K, at 25°C
1.8
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F/W188F/W230F/W276F/W300F/W340F
1.8
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F/W188F/W230F/W276F/W340F
2
L-cystathionine
pH 8.5, 25°C, recombinant mutant W188F/W230F/W276F/W300F/W340F
2.1
L-cystathionine
pH 8.5, 25°C, recombinant mutant W131F/W188F/W230F/W300F/W340F
3.8
L-cystathionine
pH 8.5, 25°C, recombinant chimeric mutant enzyme eCGS-sC-eCBL
5.1
L-cystathionine
-
mutant enzyme R58A, at 25°C
15
L-cystathionine
-
mutant enzyme R372K, at 25°C
0.29
L-cysteine

-
in presence of 10 mM dithiothreitol
0.3
L-cysteine
Ctl2, at pH 5.5 and 37°C
1
L-cysteine
Ctl1, at pH 5.5 and 37°C
0.0812
L-cystine

-
-
0.033
L-djenkolate

-
-
0.178
L-djenkolate
in 50 mM phosphate buffer, pH 8.5, 0.02 mM pyridoxal 5'-phosphate, 1 mM EDTA, at 37°C
0.34
L-djenkolate
-
chloroplastic isoenzyme
32.8
L-methionine

Ctl1, at pH 5.5 and 37°C
34.2
L-methionine
Ctl2, at pH 5.5 and 37°C
1.36
S-(1,2-dichlorovinyl)-L-cysteine

-
cytoplasm
1.39
S-(1,2-dichlorovinyl)-L-cysteine
-
mitochondria
0.01
S-(2-benzothiazolyl)-L-cysteine

-
-
0.29
S-(2-benzothiazolyl)-L-cysteine
-
-
0.66
S-(2-benzothiazolyl)-L-cysteine
-
mitochondria
1.66
S-(2-benzothiazolyl)-L-cysteine
-
cytoplasm
1.02
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine

-
mitochondria
1.78
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
cytoplasm
0.1
S-1,2-dichlorovinyl-L-cysteine

-
-
0.33
S-1,2-dichlorovinyl-L-cysteine
-
-
2.3
S-methyl-L-cysteine

-
-
5.1
S-methyl-L-cysteine
-
-
5.3
S-methyl-L-cysteine
-
-
additional information
additional information

-
-
-
additional information
additional information
-
-
-
additional information
additional information
steady-state kinetics
-
additional information
additional information
-
kinetic parameters for differentially substituted cysteine-S-conjugates and selenocysteine Se-conjugates
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
-
kinetics, overview
-
additional information
additional information
Michaelis-Menten steady-state kinetics
-
additional information
additional information
Michaelis-Menten steady-state kinetics
-
additional information
additional information
Michaelis-Menten steady-state kinetics
-
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