Information on EC - aristolochene synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
       aristolochene synthase
IUBMB Comments
The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene. While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC, germacrene-A synthase). The enzyme from Penicillium roqueforti requires Mg2+. Mn2+ can partially substitute, at low concentrations. Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
5-epi-aristolochene synthase, Ari1, aristolochene synthase, AS, ATAS, cyclase, farnesyl pyrophosphate, EAS, EC, EC, farnesylpyrophosphate cyclase, more
(2E,6E)-farnesyl diphosphate = aristolochene + diphosphate
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further cyclization and methyl transfer converts the intermediate into aristolochene
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