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Information on EC 4.2.3.108 - 1,8-cineole synthase

for references in articles please use BRENDA:EC4.2.3.108

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IUBMB Comments

Requires Mn2+ or Zn2+. Mg2+ is less effective than either. 1,8-Cineole is the main product from the enzyme with just traces of other monoterpenoids. The oxygen atom is derived from water. The reaction proceeds via linalyl diphosphate and α-terpineol, the stereochemistry of both depends on the organism. However neither intermediate can substitute for geranyl diphosphate. The reaction in Salvia officinalis (sage) proceeds via (–)-(3R)-linalyl diphosphate [1-3] while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate .

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
1,8-cineole synthase, aatps6, 1,8-cineole cyclase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranyl diphosphate + H2O = 1,8-cineole + diphosphate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
monoterpene biosynthesis
Highest Expressing Human Cell Lines
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