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Information on EC 4.2.3.98 - (+)-T-muurolol synthase
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The expected taxonomic range for this enzyme is: Streptomyces clavuligerus
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EC NUMBER 
COMMENTARY 
4.2.3.98
-
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RECOMMENDED NAME
GeneOntology No.
(+)-T-muurolol synthase
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate
cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original H-1si of FPP, cyclization and deprotonation result in product (+)-T-muurolol
(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate
cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original H-1si of FPP, cyclization and deprotonation result in product (+)-T-muurolol
-
-
(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-T-muurolol-forming)
The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original 1-pro-S hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T-muurolol.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + H2O
(+)-T-muurolol + diphosphate
-
(+)-T-muurolol i.e. (1R,4R,4aS,8aR)-1,6-dimethyl-4-(propan-2-yl)-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol
-
?
(2E,6E)-farnesyl diphosphate + H2O
(+)-T-muurolol + diphosphate
cyclization mechanism a 1,3-hydride shift of the original H-1si of FPP
more than 95% of product
-
?
(2E,6E)-farnesyl diphosphate + H2O
(+)-T-muurolol + diphosphate
-
(+)-T-muurolol i.e. (1R,4R,4aS,8aR)-1,6-dimethyl-4-(propan-2-yl)-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol
-
?
(2E,6E)-farnesyl diphosphate + H2O
(+)-T-muurolol + diphosphate
cyclization mechanism a 1,3-hydride shift of the original H-1si of FPP
more than 95% of product
-
?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0027
(2E,6E)-farnesyl diphosphate
30°C, pH not specified in the publication; 30°C, pH not specified in the publication, presence of Mg2+
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00163
(2E,6E)-farnesyl diphosphate
30°C, pH not specified in the publication; 30°C, pH not specified in the publication, presence of Mg2+
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 4.2.3.98)
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