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Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained.
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The enzyme appears in viruses and cellular organisms
avermitilol synthase, more
(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate
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