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Information on EC 4.2.3.23 - germacrene-A synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.23 germacrene-A synthase
IUBMB Comments
Requires Mg2+ for activity. While germacrene A is an enzyme-bound intermediate in the biosynthesis of a number of phytoalexins, e.g. EC 4.2.3.9 (aristolochene synthase) from some species and EC 4.2.3.21 (vetispiradiene synthase), it is the sole sesquiterpenoid product formed in chicory .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
germacrene a synthase, (+)-germacrene a synthase, (+)-(10r)-germacrene a synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate = (+)-(R)-gemacrene A + diphosphate
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