Information on EC 4.2.3.98 - (+)-T-muurolol synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.98 (+)-T-muurolol synthase
IUBMB Comments
The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original 1-pro-S hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T-muurolol.
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The enzyme appears in viruses and cellular organisms
Synonyms
SCLAV_p0068, SSCG_03688, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate
show the reaction diagram
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